Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jarno G. Sikkens"'
Autor:
Anna Joëlle Ruff, Ulrich Schwaneberg, Mehdi D. Davari, Jarno G. Sikkens, Hannah U. C. Brass, Stefanie Brands, Andreas Sebastian Klein, Jörg Pietruszka
Publikováno v:
Catalysis Science & Technology. 11:2805-2815
Prodigiosin ligase PigC catalyses the final condensation step in the prodigiosin biosynthesis of Serratia marcescens, in which two pyrrolic precursor molecules are fused linearly to form tripyrrolic red prodiginines. Prodiginine compounds attracted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ba94f81dfb273cd9fb5078ec0f7040
https://doi.org/10.1039/d0cy02297g
https://doi.org/10.1039/d0cy02297g
Autor:
Stefanie Brands, Anna Joëlle Ruff, Ulrich Schwaneberg, Hannah U. C. Brass, Jarno G. Sikkens, Andreas Sebastian Klein, Mehdi D. Davari, Jörg Pietruszka
Publikováno v:
Chemical communications 57(21), 2681-2684 (2021). doi:10.1039/D0CC08226K
Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b952fe0f46c3c05393c8c145573311dc
https://hdl.handle.net/2128/29752
https://hdl.handle.net/2128/29752
