Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jaroslaw Dziadek"'
Autor:
Ahmed Sabt, Maha-Hamadien Abdulla, Manal S. Ebaid, Jakub Pawełczyk, Hayam A. Abd El Salam, Ninh The Son, Nguyen Xuan Ha, Mansoor-Ali Vaali Mohammed, Thamer Traiki, Ahmed E. Elsawi, Bozena Dziadek, Jaroslaw Dziadek, Wagdy M. Eldehna
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The spread of drug-resistant tuberculosis strains has become a significant economic burden globally. To tackle this challenge, there is a need to develop new drugs that target specific mycobacterial enzymes. Among these enzymes, InhA, which is crucia
Externí odkaz:
https://doaj.org/article/0658c0c8b7e04d27a01d52d5c7ce9061
Autor:
Katarzyna Krysztopa-Grzybowska, Jakub Lach, Maciej Polak, Dominik Strapagiel, Jaroslaw Dziadek, Marcin Olszewski, Aleksandra A. Zasada, Aniela Darlińska, Anna Lutyńska, Ewa Augustynowicz-Kopeć
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Currently, tuberculosis immunoprophylaxis is based solely on Bacillus Calmette-Guérin (BCG) vaccination, and some of the new potential tuberculosis vaccines are based on the BCG genome. Therefore, it is reasonable to analyze the genomes of
Externí odkaz:
https://doaj.org/article/754b643f62ca49a2b57a83ff8cc4ca84
Autor:
Izabela Szulc-Kielbik, Jakub Pawelczyk, Michal Kielbik, Laurent Kremer, Jaroslaw Dziadek, Magdalena Klink
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-11 (2017)
Abstract Background Although mycobacterial glycolipids are among the first-line molecules involved in host–pathogen interactions, their contribution in virulence remains incomplete. Mycobacterium marinum is a waterborne pathogen of fish and other e
Externí odkaz:
https://doaj.org/article/8d6b2d40f72744a6b39bad2dc15f0911
Autor:
Izabela Szulc-Kielbik, Michal Kielbik, Patrycja Przygodzka, Anna Brzostek, Jaroslaw Dziadek, Magdalena Klink
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
This study tested the hypothesis that Mycobacterium tuberculosis (Mtb) uses a cholesterol oxidase enzyme (ChoD) to suppress a toll-like receptor type 2- (TLR2-) dependent signalling pathway to modulate macrophages’ immune response. We investigated
Externí odkaz:
https://doaj.org/article/50b1b22965374f36ae054ee34ba0b2d5
Autor:
Purushotham Gorla, Renata Plocinska, Krishna Sarva, Akash T. Satsangi, Emmanuel Pandeeti, Robert Donnelly, Jaroslaw Dziadek, Malini Rajagopalan, Murty V. Madiraju
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The biological processes regulated by the essential response regulator MtrA and the growth conditions promoting its activation in Mycobacterium tuberculosis, a slow grower and pathogen, are largely unknown. Here, using a gain-of-function mutant, MtrA
Externí odkaz:
https://doaj.org/article/0e8d7f1890ab4167bed2470ebc99d13a
Autor:
Bozena Dziadek, Anna Brzostek, Marcin Grzybowski, Marek Fol, Agnieszka Krupa, Jakub Kryczka, Przemyslaw Plocinski, Anna Kurdowska, Jaroslaw Dziadek
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148030 (2016)
Mycobacterium tuberculosis is an extremely successful intracellular pathogen that has evolved a broad spectrum of pathogenic mechanisms that enable its manipulation of host defense elements and its survival in the hostile environment inside phagocyte
Externí odkaz:
https://doaj.org/article/804decca0c8a4befbe5b5f3886c888ab
Autor:
Alina E Minias, Anna M Brzostek, Malgorzata Korycka-Machala, Bozena Dziadek, Piotr Minias, Malini Rajagopalan, Murty Madiraju, Jaroslaw Dziadek
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126260 (2015)
RNases H are involved in the removal of RNA from RNA/DNA hybrids. Type I RNases H are thought to recognize and cleave the RNA/DNA duplex when at least four ribonucleotides are present. Here we investigated the importance of RNase H type I encoding ge
Externí odkaz:
https://doaj.org/article/bdea6419b30e4d7ab256481b0d20466b
Autor:
Agnieszka Krupa, Marek Fol, Bozena R. Dziadek, Ewa Kepka, Dominika Wojciechowska, Anna Brzostek, Agnieszka Torzewska, Jaroslaw Dziadek, Robert P. Baughman, David Griffith, Anna K. Kurdowska
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL
Externí odkaz:
https://doaj.org/article/d134461b62d447c6afd185eba5c851e4
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115521 (2015)
RNase HII removes RNA from RNA/DNA hybrids, such as single ribonucleotides and RNA primers generated during DNA synthesis. Both, RNase HII substrates and RNase HII deficiency have been associated with genome instability in several organisms, and geno
Externí odkaz:
https://doaj.org/article/a2ff219b3c6d43b286124dc06ca3913d
Autor:
Malgorzata Korycka-Machala, Marcin Nowosielski, Aneta Kuron, Sebastian Rykowski, Agnieszka Olejniczak, Marcin Hoffmann, Jaroslaw Dziadek
Publikováno v:
Molecules, Vol 22, Iss 1, p 154 (2017)
The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential
Externí odkaz:
https://doaj.org/article/b3e7ce72319742b2ae4a75547fdf8268