Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Jarosław Ruczyński"'
1
Akademický článek
Solid Phase Synthesis and TAR RNA-Binding Activity of Nucleopeptides Containing Nucleobases Linked to the Side Chains via 1,4-Linked-1,2,3-triazole
Autor: Piotr Mucha, Małgorzata Pieszko, Irena Bylińska, Wiesław Wiczk, Jarosław Ruczyński, Katarzyna Prochera, Piotr Rekowski
Publikováno v: Biomedicines, Vol 12, Iss 3, p 570 (2024)
Nucleopeptides (NPs) represent synthetic polymers created by attaching nucleobases to the side chains of amino acid residues within peptides. These compounds amalgamate the characteristics of peptides and nucleic acids, showcasing a unique ability to
Externí odkaz: https://doaj.org/article/89d9b7d893a14d4aa80d008974ef2add
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2
Akademický článek
Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouseResearch in context
Autor: Piotr Sass, Paweł Sosnowski, Justyna Podolak-Popinigis, Bartosz Górnikiewicz, Jolanta Kamińska, Milena Deptuła, Ewa Nowicka, Anna Wardowska, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski, Natalia Filipowicz, Alina Mieczkowska, Grażyna Peszyńska-Sularz, Łukasz Janus, Piotr Skowron, Artur Czupryn, Piotr Mucha, Arkadiusz Piotrowski, Sylwia Rodziewicz-Motowidło, Michał Pikuła, Paweł Sachadyn
Publikováno v: EBioMedicine, Vol 46, Iss , Pp 317-329 (2019)
Background: Most studies on regenerative medicine focus on cell-based therapies and transplantations. Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensively investigated in regenerative researc
Externí odkaz: https://doaj.org/article/8eda6354883a47edbc0359b12e94f43b
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3
Akademický článek
Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin
Autor: Jarosław Ruczyński, Izabela Rusiecka, Katarzyna Turecka, Agnieszka Kozłowska, Magdalena Alenowicz, Iwona Gągało, Anna Kawiak, Piotr Rekowski, Krzysztof Waleron, Ivan Kocić
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract In the presented study, transportan 10 (TP10), an amphipathic cell penetrating peptide (CPP) with high translocation activity, was conjugated with vancomycin (Van), which is known for poor access to the intracellular bacteria and the brain.
Externí odkaz: https://doaj.org/article/6ab41cdc1a11452badeea81901679a26
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4
Akademický článek
Interaction of Arginine-Rich Cell-Penetrating Peptides with an Artificial Neuronal Membrane
Autor: Piotr Mucha, Emilia Sikorska, Piotr Rekowski, Jarosław Ruczyński
Publikováno v: Cells, Vol 11, Iss 10, p 1638 (2022)
Arginine-rich cell-penetrating peptides (RRCPPs) exhibit intrinsic neuroprotective effects on neurons injured by acute ischemic stroke. Conformational properties, interaction, and the ability to penetrate the neural membrane are critical for the neur
Externí odkaz: https://doaj.org/article/dd0e86fc129941b1bf2fd09994ed27eb
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6
PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
Autor: Jarosław Ruczyński, Paweł Sachadyn, Michał Pikuła, Izabela Puchalska, Piotr Mucha, Piotr Rekowski, Magdalena J. Ślusarz, Piotr Rogujski, Jarosław Mazuryk, Arkadiusz Piotrowski, Piotr M. Skowron, Marta Barbara Wiśniewska, R. Platek, Łukasz Janus, Artur Czupryn, Sylwia Rodziewicz-Motowidło, Kamil Koziński
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 6086, p 6086 (2021)
Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230c9c50f8b2feadc5cd88e6304dbedd
http://europepmc.org/articles/PMC8200211
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8
TP10-Dopamine Conjugate as a Potential Therapeutic Agent in the Treatment of Parkinson’s Disease
Autor: Ewelina Backtrog, Piotr Rekowski, Izabela Rusiecka, Jarosław Ruczyński, Agnieszka Kozłowska, Piotr Mucha, Ivan Kocić
Publikováno v: Bioconjugate Chemistry. 30:760-774
Parkinson's disease (PD) is a common progressive neurodegenerative disorder for which the current treatment is not fully satisfactory. One of the major drawbacks of current PD therapy is poor penetration of drugs across the blood-brain barrier (BBB).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddc58fb04a1312a63ff4142fbb04fc0
https://doi.org/10.1021/acs.bioconjchem.8b00894
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9
Capillary electrophoresis study of systemin peptides spreading in tomato plant
Autor: Michal Dobkowski, Ewelina Backtrog, Piotr Rekowski, Jarosław Ruczyński, Piotr Mucha
Publikováno v: ELECTROPHORESIS. 40:336-342
Systemin (Sys) is an 18-aa plant peptide hormone involved in the regulation of plant's defensive response. Sys is considered as a fast-spreading systemic wound signal. We developed a simple and rapid CE method to monitor the spreading of Sys peptides
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b02e9a9fc6a8774c9e10240474a50a1
https://doi.org/10.1002/elps.201800206
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