Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jaroslav Malina"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Some metallo-supramolecular helical assemblies with size, shape, charge and amphipathic architectures similar to short cationic α-helical peptides have been shown to target and stabilise DNA G-quadruplexes (G4s) in vitro and downregulate the express
Externí odkaz:
https://doaj.org/article/14b188dd04c0495880caaa130db1bc10
Publikováno v:
Nucleic Acids Research
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive opti
Publikováno v:
Inorganic Chemistry Frontiers. 9:5597-5606
Dinuclear nickel(ii) supramolecular helicates selectively stabilize DNA G-quadruplexes and suppress G-quadruplex-regulated genes.
Publikováno v:
Chemistry – A European Journal. 27:11682-11692
DNA G-quadruplexes (G4s) were identified within the promoter regions of many proto-oncogenes. Thus, G4s represent attractive targets for cancer therapy and the design and development of new drugs as G4 binders is a very active field of medicinal chem
Autor:
Raphael E. F. Paiva, Erica J. Peterson, Jaroslav Malina, Mary Zoepfl, J. David Hampton, Wyatt E. Johnson, Angelica Graminha, Amine Ourahmane, Michael A. McVoy, Viktor Brabec, Susan J. Berners‐Price, Nicholas P. Farrell
Publikováno v:
Angewandte Chemie. 133:17260-17267
Autor:
Amine Ourahmane, Raphael E. F. de Paiva, Michael A. McVoy, Susan J. Berners-Price, Nicholas Farrell, J. David Hampton, Viktor Brabec, Mary Zoepfl, Erica J. Peterson, Wyatt E. Johnson, Angelica Graminha, Jaroslav Malina
Publikováno v:
Angew Chem Int Ed Engl
Werner's Complex, as a cationic coordination complex (CCC), has hitherto unappreciated biological properties derived from its binding affinity to highly anionic biomolecules such as glycosaminoglycans (GAGs) and nucleic acids. Competitive inhibitor a
Publikováno v:
Inorganic Chemistry Frontiers. 8:3371-3381
DNA G-quadruplex (G4) structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy. Thus, much effort has been devoted to the development of a variety of G4-binding ligands, mostly based on rigid pl
Publikováno v:
Chemistry – A European Journal. 26:16554-16562
Bulges are essential structural elements in nucleic acids. The detection and targeting of bulged DNA sequences are highly important. Small molecules capable of targeting DNA bulges have attracted considerable attention because they cannot only be use
Publikováno v:
Chemistry – A European Journal. 26:8435-8442
RNA bulges represent one of the most common motifs in the RNA secondary structure and serve in a variety of biological functions. Compounds stabilizing RNA bulges are important for probing RNA structure and function and for therapy of some diseases.
Autor:
Jitka Pracharova, Ondrej Hrabina, Hana Kostrhunova, Jaroslav Malina, Viktor Brabec, Peter Scott, Vojtech Novohradsky, Daniel H. Simpson, Nicola J. Rogers
Publikováno v:
Inorganic Chemistry. 59:3304-3311
The water-compatible optically pure metallohelices made by self-assembly of simple nonpeptidic organic components around Fe(II) ions are now recognized as a distinct subclass of helicates that exhibit similar architecture to some natural cationic ant