Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Jaroslav Cermak"'
Autor:
Jaroslav Cermak
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionInherited bone marrow failure (IBMF) syndromes are caused by mutations forming pathologic germline variants resulting in the production of defective hematopoietic stem cells (HSC) and in congenital failure in the production of one or more
Externí odkaz:
https://doaj.org/article/c1db6e8468114b0d9ea1a36e356682f4
Autor:
Iva Trsova, Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Aleš Holoubek, Karolina Staflova, Lucie Janstova, Sarka Vanikova, Katarina Szikszai, Jiri Klema, Petr Rysavy, Monika Belickova, Monika Kaisrlikova, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Jan Fric, Jan Musil, Michaela Dostalova Merkerova
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2565-2583 (2023)
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we investigated the impact of SF3B1 mutations on circR
Externí odkaz:
https://doaj.org/article/cf124e1e1eda474f8d617a5629fc916b
Publikováno v:
Turkish Journal of Hematology, Vol 39, Iss 4, Pp 272-274 (2022)
Externí odkaz:
https://doaj.org/article/3086508766c34a8a891c49d10f4f111c
Autor:
Klara Pecankova, Pavla Pecherkova, Zdenka Gasova, Zofie Sovova, Tomas Riedel, Eliézer Jäger, Jaroslav Cermak, Pavel Majek
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Background Extracellular vesicles are released into body fluids from the majority of, if not all, cell types. Because their secretion and specific cargo (e.g., proteins) varies according to pathology, extracellular vesicles may prove a rich source of
Externí odkaz:
https://doaj.org/article/11b90946a2fa49f9a3b238428ed6da86
Autor:
Pedro da Silva-Coelho, Leonie I. Kroeze, Kenichi Yoshida, Theresia N. Koorenhof-Scheele, Ruth Knops, Louis T. van de Locht, Aniek O. de Graaf, Marion Massop, Sarah Sandmann, Martin Dugas, Marian J. Stevens-Kroef, Jaroslav Cermak, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Theo de Witte, Nicole M. A. Blijlevens, Petra Muus, Gerwin Huls, Bert A. van der Reijden, Seishi Ogawa, Joop H. Jansen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Myelodysplastic syndromes are a broad group of haematopoietic malignancies that often progress to acute myeloid leukaemia. Here, the authors show that linear and branched evolution occurs within myelodysplastic syndrome and these patterns can be impa
Externí odkaz:
https://doaj.org/article/15e723d7aa454140a35f949fbaeac555
Autor:
Hana Votavova, Zuzana Urbanova, David Kundrat, Michaela Dostalova Merkerova, Martin Vostry, Monika Hruba, Jaroslav Cermak, Monika Belickova
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 41 (2021)
Deferasirox (DFX) is an oral iron chelator used to reduce iron overload (IO) caused by frequent blood cell transfusions in anemic myelodysplastic syndrome (MDS) patients. To study the molecular mechanisms by which DFX improves outcome in MDS, we anal
Externí odkaz:
https://doaj.org/article/4e59932ca0a745b3bfec0a888822a382
Publikováno v:
Turkish Journal of Hematology, Vol 34, Iss 1, Pp 111-113 (2017)
Externí odkaz:
https://doaj.org/article/992766d419f34bd69e9a280ce2b12e41
Autor:
Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Katarina Szikszai, Monika Belickova, Pavla Pecherkova, Jiri Klema, Jitka Vesela, Monika Hruba, Jaroslav Cermak, Tereza Hrdinova, Matyas Krijt, Jan Valka, Anna Jonasova, Michaela Dostalova Merkerova
Publikováno v:
Cells, Vol 9, Iss 4, p 794 (2020)
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders with large heterogeneity at the clinical and molecular levels. As diagnostic procedures shift from bone marrow biopsies towards less invasive techniques, circulating small noncodin
Externí odkaz:
https://doaj.org/article/6694200bbc214c129172b7000b61d9f9
Autor:
Louise de Swart, Chloé Reiniers, Timothy Bagguley, Corine van Marrewijk, David Bowen, Eva Hellström-Lindberg, Aurelia Tatic, Argiris Symeonidis, Gerwin Huls, Jaroslav Cermak, Arjan A. van de Loosdrecht, Hege Garelius, Dominic Culligan, Mac Macheta, Michail Spanoudakis, Panagiotis Panagiotidis, Marta Krejci, Nicole Blijlevens, Saskia Langemeijer, Jackie Droste, Dorine W. Swinkels, Alex Smith, Theo de Witte
Publikováno v:
Haematologica, Vol 103, Iss 1 (2018)
Red blood cell transfusions remain one of the cornerstones in supportive care of lower-risk patients with myelodysplastic syndromes. We hypothesized that patients develop oxidant-mediated tissue injury through the formation of toxic iron species, cau
Externí odkaz:
https://doaj.org/article/b1a31300b6a84686a4b8302f807f6d32
Autor:
Michaela Dostalova Merkerova, Hana Remesova, Zdenek Krejcik, Nikoleta Loudova, Andrea Hrustincova, Katarina Szikszai, Jaroslav Cermak, Anna Jonasova, Monika Belickova
Publikováno v:
Cells, Vol 7, Iss 9, p 138 (2018)
The DLK1–DIO3 region contains a large miRNA cluster, the overexpression of which has previously been associated with myelodysplastic syndromes (MDS). To reveal whether this overexpression is epigenetically regulated, we performed an integrative ana
Externí odkaz:
https://doaj.org/article/db4f5dfe21ed4b1bbfe2ccc30bd0d202