Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jarosław M. Cieśla"'
Autor:
Patrycja Wińska, Łukasz Widło, Elżbieta Senkara, Mirosława Koronkiewicz, Jarosław M. Cieśla, Alicja Krzyśko, Katarzyna Skierka, Joanna Cieśla
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Thymidylate synthase (TS), dihydrofolate reductase (DHFR), and serine hydroxymethyltransferase (SHMT) constitute the thymidylate synthesis cycle providing thymidylate for DNA synthesis and repair. Our previous studies indicated that TS and DHFR are t
Externí odkaz:
https://doaj.org/article/7996ee4219e6416abfab7151045eb4d9
Autor:
Mirosława Koronkiewicz, Alicja Krzyśko, Maria Bretner, Jarosław M. Cieśla, Patrycja Wińska, Joanna Cieśla, Katarzyna Skierka, Łukasz Widło
Publikováno v:
Anticancer Research. 39:3531-3542
Background/aim Recently, we demonstrated the ability of inhibitors of protein kinase 2 (casein kinase II; CK2) to enhance the efficacy of 5-fluorouracil, a thymidylate synthase (TYMS)-directed drug for anticancer treatment. The present study aimed to
Autor:
Aditi U. Gurkar, Małgorzata Nowak, Jolanta Czerwińska, Dorota Dziuban-Lech, Elżbieta Speina, Jarosław M. Cieśla, Barbara Tudek, Anna Barańczyk-Kuźma, Konrad Kosicki, Daria Kołata, Ryszard Olinski, Hillary L. Shane, Lora H. Rigatti, Patrycja Wojtczak, Małgorzata Bednarek, Beata Gajewska, Matthew J. Yousefzadeh, Ewelina Zarakowska, Daniel Gackowski, Siobhán Q. Gregg, Andria Rasile Robinson, Sara J. McGowan, Laura J. Niedernhofer
Publikováno v:
Free Radical Biology and Medicine. 124:79-96
Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks. Here, we used
Autor:
Jarosław M. Cieśla, Jadwiga Szczegielniak, Robert Gromadka, Krzysztof Olszak, Lidia Polkowska-Kowalczyk, Grażyna Muszyńska
Publikováno v:
Plant Growth Regulation. 84:303-315
Calcium-dependent protein kinases (CDPKs or CPKs), unique to plants and some protists, are involved in growth and developmental processes as well as in defence against diverse environmental stresses. CDPKs are encoded by multi-gene families. Despite
Autor:
Andrea Dardis, Paweł Włodarski, Paolo Peruzzo, Roksana Iwanicka-Nowicka, Jarosław M. Cieśla, Barbara Żyżyńska-Granica, Anna Fogtman, Małgorzata Bednarska-Makaruk, Marta Koblowska, Katarzyna Hetmańczyk-Sawicka, Agnieszka Ługowska, Mirella Filocamo
Publikováno v:
Neurogenetics. 21(2)
Changes in gene expression profiles were investigated in 23 patients with Niemann-Pick C1 disease (NPC). cDNA expression microarrays with subsequent validation by qRT-PCR were used. Comparison of NPC to control samples revealed upregulation of genes
Autor:
Lidia Borkiewicz, Jadwiga Szczegielniak, Maciej Jończyk, Lidia Polkowska-Kowalczyk, Paweł Sowiński, Radosław Jaźwiec, Katarzyna Patrycja Szymańska, Wojciech Rymaszewski, Grażyna Muszyńska, Jarosław M. Cieśla
Publikováno v:
Physiologia plantarumReferences. 168(1)
In plants, CALCIUM-DEPENDENT PROTEIN KINASES (CDPKs/CPKs) are involved in calcium signaling in response to endogenous and environmental stimuli. Here, we report that ZmCPK11, one of maize CDPKs, participates in salt stress response and tolerance. Sal
Autor:
Joanna Żylińska, Roman Krzysztof Górecki, Jarosław M. Cieśla, Krzysztof Gulewicz, Jacek Bardowski, Tamara Aleksandrzak-Piekarczyk, Weronika Puzia
Publikováno v:
MicrobiologyOpen
The aim of this study was to characterize and compare selected Lactobacillus strains originating from different environments (cow milk and hen feces) with respect to their applicative potential to colonize gastrointestinal track of chickens before ha
Autor:
Ryszard Olinski, Elżbieta Speina, Daniel Gackowski, Beata Janowska, Maja Swoboda, Barbara Tudek, Justyna Janik, Jarosław M. Cieśla, Janusz Kowalewski
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :21-31
Decreased repair of oxidative DNA damage is a risk factor for developing certain human malignancies. We have previously found that the capacity of 8-oxo-7,8-dihydroguanine repair was lower in leukocytes of NSCLC patients than in controls. To explain
Publikováno v:
Sensors; Volume 7; Issue 8; Pages: 1462-1479
Sensors, Vol 7, Iss 8, Pp 1462-1479 (2007)
Sensors, Vol 7, Iss 8, Pp 1462-1479 (2007)
The chemically modified piezoelectrodes were utilized to develop relativelycheap and easy to use biosensor for determination of genetically modified Roundup Readysoybean (RR soybean). The biosensor relies on the immobilization onto goldpiezoelectrode
Autor:
Barbara Tudek, Zygmunt Kazimierczuk, Maria-Anna Gra̧ziewicz, Elżbieta Speina, Jarosław M. Cieśla, Jacques Laval
Publikováno v:
Acta Biochimica Polonica. 52:167-178
DNA base analogs, 2,4,5,6-substituted pyrimidines and 2,6-substituted purines were tested as potential inhibitors of E. coli Fpg protein (formamidopyrimidine -DNA glycosylase). Three of the seventeen compounds tested revealed inhibitory properties. 2