Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jarmila Mlcouskova"'
Autor:
Karina Zadorozhny, Vincenzo Sannino, Ondrej Beláň, Jarmila Mlčoušková, Mário Špírek, Vincenzo Costanzo, Lumír Krejčí
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 333-340 (2017)
Summary: Fanconi anemia (FA) is a genetic disorder characterized by a defect in DNA interstrand crosslink (ICL) repair, chromosomal instability, and a predisposition to cancer. Recently, two RAD51 mutations were reported to cause an FA-like phenotype
Externí odkaz:
https://doaj.org/article/97283005af86473c93c2b628f9cbc703
Autor:
Veronika Altmannova, Mario Spirek, Lucija Orlic, Atis Jēkabsons, Tereza Clarence, Adrian Henggeler, Jarmila Mlcouskova, Raphaël A.G. Chaleil, Joao Matos, Lumir Krejci
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105439- (2022)
Summary: During meiosis, programmed DNA double-strand breaks (DSBs) are repaired by homologous recombination. DMC1, a conserved recombinase, plays a central role in this process. DMC1 promotes DNA strand exchange between homologous chromosomes, thus
Externí odkaz:
https://doaj.org/article/b1ba76f4797844b890a9b02c8b817ef3
Autor:
Lumir Krejci, Mário Špírek, Fletcher E. Bain, Daniel Nemecek, Sarah R. Hengel, Jana Prochazkova, Liping Yu, Brandon G Koch, Maria Spies, Jarmila Mlcouskova, Barbora Stefanovie, Fedor Nikulenkov
Publikováno v:
Nucleic Acids Research
The proper repair of deleterious DNA lesions such as double strand breaks prevents genomic instability and carcinogenesis. In yeast, the Rad52 protein mediates DSB repair via homologous recombination. In mammalian cells, despite the presence of the R
Autor:
Jiri Novacek, Mihály Kovács, Lumir Krejci, Máté Gyimesi, Jarmila Mlcouskova, Eszter Molnár, Ondrej Beláň, Mário Špírek, Gábor M. Harami
Publikováno v:
Nucleic Acids Research
Formation of RAD51 filaments on single-stranded DNA is an essential event during homologous recombination, which is required for homology search, strand exchange and protection of replication forks. Formation of nucleoprotein filaments (NF) is requir
Autor:
Jun Ho, Ko, Mi Young, Son, Qing, Zhou, Lucia, Molnarova, Lambert, Song, Jarmila, Mlcouskova, Atis, Jekabsons, Cristina, Montagna, Lumir, Krejci, Paul, Hasty
Publikováno v:
Cell reports
SUMMARY DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error
Autor:
Jarmila Mlcouskova, Paul Hasty, Cristina Montagna, Atis Jekabsons, Lumir Krejci, Lucia Molnarova, Jun Ho Ko, Mi Young Son, Lambert Song, Qing Zhou
Publikováno v:
Cell Reports. 33:108543
DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone l
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 17:891-898
Carboplatin, an analogue of "classical" cis-diamminedichloridoplatinum(II) (cisplatin), is a widely used second-generation platinum anticancer drug. Cytotoxicity of cisplatin and carboplatin is mediated by platinum-DNA adducts. Markedly higher concen
Publikováno v:
DNA repair. 30
The RECQ4 protein belongs to the RecQ helicase family, which plays crucial roles in genome maintenance. Mutations in the RECQ4 gene are associated with three insidious hereditary disorders: Rothmund-Thomson, Baller-Gerold, and RAPADILINO syndromes. T
Autor:
Jaroslav Malina, Jana Kasparkova, Vojtech Novohradsky, Jarmila Mlcouskova, Viktor Brabec, Seiji Komeda
Publikováno v:
Biochimica et biophysica acta. 1820(10)
Background The design of anticancer metallodrugs is currently focused on platinum complexes which form on DNA major adducts that cannot readily be removed by DNA repair systems. Hence, antitumor azolato-bridged dinuclear PtII complexes, such as [{cis
Publikováno v:
Journal of inorganic biochemistry. 114
Design of new antitumor Pt drugs is currently also focused on those new Pt complexes which form on DNA major adducts that can hardly be removed by DNA repair systems. An attempt of this kind has already been done by designing and synthesizing new ant