Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jaroslaw Maciejewski"'
Autor:
David Dingli, Carlos De Castro III, Jamie Koprivnikar, Austin Kulasekararaj, Jaroslaw Maciejewski, Brian Mulherin, Jens Panse, Vinod Pullarkat, Alexander Röth, Jamile Shammo, Louis Terriou, Ilene Weitz, Irina Yermilov, Sarah Gibbs, Michael Broder, David Beenhouwer, David Kuter
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTIntroduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, non-malignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, a
Externí odkaz:
https://doaj.org/article/9910639b99bf41af8dfaccc4685e89c0
Autor:
Celia González-Gil, Mireia Morgades, Thaysa Lopes, Francisco Fuster-Tormo, Jesús García-Chica, Ran Zhao, Pau Montesinos, Anna Torrent, Marina Diaz-Beya, Rosa Coll, Lourdes Hermosín, Santiago Mercadal, José González-Campos, Lurdes Zamora, Teresa Artola, Ferran Vall-Llovera, Mar Tormo, Cristina Gil-Cortés, Pere Barba, Andrés Novo, Jordi Ribera, Teresa Bernal, Paula López de Ugarriza, María-Paz Queipo, Pilar Martínez-Sánchez, Alicia Giménez, Teresa González-Martínez, Antonia Cladera, José Cervera, Rosa Fernández-Martín, María Ángeles Ardaiz, María Jesús Vidal, Ángela Baena, Nuria López-Bigas, Anna Bigas, Jaroslaw Maciejewski, Alberto Orfao, Josep Maria Ribera, Eulalia Genescà
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Genetic information has been crucial to understand the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) at diagnosis and at relapse, but still nowadays has a limited value in a clinical context. Few genetic markers are associated with the
Externí odkaz:
https://doaj.org/article/f665c159564e43d48e5cdc5fc6bc2db5
Autor:
Kenneth Walsh, Nalini Raghavachari, Candace Kerr, Alexander G. Bick, Steven R. Cummings, Todd Druley, Cynthia E. Dunbar, Giulio Genovese, Margaret A. Goodell, Siddhartha Jaiswal, Jaroslaw Maciejewski, Pradeep Natarajan, Anastasia V. Shindyapina, Alan R. Shuldiner, Erik B. Van Den Akker, Jan Vijg
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Aging is characterized by increased mortality, functional decline, and exponential increases in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological disease, respiratory disease, etc. Though the role of aging in thes
Externí odkaz:
https://doaj.org/article/91cc6f1fb0f44f728c443e64a1e07a92
Publikováno v:
Cancers, Vol 13, Iss 17, p 4418 (2021)
Large Granular Lymphocyte Leukemia (LGLL) is a rare, chronic lymphoproliferative disorder of effector cytotoxic T-cells, and less frequently, natural killer (NK) cells. The disease is characterized by an indolent and often asymptomatic course. Howeve
Externí odkaz:
https://doaj.org/article/744612ae35c64c2fa9fc932b57177d4c
Autor:
Thomas Cluzeau, Kathy L. McGraw, Brittany Irvine, Erico Masala, Lionel Ades, Ashley A. Basiorka, Jaroslaw Maciejewski, Patrick Auberger, Sheng Wei, Pierre Fenaux, Valeria Santini, Alan List
Publikováno v:
Haematologica, Vol 102, Iss 12 (2017)
Accumulating evidence implicates innate immune activation in the pathobiology of myelodysplastic syndromes. A key myeloid-related inflammatory protein, S100A9, serves as a Toll-like receptor ligand regulating tumor necrosis factor-α and interleukin-
Externí odkaz:
https://doaj.org/article/2427373ff50e41a9a337710595716baf
Autor:
Elaine M. Sloand, Matthew J. Olnes, Barbara Weinstein, Colin Wu, Jaroslaw Maciejewski, Phillip Scheinberg, Neal S. Young
Publikováno v:
Haematologica, Vol 95, Iss 3 (2010)
Background Pure red cell aplasia and moderate aplastic anemia are marrow failure states with an immune pathogenesis. Previously, we described short-term improvements in blood counts in two pilot studies treating moderate aplastic anemia (mAA) and pur
Externí odkaz:
https://doaj.org/article/d436493eab174cea81bcc7521da195f2
Autor:
Yogen Saunthararajah, Tomas Radivoyevitch, Jaroslaw Maciejewski, Ramon Tiu, Mikkael A. Sekeres, Kory J. Engelke, Yonghua Ling, Kenneth Chan, Joseph Covey, Pramod Terse, Ali Tabarroki, Valeria Visconte, Xiaorong Gu, Quteba Ebrahem, Ania Jankowska, Reda Z. Mahfouz
Purpose: The cytidine analogs 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), produce a molecular epigenetic effect, depletion of DNA-methyltransferase 1 (DNMT1). This action is S-phase dependent. Hence, genetic factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373c9f8453963162b9091ebec5310cce
https://doi.org/10.1158/1078-0432.c.6521568
https://doi.org/10.1158/1078-0432.c.6521568
Autor:
Yogen Saunthararajah, Tomas Radivoyevitch, Jaroslaw Maciejewski, Ramon Tiu, Mikkael A. Sekeres, Kory J. Engelke, Yonghua Ling, Kenneth Chan, Joseph Covey, Pramod Terse, Ali Tabarroki, Valeria Visconte, Xiaorong Gu, Quteba Ebrahem, Ania Jankowska, Reda Z. Mahfouz
PDF file - 297K, Figure S1: CDA mRNA expression in various human tissues. Figure S2: CDA mRNA expression in primary cancer cells. Figure S3: Incidence of MDS in the United States.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec346f909f91c8916a876860d6b3b3
https://doi.org/10.1158/1078-0432.22449147
https://doi.org/10.1158/1078-0432.22449147
Autor:
Olisaemeka D. Ogbue, Waled S. Bahaj, tariq kewan, Ramsha Ahmed, Danai Dima, Nakisha Williams, Arda Durmaz, Valeria Visconte, Sara Maskal, Carmelo Gurnari, rosenblatt steven, Jaroslaw Maciejewski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd5a4cdb453913bf5f5fde2cc677399
https://doi.org/10.2139/ssrn.4420771
https://doi.org/10.2139/ssrn.4420771
Publikováno v:
Leukemia. 36:601-612
Novel targeted therapeutics alone or in rational combinations are likely to dominate the future management of various hematological neoplasms. However, the challenges currently faced are the molecular heterogeneity in driver lesions and genetic plast