Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jaroslava Trnovska"'
Autor:
Jaroslava Trnovská, Jan Šilhavý, Ondřej Kuda, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Vojtěch Škop, Olena Oliyarnyk, Ludmila Kazdová, Martin Haluzík, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179063 (2017)
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndr
Externí odkaz:
https://doaj.org/article/8f616313fe6841dd9e8fec56bd41364a
Autor:
Vojt ch Škop, Hana Malínská, Jaroslava Trnovská, Martina Hüttl, Monika Cahová, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Martin Burian, Olena Oliyarnyk, Ludmila Kazdová
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122768 (2015)
While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. Therefore, we used hereditary hypertriaclyglycerolemic (HHTg) rats as a unique
Externí odkaz:
https://doaj.org/article/1b55067b45e14fe1955b476df6722118
Autor:
Tereza Tykvartova, Matus Miklovic, Martin Kotrc, Petra Skaroupkova, Ludmila Kazdova, Jaroslava Trnovska, Vojtech Skop, Michal Kolar, Jiri Novotny, Vojtech Melenovsky
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract While phosphodiesterase‐5 inhibition (PED5i) may prevent hypertrophy and failure in pressure‐overloaded heart in an experimental model, the impact of PDE5i on volume‐overload (VO)‐induced hypertrophy is unknown. It is also unclear wh
Externí odkaz:
https://doaj.org/article/d062805e3709438687a940351a7af7a8
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activit
Externí odkaz:
https://doaj.org/article/e1a97d3a7b444e588a78bce984149ca2
Autor:
BARBORA JUDITA KASPEROVA, MILOS MRAZ, ONDREJ KUDA, TOMAS CAJKA, DANIEL HLAVÁCEK, JAKUB MAHRÍK, LUCIE TOMANOVÁ, IVANA LANKOVA, SONA STEMBERKOVA HUBACKOVA, IVETA PLEYEROVA, KATERINA ROSOLOVÁ, PETR SVOBODA, JAROSLAVA TRNOVSKA, PETER NOVODVORSKY, PETER IVAK, VOJTECH MELENOVSKY, IVAN NETUKA, MARTIN HALUZIK
Publikováno v:
Diabetes. 71
The exact mechanisms behind favorable metabolic and cardioprotective effects of SGLT-2 inhibitors (SGLT-2i) are still not fully understood. We performed a complex metabolomic analysis of subcutaneous (SAT) and epicardial (EAT) adipose tissue of heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9d2b872705163e7f919549157e21fd
https://doi.org/10.2337/db22-875-p
https://doi.org/10.2337/db22-875-p
Autor:
Hana Malinska, Olena Oliyarnyk, Helena Pelantová, Irena Markova, Iveta Dvorakova, Magdalena Melčová, Petr Svoboda, Helena Kratochvilova, Vojtech Skop, Katerina Rosolova, Martina Hüttl, Milos Mraz, Barbora Judita Kasperova, Jaroslava Trnovska, Marek Kuzma, Sona Stemberkova-Hubackova, Martin Haluzik
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10606, p 10606 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10606, p 10606 (2021)
(1) Background: empagliflozin, sodium-glucose co-transporter 2 (SGLT-2) inhibitor, is an effective antidiabetic agent with strong cardio- and nephroprotective properties. The mechanisms behind its cardio- and nephroprotection are still not fully clar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80c7d9696ddf299df2f8c27954c13df
http://europepmc.org/articles/PMC8508693
http://europepmc.org/articles/PMC8508693
Autor:
Jaroslava Trnovska, Iveta Dvorakova, Milos Mraz, Martin Haluzik, Peter Ivak, Ivan Netuka, Z Lacinová, Daniel Hlavacek, Barbora Judita Kasperova, Jakub Mahrík
Publikováno v:
Diabetes. 70
Cellular senescence is a novel mechanism suggested to contribute to the development of type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Here, we analyzed the expression of senescent markers in myocardium and adjacent adipose tissue of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4983610902e36bd8e8cff7ad98fdb703
https://doi.org/10.2337/db21-368-p
https://doi.org/10.2337/db21-368-p
Autor:
Denisa Miklankova, Jaroslava Trnovska, Irena Markova, Martin Poruba, Hana Malinska, Martina Hüttl, Iveta Zapletalova
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4527, p 4527 (2021)
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4527, p 4527 (2021)
Ovarian hormone deficiency leads to increased body weight, visceral adiposity, fatty liver and disorders associated with menopausal metabolic syndrome. To better understand the underlying mechanisms of these disorders in their early phases of develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a64224616a572dbab8ef842c25c9fb2
Autor:
Milos Mraz, Barbora Judita Kasperova, Martin Haluzik, Zdeněk Vilikus, Denisa Haluzikova, Pavel Kysel, Viktorie Hrádková, Radka Petráková Doležalová, Zdeňka Lacinová, Ivana Laňková, Jaroslava Trnovska
Publikováno v:
Nutrients, Vol 12, Iss 2832, p 2832 (2020)
Nutrients
Volume 12
Issue 9
Nutrients
Volume 12
Issue 9
(1) Background: The influence of ketogenic diet on physical fitness remains controversial. We performed a randomized controlled trial to compare the effect of cyclical ketogenic reduction diet (CKD) vs. nutritionally balanced reduction diet (RD) on b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e69af47597c89a9161c27c660784c71
https://www.mdpi.com/2072-6643/12/9/2832
https://www.mdpi.com/2072-6643/12/9/2832
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature communications. 13(1)
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fc39d0b93e345792637ba4b42f6e47
https://pubmed.ncbi.nlm.nih.gov/35387987
https://pubmed.ncbi.nlm.nih.gov/35387987