Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits

Autor: Christian J. F. Bertens, Ralph J. S. van Mechelen, Tos T. J. M. Berendschot, Marlies Gijs, Jarno E. J. Wolters, Theo G. M. F. Gorgels, Rudy M. M. A. Nuijts, Henny J. M. Beckers

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on

Externí odkaz: https://doaj.org/article/dc4b4f9e4dab455facc220f13d94f395

Wound Healing Response After Bleb-Forming Glaucoma Surgery With a SIBS Microshunt in Rabbits

Autor: Ralph J S, van Mechelen, Jarno E J, Wolters, Marjolein, Herfs, Christian J F, Bertens, Marion, Gijbels, Leonard, Pinchuk, Theo G M F, Gorgels, Henny J M, Beckers

Publikováno v: Translational Vision Science and Technology, 11(8):29. Association for Research in Vision and Ophthalmology Inc.
Translational Vision Science & Technology, 11(8):29. Association for Research in Vision and Ophthalmology

Purpose: The PreserFlo MicroShunt is an innovative implant for the surgical treatment of glaucoma. Although usually effective, surgeries can still fail due to fibrosis. This study was conducted to gain insight into the histological aspects of the fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd343fade5ec587435a8f7c21765fb3
https://doi.org/10.1167/tvst.11.8.29

Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression

Autor: J.C.S. (Jos) Kleinjans, E. Smit, T. van den Beucken, Jarno E J Wolters, Yannick Schrooders, Florian Caiment

Publikováno v: Archives of Toxicology, 94(10), 3463-3473. Springer
Archives of Toxicology

Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2264e895e90bf5edc397ca999ca4be7a
https://cris.maastrichtuniversity.nl/en/publications/9ab1a694-19a2-48d7-b579-6a5b1d5c985f

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

Autor: Jarno E J Wolters, Jonas Grossmann, Simone G. J. van Breda, Claudia Fortes, Jos C. S. Kleinjans, Florian Caiment

Publikováno v: Toxicology Letters, 289, 1-13. Elsevier Ireland Ltd
Toxicology Letters, 289

We performed a multiple ‘omics study by integrating data on epigenomic, transcriptomic, and proteomic perturbations associated with mitochondrial dysfunction in primary human hepatocytes caused by the liver toxicant valproic acid (VPA), to deeper u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eb860356bb901174816abf436f44da
https://doi.org/10.1016/j.toxlet.2018.02.026

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

Autor: Jarno E J Wolters, Simone G. J. van Breda, Sandra M.H. Claessen, Theo M. de Kok, Jos C. S. Kleinjans, Florian Caiment

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, 30(10), 1847-1854. American Chemical Society

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The aim of this study is to further invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db21788e6f9a4d2f3ad60b61d0489b
http://europepmc.org/articles/PMC5645762