Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease

Autor: Jarren R. Oates, Keisuke Sawada, Daniel A. Giles, Pablo C. Alarcon, Michelle S.M.A. Damen, Sara Szabo, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Senad Divanovic

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionInflammation is a common unifying factor in experimental models of non-alcoholic fatty liver disease (NAFLD) progression. Recent evidence suggests that housing temperature-driven alterations in hepatic inflammation correlate with exacerba

Externí odkaz: https://doaj.org/article/1f1bb9be755e44ee861e3cade70d99e3

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain

Autor: Calvin C. Chan, Isaac T. W. Harley, Paul T. Pfluger, Aurelien Trompette, Traci E. Stankiewicz, Jessica L. Allen, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, Jarren R. Oates, Pablo C. Alarcon, Jessica R. Doll, Matthew J. Flick, Leah M. Flick, Joan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas H. Inge, Stuart P. Weisberg, Sünje J. Pamp, David A. Relman, Randy J. Seeley, Matthias H. Tschöp, Christopher L. Karp, Senad Divanovic

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar i

Externí odkaz: https://doaj.org/article/1874a0fdf3df440c914731f67be8205d

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

Autor: Jarren R. Oates, Melanie C. McKell, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, George S. Deepe, Joseph E. Qualls, Senad Divanovic

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD spectrum of disease involves progression from steatosis (NAFL), to steatohepatitis (NASH), ci

Externí odkaz: https://doaj.org/article/0e1438d604a745b8873224b13b844fb6

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain

Autor: Maria E. Moreno-Fernandez, Michelle S M A Damen, Isaac T.W. Harley, Joan Sanchez-Gurmaches, David A. Relman, Stuart P. Weisberg, Pablo C Alarcon, Matthew J. Flick, Matthias H. Tschöp, Calvin C. Chan, Aurelien Trompette, Rajib Mukherjee, Christopher L. Karp, Randy J. Seeley, Traci E. Stankiewicz, Leah M. Flick, Paul T. Pfluger, Jessica R Doll, Sünje Johanna Pamp, Michael A. Helmrath, Senad Divanovic, Thomas H. Inge, Jarren R Oates, Jessica L. Allen, Rebekah Karns

Publikováno v: Nature Communications
Chan, C C, Harley, I T W, Pfluger, P T, Trompette, A, Stankiewicz, T E, Allen, J L, Moreno-Fernandez, M E, Damen, M S M A, Oates, J R, Alarcon, P C, Doll, J R, Flick, M J, Flick, L M, Sanchez-Gurmaches, J, Mukherjee, R, Karns, R, Helmrath, M, Inge, T H, Weisberg, S P, Pamp, S J, Relman, D A, Seeley, R J, Tschöp, M H, Karp, C L & Divanovic, S 2021, ' A BAFF/APRIL axis regulates obesogenic diet-driven weight gain ', Nature Communications, vol. 12, no. 1, 2911 . https://doi.org/10.1038/s41467-021-23084-1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nat. Commun. 12:2911 (2021)

The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263f2646adf0ada712afeb8ddda964b2
https://doi.org/10.1038/s41467-021-23084-1

1671-P: Pathogenesis of Obesity-Driven Metabolic Sequelae Is Associated with Th17 Metabolic Switch and Inflammatory Hepatic Th17 Cells

Autor: Michelle S M A Damen, Senad Divanovic, Traci E. Stankiewicz, Jessica R Doll, Jarren R Oates, Maria E. Moreno-Fernandez

Publikováno v: Diabetes. 69

Nonalcoholic fatty liver disease (NAFLD) is a major global health issue. Lack of effective therapies to NAFLD is attributed to limited knowledge of disease etiopathogenesis. Emerging evidence reveal key contribution of the Th17 axis in NAFLD. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59f21e5f7f42878317822e703f86a727
https://doi.org/10.2337/db20-1671-p