Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jarrod A. Dudakov"'
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. deRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109789- (2021)
Summary: The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity for repair. However, the mechanisms orchestrating regeneration are poorly understood, and delayed repair is c
Externí odkaz:
https://doaj.org/article/65afcaf448bd428a8b80a25ba8962d2a
Autor:
Sinéad Kinsella, Jarrod A. Dudakov
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or common cancer therapies such as cytoreductive chemo- or radiation-therapy, it also has a remarkable capacity for repair. This phenomenon of endogenous thymic r
Externí odkaz:
https://doaj.org/article/9f2c2a07ac0f4d26ac8127edf618e641
Autor:
Danika M. Khong, Jarrod A. Dudakov, Maree V. Hammett, Marc I. Jurblum, Sacha M.L. Khong, Gabrielle L. Goldberg, Tomoo Ueno, Lisa Spyroglou, Lauren F. Young, Marcel R.M. van den Brink, Richard L. Boyd, Ann P. Chidgey
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 445-458 (2015)
Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation
Externí odkaz:
https://doaj.org/article/f2416eba1db045e3924adadc678b2527
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, Enrico Velardi, Jarrod A. Dudakov
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18efc9a131627f508f25e89f68542965
https://doi.org/10.1101/2023.01.19.524800
https://doi.org/10.1101/2023.01.19.524800
Autor:
Lorenzo Iovino, Kirsten Cooper, Paul DeRoos, Cindy Evandy, David Granadier, Sinéad Kinsella, Dante Denny Acenas, Jarrod A Dudakov
Publikováno v:
Blood. 140:10206-10207
Autor:
David Granadier, Kirsten Cooper, Sinéad Kinsella, Cindy Evandy, Lorenzo Iovino, Paul DeRoos, Steve Shannon-Sevillano, Dante Denny Acenas, Jarrod A Dudakov
Publikováno v:
Blood. 140:1169-1170
Autor:
Marcel R.M. van den Brink, Christopher P. Coplen, Jennifer L. Uhrlaub, Bonnie LaFleur, Sandip Ashok Sonar, Janko Nikolich-Zugich, Mladen Jergović, Gregory D. Sempowski, Jarrod A Dudakov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(17)
Secondary lymphoid organs (SLO; including the spleen and lymph nodes) are critical both for the maintenance of naïve T (TN) lymphocytes and for the initiation and coordination of immune responses. How they age, including the exact timing, extent, ph
Autor:
Lorenzo Iovino, Kirsten Cooper, Paul deRoos, Sinéad Kinsella, Cindy Evandy, Tamas Ugrai, Francesco Mazziotta, Kathleen S. Ensbey, David Granadier, Kayla Hopwo, Colton Smith, Alex Gagnon, Sara Galimberti, Mario Petrini, Geoffrey R. Hill, Jarrod A. Dudakov
Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HCT), contributing to the risk of infections and malignant relapse. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648072dd1735d66531c230f523429cd
http://hdl.handle.net/11568/1145218
http://hdl.handle.net/11568/1145218
Autor:
Anastasia I. Kousa, Lorenz Jahn, Kelin Zhao, Angel E. Flores, David Granadier, Kirsten Cooper, Julie M. Sheridan, Andri Lemarquis, Lisa Sikkema, Kimon V. Argyropoulos, Jennifer Tsai, Amina Lazrak, Katherine Nichols, Nichole Lee, Romina Ghale, Florent Malard, Hana Andrlova, Antonio L.C. Gomes, Enrico Velardi, Salma Youssef, Marina B. da Silva, Melissa Docampo, Roshan Sharma, Linas Mazutis, Verena C. Wimmer, Kelly L. Rogers, Susan DeWolf, Brianna Gipson, Manu Setty, Dana Pe’er, Nancy R. Manley, Daniel H.D. Gray, Jarrod A. Dudakov, Marcel R.M. van den Brink
SUMMARYThe thymus is essential for establishing adaptive immunity yet undergoes age-related atrophy leading to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a98885855bfe93656ffd3ed4004f71
https://doi.org/10.1101/2021.12.16.472014
https://doi.org/10.1101/2021.12.16.472014
Autor:
Alexander C. Gagnon, Mario Petrini, Paul DeRoos, Kayla S. Hopwo, Tamas Ugrai, David W. Granadier, Lorenzo Iovino, Sinéad Kinsella, Kirsten Cooper, Geoffrey R. Hill, Colton W. Smith, Kathleen S. Ensbey, Jarrod A Dudakov, Sara Galimberti, Francesco Mazziotta, Cindy A. Evandy
Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HCT), contributing toward the risk of infections and malignant relapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b762ec3e9db8f33239d91324977c1c
https://doi.org/10.1101/2021.09.02.458741
https://doi.org/10.1101/2021.09.02.458741