Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jarosław Ruczyński"'
Autor:
Piotr Mucha, Małgorzata Pieszko, Irena Bylińska, Wiesław Wiczk, Jarosław Ruczyński, Katarzyna Prochera, Piotr Rekowski
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 570 (2024)
Nucleopeptides (NPs) represent synthetic polymers created by attaching nucleobases to the side chains of amino acid residues within peptides. These compounds amalgamate the characteristics of peptides and nucleic acids, showcasing a unique ability to
Externí odkaz:
https://doaj.org/article/89d9b7d893a14d4aa80d008974ef2add
Autor:
Agnieszka Polak, Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Katarzyna Prochera, Oliwia Bujak, Piotr Mucha, Piotr Rekowski, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1463 (2024)
Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays a key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations of the PCSK9 gene lead to a reduced number of surface LDL receptors by
Externí odkaz:
https://doaj.org/article/05ecf1f8957741d68f801333c6bdec69
Autor:
Piotr Sass, Paweł Sosnowski, Justyna Podolak-Popinigis, Bartosz Górnikiewicz, Jolanta Kamińska, Milena Deptuła, Ewa Nowicka, Anna Wardowska, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski, Natalia Filipowicz, Alina Mieczkowska, Grażyna Peszyńska-Sularz, Łukasz Janus, Piotr Skowron, Artur Czupryn, Piotr Mucha, Arkadiusz Piotrowski, Sylwia Rodziewicz-Motowidło, Michał Pikuła, Paweł Sachadyn
Publikováno v:
EBioMedicine, Vol 46, Iss , Pp 317-329 (2019)
Background: Most studies on regenerative medicine focus on cell-based therapies and transplantations. Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensively investigated in regenerative researc
Externí odkaz:
https://doaj.org/article/8eda6354883a47edbc0359b12e94f43b
Autor:
Jarosław Ruczyński, Izabela Rusiecka, Katarzyna Turecka, Agnieszka Kozłowska, Magdalena Alenowicz, Iwona Gągało, Anna Kawiak, Piotr Rekowski, Krzysztof Waleron, Ivan Kocić
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract In the presented study, transportan 10 (TP10), an amphipathic cell penetrating peptide (CPP) with high translocation activity, was conjugated with vancomycin (Van), which is known for poor access to the intracellular bacteria and the brain.
Externí odkaz:
https://doaj.org/article/6ab41cdc1a11452badeea81901679a26
Autor:
Jarosław Ruczyński, Brygida Parfianowicz, Piotr Mucha, Katarzyna Wiśniewska, Lidia Piechowicz, Piotr Rekowski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8269 (2022)
Mastoparan (MP) is an antimicrobial cationic tetradecapeptide with the primary structure INLKALAALAKKIL-NH2. This amphiphilic α-helical peptide was originally isolated from the venom of the wasp Paravespula lewisii. MP shows a variety of biological
Externí odkaz:
https://doaj.org/article/d954e315738b40a68fd08887766f0877
Publikováno v:
Cells, Vol 11, Iss 10, p 1638 (2022)
Arginine-rich cell-penetrating peptides (RRCPPs) exhibit intrinsic neuroprotective effects on neurons injured by acute ischemic stroke. Conformational properties, interaction, and the ability to penetrate the neural membrane are critical for the neur
Externí odkaz:
https://doaj.org/article/dd0e86fc129941b1bf2fd09994ed27eb
Autor:
Jarosław Mazuryk, Izabela Puchalska, Kamil Koziński, Magdalena J. Ślusarz, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski, Rafał Płatek, Marta Barbara Wiśniewska, Arkadiusz Piotrowski, Łukasz Janus, Piotr M. Skowron, Michał Pikuła, Paweł Sachadyn, Sylwia Rodziewicz-Motowidło, Artur Czupryn, Piotr Mucha
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6086 (2021)
Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the
Externí odkaz:
https://doaj.org/article/ef6c429839b2495d98df9ab895d53e39
Autor:
Grażyna Peszyńska-Sularz, Łukasz Janus, Artur Czupryn, Sylwia Rodziewicz-Motowidło, Piotr M. Skowron, Paweł Sachadyn, Piotr Rogujski, Alina Mieczkowska, Natalia Filipowicz, Bartosz Górnikiewicz, Paweł Sosnowski, Michał Pikuła, Anna Wardowska, Ewa Nowicka, Piotr Rekowski, Arkadiusz Piotrowski, Jolanta Kamińska, Milena Deptuła, Piotr Mucha, Piotr Sass, Justyna Podolak-Popinigis, Jarosław Ruczyński
Publikováno v:
EBioMedicine
Background Most studies on regenerative medicine focus on cell-based therapies and transplantations. Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensively investigated in regenerative research
Autor:
Ewelina Backtrog, Piotr Rekowski, Izabela Rusiecka, Jarosław Ruczyński, Agnieszka Kozłowska, Piotr Mucha, Ivan Kocić
Publikováno v:
Bioconjugate Chemistry. 30:760-774
Parkinson's disease (PD) is a common progressive neurodegenerative disorder for which the current treatment is not fully satisfactory. One of the major drawbacks of current PD therapy is poor penetration of drugs across the blood-brain barrier (BBB).
Publikováno v:
ELECTROPHORESIS. 40:336-342
Systemin (Sys) is an 18-aa plant peptide hormone involved in the regulation of plant's defensive response. Sys is considered as a fast-spreading systemic wound signal. We developed a simple and rapid CE method to monitor the spreading of Sys peptides