Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Jaroslav, Kuneš"'
Autor:
Tomáš David, Miroslava Šedinová, Aneta Myšková, Jaroslav Kuneš, Lenka Maletínská, Radek Pohl, Martin Dračínský, Helena Mertlíková-Kaiserová, Karel Čížek, Blanka Klepetářová, Miroslava Litecká, Antonín Kaňa, David Sýkora, Adam Jaroš, Michal Straka, Miloslav Polasek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction of the chelator DOTA four decades ago, there has been only limited progress on i
Externí odkaz:
https://doaj.org/article/9f1742eaa53148b680d760f9ec59e3ba
Autor:
Gabriela Svobodová, Michaela Šadibolová, Eva Velecká, Lucia Mráziková, Petra Vaculová, Petra Matoušková, Jaroslav Kuneš, Lenka Maletínská, Iva Boušová
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1371 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD), one of the leading causes of chronic liver disorders, is characterized by hepatic lipid accumulation. MASLD causes alterations in the antioxidant defense system, lipid, and drug metabo
Externí odkaz:
https://doaj.org/article/423a63e8e63d4b019cc0d0d56c0ae851
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractPeptides, as potential therapeutics continue to gain importance in the search for active substances for the treatment of numerous human diseases, some of which are, to this day, incurable. As potential therapeutic drugs, peptides have many fa
Externí odkaz:
https://doaj.org/article/a293360120f34103b9a3a67fad60f323
Autor:
Lucia Mráziková, Silvie Hojná, Andrea Pačesová, Lucie Hrubá, Veronika Strnadová, Barbora Neprašová, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Publikováno v:
Nutrition & Diabetes, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Background/Objective Anorexigenic palmitoylated prolactin-releasing peptide (palm11-PrRP) is able to act centrally after peripheral administration in rat and mouse models of obesity, type 2 diabetes mellitus and/or neurodegeneration. Functio
Externí odkaz:
https://doaj.org/article/47e51a697f6640b78f6f4c5e6267044a
Autor:
Miroslava Kacířová, Blanka Železná, Michaela Blažková, Martina Holubová, Andrea Popelová, Jaroslav Kuneš, Blanka Šedivá, Lenka Maletínská
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-22 (2021)
Abstract Background Obesity leads to low-grade inflammation in the adipose tissue and liver and neuroinflammation in the brain. Obesity-induced insulin resistance (IR) and neuroinflammation seem to intensify neurodegeneration including Alzheimer’s
Externí odkaz:
https://doaj.org/article/920a35cde9034156a65356969c229d50
Autor:
Helena Pelantová, Petra Tomášová, Blanka Šedivá, Barbora Neprašová, Lucia Mráziková, Jaroslav Kuneš, Blanka Železná, Lenka Maletínská, Marek Kuzma
Publikováno v:
Metabolites, Vol 13, Iss 4, p 552 (2023)
Zucker fatty (fa/fa) rats represent a well-established and widely used model of genetic obesity. Because previous metabolomic studies have only been published for young fa/fa rats up to 20 weeks of age, which can be considered early maturity in male
Externí odkaz:
https://doaj.org/article/13ee5ff5b92945a29210d1561a42823f
Autor:
Lucia Mráziková, Barbora Neprašová, Anna Mengr, Andrea Popelová, Veronika Strnadová, Lucie Holá, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Obesity and type 2 diabetes mellitus (T2DM) are preconditions for the development of metabolic syndrome, which is reaching pandemic levels worldwide, but there are still only a few anti-obesity drugs available. One of the promising tools for the trea
Externí odkaz:
https://doaj.org/article/3912e19852a7429d857bae0d25a4764e
Autor:
Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská
Publikováno v:
Clinical Science. 137:847-862
A previous study on neuropeptide FF receptor 2 (NPFFR2)-deficient mice has demonstrated that NPFFR2 is involved in the control of energy balance and thermogenesis. Here, we report on the metabolic impact of NPFFR2 deficiency in male and female mice t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9069996d9447ee92d756ce14bbeb4f4c
https://doi.org/10.1042/cs20220880
https://doi.org/10.1042/cs20220880
Autor:
Andrea, Pačesová, Martina, Holubová, Lucie, Hrubá, Veronika, Strnadová, Barbora, Neprašová, Helena, Pelantová, Marek, Kuzma, Blanka, Železná, Jaroslav, Kuneš, Lenka, Maletínská
Publikováno v:
Aging. 14:7300-7327
The most important risk factor for the development of sporadic Alzheimer's disease (AD) is ageing. Senescence accelerated mouse prone 8 (SAMP8) is a model of sporadic AD, with senescence accelerated resistant mouse (SAMR1) as a control. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957343bf14b4d7b877ad8a0ecf6c108f
https://doi.org/10.18632/aging.204284
https://doi.org/10.18632/aging.204284
Autor:
Lucia Mráziková, Silvie Hojná, Petra Vaculová, Štěpán Strnad, Vladimír Vrkoslav, Helena Pelantová, Marek Kuzma, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Publikováno v:
Nutrients; Volume 15; Issue 2; Pages: 280
Prolactin-releasing peptide (PrRP) is an anorexigenic neuropeptide that has potential for the treatment of obesity and its complications. Recently, we designed a palmitoylated PrRP31 analog (palm11-PrRP31) that is more stable than the natural peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcb7cd42ae3d49031218669db9020c4