Výsledky vyhledávání - "Jaromír Pastorek"

Akademický článek

Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

Autor: Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek

Publikováno v: Cancer & Metabolism, Vol 10, Iss 1, Pp 1-16 (2022)

Abstract Background Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be successful. This knowledg

Externí odkaz: https://doaj.org/article/e6274b37750142d7bf1bd22aaf2132f5

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The presence of P-glycoprotein in L1210 cells directly induces down-regulation of cell surface saccharide targets of concanavalin A

Autor: Zdena, Sulová, Peter, Ditte, Tatiana, Kurucová, Eva, Poláková, Kristína, Rogozanová, Lenka, Gibalová, Mário, Seres, Lucia, Skvarková, Ján, Sedlák, Jaromír, Pastorek, Albert, Breier

Publikováno v: Anticancer research. 30(9)

Overexpression of P-glycoprotein (P-gp), a plasma membrane drug transporter (ABCB1, a member of the ABC transporter family), is the most prevalent cause of multidrug resistance in cancer tissues. Lectin concanavalin A (ConA) induces massive cell deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a5aafd5369fa50bf9943a9f2696629e
https://pubmed.ncbi.nlm.nih.gov/20944151

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Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX

Autor: Miriam, Zat'ovicová, Kvetoslava, Tarábková, Eliska, Svastová, Adriana, Gibadulinová, Vojtech, Mucha, Lýdia, Jakubícková, Zuzana, Biesová, Monika, Rafajová, Marta, Ortova Gut, Seppo, Parkkila, Anna Kaisa, Parkkila, Abdul, Waheed, Willam S, Sly, Ivan, Horak, Jaromír, Pastorek, Silvia, Pastoreková

Publikováno v: Journal of immunological methods. 282(1-2)

Transmembrane carbonic anhydrase IX (CA IX) is frequently expressed in human tumours in response to hypoxia and may serve as a tumour marker and therapeutic target. So far, only a single monoclonal antibody (MAb) M75 with an epitope in the N-terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccbf52e346f550dae5d12b27130a650b
https://pubmed.ncbi.nlm.nih.gov/14604546

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Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma

Autor: Adrián, Chrastina, Jan, Závada, Seppo, Parkkila, Stefan, Kaluz, Milota, Kaluzová, Július, Rajcáni, Jaromír, Pastorek, Silvia, Pastoreková

Publikováno v: International journal of cancer. 105(6)

Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdefeb1d2c127682c18550278ba24ba6
https://pubmed.ncbi.nlm.nih.gov/12767076

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Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase

Autor: Stefan, Kaluz, Milota, Kaluzová, Adrian, Chrastina, Peggy L, Olive, Silvia, Pastoreková, Jaromír, Pastorek, Michael I, Lerman, Eric J, Stanbridge

Publikováno v: Cancer research. 62(15)

Transcription of the gene coding for the tumor-associated antigen MN/carbonic anhydrase IX (CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1). Previous studies identified CAIX expression in areas adjacent to hypoxic regions in solid tumors and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3e47807989554d8f24a04b828e4c67b
https://pubmed.ncbi.nlm.nih.gov/12154057

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Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2

Autor: Mária, Bartosová, Seppo, Parkkila, Kamil, Pohlodek, Tuomo J, Karttunen, Stefan, Galbavý, Vojtech, Mucha, Adrian L, Harris, Jaromír, Pastorek, Silvia, Pastoreková

Publikováno v: The Journal of pathology. 197(3)

CA IX is a tumour-associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aa8478dd52a244105bb7fabf6f090b0
https://pubmed.ncbi.nlm.nih.gov/12115877

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Characterization of the MN/CA 9 promoter proximal region: a role for specificity protein (SP) and activator protein 1 (AP1) factors

Autor: Milota KALUZOVÁ, Silvia PASTOREKOVÁ, Eliska SVASTOVÁ, Jaromír PASTOREK, Eric J. STANBRIDGE, Stefan KALUZ

MN/CA IX (MN) is a tumour-associated isoenzyme of the carbonic anhydrase family. Previous deletion analysis of the MN promoter established that protected regions (PRs) 1 and 2 are crucial for its transcriptional activity. Computer-assisted searching

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bf8e1fb263ef8d3c06d717a3b54389
https://europepmc.org/articles/PMC1222189/

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Akademický článek

Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.

Autor: Heini Kallio, Martti Tolvanen, Janne Jänis, Pei-wen Pan, Eeva Laurila, Anne Kallioniemi, Sami Kilpinen, Vilppu J Tuominen, Jorma Isola, Jarkko Valjakka, Silvia Pastorekova, Jaromir Pastorek, Seppo Parkkila

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27152 (2011)

Our previous microarray study showed that the non-specific cytotoxic cell receptor protein 1 (Nccrp1) transcript is significantly upregulated in the gastric mucosa of carbonic anhydrase IX (CA IX)-deficient (Car9(-/-)) mice. In this paper, we aimed t

Externí odkaz: https://doaj.org/article/bae20915bfed4d848993aed335d49468

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