Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jaroslav Kozak"'
Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Autor:
Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100216- (2024)
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a
Externí odkaz:
https://doaj.org/article/02da55a35360455dbc11c50a0c3d790f
Autor:
Premysl Parenica, Radim Halama, Jakub Flodr, Martin Krejsa, David Mikolášek, Alois Materna, Jaroslav Kozak, Jiri Brozovsky
Publikováno v:
Advances in Engineering Software. 117:59-69
The paper is focused on the numerical modeling of steel bearing elements and their verification using experiment. Currently, for the stress-strain analysis of the elements supporting structures it is possible to use many commercial software systems,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4839f287bb5bda2c0f94420ced492036
https://doi.org/10.1016/j.advengsoft.2017.03.013
https://doi.org/10.1016/j.advengsoft.2017.03.013
Publikováno v:
Procedia Structural Integrity. 13:1539-1544
The article deals with the fatigue damage analysis of aging steel structures. The structure was built in 1920 and is used to operate an outdoor storage of steel rolled products. The structure serves as a support for overhead cranes with a lifting cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9c5ec9f8b356845909aa64b5fbfac5
https://doi.org/10.1016/j.prostr.2018.12.314
https://doi.org/10.1016/j.prostr.2018.12.314
Autor:
Marcela Pávová, Paul Eduardo Reyes-Gutiérrez, Jaroslav Kozák, Juraj Dobiaš, Yevgen Yurenko, Martin Lepšík, Filip Teplý, Jan Weber
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes. Several G-quadruplexes can be formed in the HIV-1 long terminal repeat promoter region and
Externí odkaz:
https://doaj.org/article/dc4ed802e78c41dc9e285b6807d85f86
Autor:
Premysl Parenica, Libor Zidek, Jaroslav Kozak, Jiri Brozovsky, David Mikolášek, Martin Krejsa
Publikováno v:
Applied Mechanics and Materials. :412-417
The paper describes the experimental tests of steel bearing elements, which were aimed at obtaining material, geometric and strength characteristics of the fillet welds. Preparation of experiment consisted in defining of numerical models of tested sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168d4d8829c94702050654c71b3cdf73
https://doi.org/10.4028/www.scientific.net/amm.752-753.412
https://doi.org/10.4028/www.scientific.net/amm.752-753.412
Publikováno v:
BioMed Research International, Vol 2013 (2013)
BioMed Research International
BioMed Research International
The mossPhyscomitrella patensis unique for the high frequency of homologous recombination, haploid state, and filamentous growth during early stages of the vegetative growth, which makes it an excellent model plant to study DNA damage responses. We u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071b5f698eeaebbfe54f9fbdf38f4dfb
https://doi.org/10.1155/2013/535049
https://doi.org/10.1155/2013/535049
Autor:
Dieter Schweizer, Jaroslav Kozak, Gudrun Böhmdorfer, Stefan Ferscha, Reinhard Brunmeir, Viktoria Nizhynska, Karel J. Angelis, Alexander Schleiffer, David P. Kreil
Publikováno v:
The Plant Journal. 67:420-433
DNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17741fa024961129ae3c0711e18a54e
https://doi.org/10.1111/j.1365-313x.2011.04604.x
https://doi.org/10.1111/j.1365-313x.2011.04604.x
Autor:
Olga Pontes, Gloria Michelle Ducasa, Jaroslav Kozak, Claudio Capitao, José A da Costa-Nunes, Pedro Costa-Nunes, Karel J. Angelis
Publikováno v:
BMC Plant Biology
Background The RAD21 cohesin plays, besides its well-recognised role in chromatid cohesion, a role in DNA double strand break (dsb) repair. In Arabidopsis there are three RAD21 paralog genes (AtRAD21.1, AtRAD21.2 and AtRAD21.3), yet only AtRAD21.1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078917f544fb1de5235a60bd5fad9b85
https://doi.org/10.1186/s12870-014-0353-9
https://doi.org/10.1186/s12870-014-0353-9
Autor:
Marcela Holá, Karel J. Angelis, Nathalie Vrielynck, Jaroslav Kozak, Fabien Nogué, Florence Charlot, Andrew C. Cuming, Didier G. Schaefer, Yasuko Kamisugi
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2012, 40 (8), pp.3496-3510. ⟨10.1093/nar/gkr1272⟩
Nucleic Acids Research 8 (40), 3496-3510. (2012)
Nucleic acids research
Nucleic Acids Research, Oxford University Press, 2012, 40 (8), pp.3496-3510. ⟨10.1093/nar/gkr1272⟩
Nucleic Acids Research 8 (40), 3496-3510. (2012)
Nucleic acids research
The moss Physcomitrella patens is unique among plant models for the high frequency with which targeted transgene insertion occurs via homologous recombination. Transgene integration is believed to utilize existing machinery for the detection and repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc81054fca43798a4c3cd68508551212
https://hal.archives-ouvertes.fr/hal-01003435/document
https://hal.archives-ouvertes.fr/hal-01003435/document
Autor:
Christopher E. West, Jaroslav Kozak, José A. da Costa-Nunes, Karel J. Angelis, Charles I. White
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2009, 8 (3), pp.413-9. ⟨10.1016/j.dnarep.2008.11.012⟩
DNA Repair, 2009, 8 (3), pp.413-9. ⟨10.1016/j.dnarep.2008.11.012⟩
DNA Repair, Elsevier, 2009, 8 (3), pp.413-9. ⟨10.1016/j.dnarep.2008.11.012⟩
DNA Repair, 2009, 8 (3), pp.413-9. ⟨10.1016/j.dnarep.2008.11.012⟩
International audience; DNA double strand breaks (DSBs) are one of the most cytotoxic forms of DNA damage and must be repaired by recombination, predominantly via non-homologous joining of DNA ends (NHEJ) in higher eukaryotes. However, analysis of DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46acc4d765c0590900345ca6ea60066
https://pubmed.ncbi.nlm.nih.gov/19070688
https://pubmed.ncbi.nlm.nih.gov/19070688