Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jarred M Whitlock"'
Autor:
Evgenia Leikina, Jarred M Whitlock, Kamran Melikov, Wendy Zhang, Michael P Bachmann, Leonid Chernomordik
Publikováno v:
eLife, Vol 13 (2024)
The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells – gener
Externí odkaz:
https://doaj.org/article/649badd4261f4a4283595ce59b151829
Publikováno v:
eLife, Vol 4 (2015)
Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets. ANO6/TMEM16F has been shown to be essential for Ca2+-depend
Externí odkaz:
https://doaj.org/article/5549572609ba4bd18256773581c27d21
Autor:
Jarred M. Whitlock, Evgenia Leikina, Kamran Melikov, Luis Fernandez De Castro, Sandy Mattijssen, Richard J. Maraia, Michael T. Collins, Leonid V. Chernomordik
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Bone maintenance in health and disease depends on bone-resorbing osteoclasts. Whitlock et al. demonstrate that an RNA chaperon -La protein- lives a second life as a key regulator of osteoclast size and function, suggesting a new therapeutic target.
Externí odkaz:
https://doaj.org/article/76a9ba73d9af473590bc2dc736ad512f
Autor:
Jarred M. Whitlock, Luis F. de Castro, Michael T. Collins, Leonid V. Chernomordik, Alison M. Boyce
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106470- (2023)
Summary: Elucidating a basic blueprint of osteoclast-osteoblast coordination in skeletal remodeling and understanding how this coordination breaks down with age and disease is essential for addressing the growing skeletal health problem in our aging
Externí odkaz:
https://doaj.org/article/41e47cbf2475412a8a4b8000d9ae1202
Autor:
Gonen Golani, Evgenia Leikina, Kamran Melikov, Jarred M. Whitlock, Dilani G. Gamage, Gracia Luoma-Overstreet, Douglas P. Millay, Michael M. Kozlov, Leonid V. Chernomordik
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore
Externí odkaz:
https://doaj.org/article/683f78c9584c4f6da8fc976af9832ff6
Autor:
Jarred M. Whitlock, Luis F. de Castro, Michael T. Collins, Leonid V. Chernomordik, Alison M. Boyce
Metabolic bone diseases are a collection of disorders resulting in diminished skeletal integrity and changes in bone mass due to perturbations in the life-long process of bone remodeling. Perturbations in the number, size and nuclear multiplicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be41e9e57c30773fe2616fd77a41031
https://doi.org/10.1101/2022.10.27.514052
https://doi.org/10.1101/2022.10.27.514052
Autor:
Luis F de Castro, Jarred M Whitlock, Zachary Michel, Kristen Pan, Jocelyn Taylor, Vivian Szymczuk, Sriram S Paravastu, Babak Saboury, Georgios Z Papadakis, Leonid V Chernomordik, Xiaobai Li, Kelly Milligan, Brendan Boyce, Scott Paul, Daniel Martin, Michael T Collins, Alison M Boyce
BACKGROUNDFibrous dysplasia (FD) is a rare, disabling disease with no established treatments. Growing evidence supports inhibiting the pro-osteoclastic factor receptor activator of nuclear Kappa-B ligand (RANKL) as a potential treatment strategy. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6122bcc7ba41c8e0d98f47e640f2e222
https://doi.org/10.1101/2022.10.24.22281375
https://doi.org/10.1101/2022.10.24.22281375
Autor:
Jarred M. Whitlock
Publikováno v:
Journal of General Physiology. 153
Intracellular pH joins the regulatory apparatus of the TMEM16 scramblase module.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e0899c32109fdc02a89dbc095ae4c3
https://doi.org/10.1085/jgp.202012831
https://doi.org/10.1085/jgp.202012831
Autor:
Leonid V. Chernomordik, Gonen Golani, Dilani G. Gamage, Gracia Luoma-Overstreet, Douglas P. Millay, Michael M. Kozlov, Evgenia Leikina, Jarred M. Whitlock, Kamran Melikov
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Myomerger is a muscle-specific membrane protein involved in formation of multinucleated muscle cells by mediating the transition from the early hemifusion stage to complete fusion. Here, we considered the physical mechanism of the Myomerger action ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954cc281a33dac0b1498a7b3ad220aee
http://europepmc.org/articles/PMC7820291
http://europepmc.org/articles/PMC7820291
Publikováno v:
The Journal of General Physiology
Limb-girdle muscular dystrophy type 2L arises from mutations in the anoctamin ANO5, whose role in muscle physiology is unknown. Whitlock et al. show that loss of ANO5 perturbs phosphatidylserine exposure and cell–cell fusion in muscle precursor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440a10ac9d0aa9300b6ec93c0d7732bb
https://doi.org/10.1085/jgp.201812097
https://doi.org/10.1085/jgp.201812097