Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jarret Engstrom"'
Autor:
Sharon L. Achilles, Peter A. Anton, Nicola Richardson-Harman, Ross D Cranston, Jarret Engstrom, Kaleab Z. Abebe, Sylvain Chawki, Hans M. L. Spiegel, Beatrice A. Chen, Craig W. Hendrix, Cindy Jacobson, Aaron Siegel, Mark A. Marzinke, Lisa C. Rohan, Alex Reinhart, John Steytler, Ron Stall, Elena Khanukova, Ian McGowan, Rhonda M. Brand
Publikováno v:
AIDS Res Hum Retroviruses
The Combination HIV Antiretroviral Rectal Microbicide-3 (CHARM-03) study was a randomized, open-label, crossover Phase 1 safety and pharmacokinetic (PK) study of oral maraviroc (MVC) and MVC 1% gel. At a single site, healthy HIV-uninfected men and wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e017b88cd60d3a0ac5b2b8db7cf5512
https://pubmed.ncbi.nlm.nih.gov/34384282
https://pubmed.ncbi.nlm.nih.gov/34384282
Autor:
Shikhar Uttam, E. Jeffrey Metter, Rhonda M. Brand, Aaron Siegel, David G. Binion, Jarret Engstrom, Ian McGowan, Marc Schwartz, Randall E. Brand, Ashley Zyhowski, David C. Whitcomb, Nabanita Biswas, Beverley A. Moore
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Poor translatability of animal disease models has hampered the development of new inflammatory bowel disorder (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly obtained and well-characterized human colorectal tissue from pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc69766bfbaebe6e099aed2d028f0c3a
https://doi.org/10.1152/ajpgi.00383.2020
https://doi.org/10.1152/ajpgi.00383.2020
Publikováno v:
AIDS Research and Human Retroviruses. 35:326-334
Ex vivo explant models are used to characterize in vitro efficacy of preexposure prophylaxis (PrEP) agents. Tissue is challenged with virus in culture and HIV-1 p24 levels are quantified with enzyme-linked immunosorbent assay (ELISA) on supernatants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b1d27575033b3405b22cdf84d739ee
https://doi.org/10.1089/aid.2018.0227
https://doi.org/10.1089/aid.2018.0227
Autor:
Ashley Myerski, Ian McGowan, Rhonda M. Brand, Aaron Siegel, E. Jeffrey Metter, Nabanita Biswas, Ross D. Cranston, Jarret Engstrom, Randall E. Brand
Publikováno v:
Journal of Immunological Methods. 463:39-46
Background There are limited data on the immunological responsiveness of healthy intestinal tissue when it is cultured and stimulated ex vivo. Such an ex vivo model has the potential to be a valuable tool in understanding disease pathogenesis and as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cd5fa6f796ca39a2fbe68baac6b2b5
https://doi.org/10.1016/j.jim.2018.08.009
https://doi.org/10.1016/j.jim.2018.08.009
Autor:
Ian McGowan, Monika Tomaszewska-Kiecana, Beata Kosak, Jarret Engstrom, Bozena Korczak, Oliver Hartley, Niko Tzakis
Publikováno v:
AIDS research and human retroviruses. 37(6)
OB-002 is an extremely potent CCR5 antagonist that has previously been shown to completely block transmission in a nonhuman primate model of HIV infection. The purpose of this study was to characterize the safety, acceptability, and pharmacokinetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ddf74e3e16af42feda0f28d30909f1
https://pubmed.ncbi.nlm.nih.gov/33749321
https://pubmed.ncbi.nlm.nih.gov/33749321
Autor:
Randall E. Brand, Jamie Sulley, Ashley Myerski, E. Metter, Thomas W. Hodge, Jarret Engstrom, Aaron Siegel, Ian McGowan, Rhonda M. Brand, Luis Squiquera, Ross D. Cranston
Publikováno v:
AIDS Research and Human Retroviruses. 34:838-848
Ranpirnase (RNP) is a low molecular weight type III endoribonuclease, which demonstrates broad antiviral and antitumor properties. We sought to characterize the antiviral activity of RNP against HIV-1 and to determine whether RNP modulates local infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdd1a6977f92f1fe2d23316829e8185
https://doi.org/10.1089/aid.2017.0308
https://doi.org/10.1089/aid.2017.0308
Autor:
Alexiy Nikiforov, Nicola Richardson-Harman, Peter Williams, Jarret Engstrom, Rhonda M. Brand, Cory Shetler, Charlene S. Dezzutti, Ron Stall, Ian McGowan, Khaleel K Rehman, Saye Khoo, Ross D. Cranston, Beatrice A. Chen, Kathryn Duffill, Aaron Siegel, Amy Adler, Kaleab Z. Abebe, Sharon L. Achilles, Laura Else, David Back, James E. Egan, Deidre Egan
Publikováno v:
LANCET HIV
Long-acting injectable antiretroviral agents are being developed for HIV-1 prevention. The MWRI-01 study was done to characterise the safety, acceptability, and pharmacokinetic and pharmacodynamic profile of long-acting rilpivirine.We did a phase 1 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b507935f79f377893bf7eebab229db5a
https://doi.org/10.1016/s2352-3018(16)30113-8
https://doi.org/10.1016/s2352-3018(16)30113-8
Autor:
Nicola Richardson-Harman, Jarret Engstrom, Ian Michael McGowan, Saye Khoo, Rhonda M. Brand, Cory Shetler, Laura Else, David Back, Charlene S. Dezzutti, Urvi M. Parikh, Aaron Siegel, Ross D. Cranston, Peter Williams, Kaleab Z. Abebe, Deidre Egan, James E. Egan, Ron Stall
Publikováno v:
AIDS RESEARCH AND HUMAN RETROVIRUSES
The MWRI-01 study characterized the safety, acceptability, pharmacokinetic (PK), and pharmacodynamic (PD) profile of rilpivirine (RPV) long acting (LA) in a model of preexposure prophylaxis (PrEP). Prospective, open-label Phase 1 study. The safety an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dca07f1c92855b3e921daefab4d161f
Autor:
Timothy Frasca, Jarret Engstrom, Kathryn Duffill, Jill L. Schwartz, Seo Young Park, Rhonda M. Brand, Ian McGowan, Cindy Jacobson, Curtis Dolezal, Aaron Siegel, Irma Febo, Alexyi Nikiforov, Cheng-Shiun Leu, Kenneth H. Mayer, Ross D. Cranston, Alex Carballo-Diéguez, Rebecca Giguere
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158310 (2016)
PLoS ONE
PLoS ONE
OBJECTIVESThe purpose of Project Gel was to determine the safety and acceptability of rectal microbicides in young men who have sex with men (MSM) and transgender women (TGW) at risk of HIV infection.METHODSMSM and TGW aged 18-30 years were enrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051423b67751a40a380189aac97f73d3
http://europepmc.org/articles/PMC4928823?pdf=render
http://europepmc.org/articles/PMC4928823?pdf=render
Autor:
Randall E. Brand, Amanda Zehmisch, Richard H. Duerr, Carol Mitchell, Jarret Engstrom, Aaron Siegel, Stacey Edick, Ashley Myerski, Sherri Karas, Danielle Camp, Ian McGowan, Rhonda M. Brand, Kenneth Palmer
Publikováno v:
Gastroenterology. 152:S965-S966
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b74350d6df51404497f34328b3f32899
https://doi.org/10.1016/s0016-5085(17)33277-8
https://doi.org/10.1016/s0016-5085(17)33277-8