Výsledky vyhledávání - "Jaromir Vlach"

Akademický článek

Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases

Autor: Thomas Clarke, Pan Du, Satyendra Kumar, Shinji L. Okitsu, Mark Schuette, Qi An, Jinyang Zhang, Evgeni Tzvetkov, Mark A. Jensen, Timothy B. Niewold, Elise M. N. Ferre, Julie Nardone, Michail S. Lionakis, Jaromir Vlach, Julie DeMartino, Andrew T. Bender

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Autoimmune diseases vary in the magnitude and diversity of autoantibody profiles, and these differences may be a consequence of different types of breaks in tolerance. Here, we compared the disparate autoimmune diseases autoimmune polyendocrinopathy�

Externí odkaz: https://doaj.org/article/e823a778e94642ba916ed495ae37f622

Zobrazit plný text záznamu

Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity

Autor: Melinda Przetak, Aditee Deshpande, Simone C. Zimmerli, Noune Tahmassian Morse, Evgeni Tzvetkov, Albertina Pereira, Sonja Reissig, Robert L. Walsky, Shinji L. Okitsu, Philipp Haselmayer, Djordje Musil, Sherer Brian A, Jaromir Vlach, Theresa L. Johnson, Andrew Bender

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 376:397-409

Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production, which is normally a protective host response. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963e63bf34625b4b6f50f0a262d440b1
https://doi.org/10.1124/jpet.120.000275

Zobrazit plný text záznamu

TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation

Autor: Shinji L. Okitsu, Timothy B. Niewold, Mark A. Jensen, Yin Wu, Melinda Przetak, Siddha Kasar, Jaromir Vlach, Evgeni Tzvetkov, Albertina Pereira, Andrew Bender

Publikováno v: ImmunoHorizons. 4:93-107

TLR7 and TLR8 are pattern recognition receptors that reside in the endosome and are activated by ssRNA molecules. TLR7 and TLR8 are normally part of the antiviral defense response, but they have also been implicated as drivers of autoimmune diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ebe4936e77adbeff8339be868dcf1e
https://doi.org/10.4049/immunohorizons.2000002

Zobrazit plný text záznamu

O37 M5049, a novel potent and selective inhibitor of toll-like receptors 7 and 8 (TLR 7/8)

Autor: Shinji L. Okitsu, Sherer Brian A, Philipp Haselmayer, Evgeni Tzvetkov, Andrew Bender, Melinda Przetak, Albertina Pereira, Noune Tahmassian Morse, Jaromir Vlach, Sonja Reissig

Publikováno v: Oral presentations.

Background TLR 7/8 are transmembrane receptors that recognize single-stranded RNA. In humans, TLR7 is mainly expressed in B cells and plasmacytoid dendritic cells and its activation stimulates antibody production and secretion of cytokines including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08c3e660bb1f65098a930a36dba4857f
https://doi.org/10.1136/lupus-2020-eurolupus.48

Zobrazit plný text záznamu

Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment

Autor: Michael Gobert, Christophe Caux, Nadège Goutagny, Amélien Sanlaville, Isabelle Le Mercier, Jacqueline Marvel, Isabelle Durand, Nathalie Bendriss-Vermare, Isabelle Puisieux, Dominique Poujol, Jaromir Vlach, Isabelle Treilleux, Vanja Sisirak, Jean-Yves Blay, Bertrand Dubois

Publikováno v: Cancer Research. 73:4629-4640

Plasmacytoid dendritic cells (pDC) are key regulators of antiviral immunity. In previous studies, we reported that pDC-infiltrating human primary breast tumors represent an independent prognostic factor associated with poor outcome. To understand thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89910fd46575827d86c28e5d63fd4748
https://doi.org/10.1158/0008-5472.can-12-3058

Zobrazit plný text záznamu

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

Publikováno v: Journal of medicinal chemistry. 59(17)

Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcdde8057c6d45e0f5c5a8697064288
https://pubmed.ncbi.nlm.nih.gov/27513093

Zobrazit plný text záznamu

Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs

Autor: Christine Ménétrier-Caux, Ivan Perrot, Anne-Claire Doffin, Christophe Caux, Jaromir Vlach, Massimo Tommasino, Uzma Hasan, Giorgio Trinchieri

Publikováno v: Proceedings of the National Academy of Sciences. 104:8047-8052

TRIF is an adaptor protein associated with the signaling by Toll-like receptor (TLR)3 and TLR4 for the induction of type I IFNs. Here, we demonstrate a mechanism by which TLR signaling controls cell proliferation and survival. We show that TLR3 and T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadf4101657effda3d1c023675ffa690
https://doi.org/10.1073/pnas.0700664104

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání