Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Autor: Simon J. Allison, Jaroslaw Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a ra

Externí odkaz: https://doaj.org/article/5894d27a002d445592149ac898aef1be

Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney

Autor: Katharina, Dulias, M George B, Foody, Pierre, Justeau, Marina, Silva, Rui, Martiniano, Gonzalo, Oteo-García, Alessandro, Fichera, Simão, Rodrigues, Francesca, Gandini, Alison, Meynert, Kevin, Donnelly, Timothy J, Aitman, Andrew, Chamberlain, Olivia, Lelong, George, Kozikowski, Dominic, Powlesland, Clive, Waddington, Valeria, Mattiangeli, Daniel G, Bradley, Jaroslaw, Bryk, Pedro, Soares, James F, Wilson, Graeme, Wilson, Hazel, Moore, Maria, Pala, Ceiridwen J, Edwards, Javier, Santoyo-Lopez

Publikováno v: 2022, ' Ancient DNA at the edge of the world : Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney ', Proceedings of the National Academy of Sciences (PNAS), vol. 119, no. 8, e2108001119 . https://doi.org/10.1073/pnas.2108001119

Raw sequencing reads of ancient samples produced for this study have been deposited in the European Nucleotide Archive under accession no. PRJEB46830. Modern mitochondrial genomes generated as part of this study have been deposited in GenBank, access

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fae43b04f58a2ef38fb4bb992e2ad9d
https://doi.org/10.1073/pnas.2108001119

Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations

Autor: Andrzej, Semczuk, Anna, Lorenc, Lechoslaw, Putowski, Konrad, Futyma, Jaroslaw, Bryk, Pawel, Miotla, Ewa, Bartnik

Publikováno v: Oncology reports. 16(5)

Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::751021fc716f8507d8de9348271fd8a6
https://pubmed.ncbi.nlm.nih.gov/17016590

Population structure of Apodemus flavicollis and comparison to Apodemus sylvaticus in northern Poland based on RAD-seq

Autor: Maria Luisa Martin Cerezo, Marek Kucka, Karol Zub, Yingguang Frank Chan, Jarosław Bryk

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-14 (2020)

Abstract Background Mice of the genus Apodemus are one the most common mammals in the Palaearctic region. Despite their broad range and long history of ecological observations, there are no whole-genome data available for Apodemus, hindering our abil

Externí odkaz: https://doaj.org/article/e26e2f6d20dd433db091364d766d4b30

Honeybee Cognition as a Tool for Scientific Engagement

Autor: Jai A. Denton, Ivan Koludarov, Michele Thompson, Jarosław Bryk, Mariana Velasque

Publikováno v: Insects, Vol 12, Iss 9, p 842 (2021)

Apis mellifera (honeybees) are a well-established model for the study of learning and cognition. A robust conditioning protocol, the olfactory conditioning of the proboscis extension response (PER), provides a powerful but straightforward method to e

Externí odkaz: https://doaj.org/article/c077812f0f0c4ed9942bb629d4e8508a