Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jarmila Kralova"'
Autor:
Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionAutoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One of the well-established animal models of this group of disorders is the mouse strain Pstpip2cmo. In this
Externí odkaz:
https://doaj.org/article/26500fa665154620ac4ba6875d226417
Autor:
Matej Fabisik, Jolana Tureckova, Nataliia Pavliuchenko, Jarmila Kralova, Jana Balounova, Kristina Vicikova, Tereza Skopcova, Frantisek Spoutil, Jana Pokorna, Pavla Angelisova, Bernard Malissen, Jan Prochazka, Radislav Sedlacek, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved
Externí odkaz:
https://doaj.org/article/cffacaa3019449b9b6eb6f98e9a28e44
Autor:
Irena Moserova, Jarmila Kralova
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32972 (2012)
We have analyzed the molecular mechanisms of photoinduced cell death using porphyrins with similar structure differing only in the position of the ethylene glycol (EG) chain on the phenyl ring. Meta- and para-positioned EG chains targeted porphyrins
Externí odkaz:
https://doaj.org/article/282e11c7158049349df680560bff8fdf
Autor:
Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Nemanja Stanojevic, Ido Amit, Uri Alon, Valery Krizhanovsky
The accumulation of senescent cells promotes aging, but a molecular mechanism that senescent cells use to evade immune clearance and accumulate remains to be elucidated. Here, we report that p16-positive senescent cells upregulate the immune checkpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4e2f7227e83507ed7a204748568db2
https://doi.org/10.1101/2023.01.30.524522
https://doi.org/10.1101/2023.01.30.524522
Autor:
Robert Kaplánek, Vladimír Král, Pavel Martásek, Tomáš Bříza, Martin Havlík, Ivan Mikula, Jarmila Kralova, Zdeněk Kejík, Milan Jakubek
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2295-2306
Modifications of DNA cytosine bases and histone posttranslational modifications play key roles in the control of gene expression and specification of cell states. Such modifications affect many important biological processes and changes to these impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1087104ecb19e1767daa27916fc7de06
https://doi.org/10.1016/j.bmc.2017.01.011
https://doi.org/10.1016/j.bmc.2017.01.011
Autor:
Lucie Krčová, Veronika Talianová, Bohumil Dolenský, Martin Havlík, Vladimír Král, Pavel Martásek, Jarmila Kralova, Tomáš Bříza
Publikováno v:
Bioorganic chemistry. 94
The fluorescent probes based on Troger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3212b5ca20cf12ac6bc32183a7344b1d
https://pubmed.ncbi.nlm.nih.gov/31810756
https://pubmed.ncbi.nlm.nih.gov/31810756
Publikováno v:
The Journal of Immunology. 206:97.03-97.03
PSTPIP2 is an adaptor protein, which binds multiple regulators of neutrophil signaling to suppress inflammation. The compete loss of PSTPIP2 protein in the mouse strain Pstpip2cmo results in the development of autoinflammatory disease chronic multifo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e169faa5a2ceb042c1c30a256d78117c
https://doi.org/10.4049/jimmunol.206.supp.97.03
https://doi.org/10.4049/jimmunol.206.supp.97.03
Autor:
Robert Kaplánek, Vladimír Král, Pavel Martásek, Jarmila Kralova, Tomáš Bříza, Bohumil Dolenský, Martin Havlík, Ivan Mikula, Zdeněk Kejík
Publikováno v:
Dyes and Pigments. 134:212-218
Symmetric Troger’s base derivatives with quinolinium substitution, 7 and 8, were prepared, and their structures were confirmed by 1H and 13C NMR, 2D NMR and NOE NMR techniques and elemental analysis. These compounds were studied as specific ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76903ce4aec94753f1c05bf1676334ec
https://doi.org/10.1016/j.dyepig.2016.07.002
https://doi.org/10.1016/j.dyepig.2016.07.002
Autor:
Jarmila Kralova, Vladimír Král, Pavel Martásek, Zdeněk Kejík, Milan Jakubek, Ivan Mikula, Robert Kaplánek
Publikováno v:
Future medicinal chemistry. 10(9)
In the last decade, epigenetic drugs (such as inhibitors of DNA methyltransferases and histone deacetylases) have been intensively used for cancer treatment. Their applications have shown high anticancer effectivity and tolerable side effects. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca71061e4cfd055e707ff6dcd48c595a
https://pubmed.ncbi.nlm.nih.gov/29676175
https://pubmed.ncbi.nlm.nih.gov/29676175
Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders
Autor:
Petr Bartunek, Bohumil Dolensky, Ivan Novotný, Zdeňka Rottnerová, Michal Dušek, Michal Jurášek, Vladimír Král, Jarmila Kralova, Pavel Drašar, Michal Kahle, Lucie Krčová
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The monitoring of intracellular cholesterol homeostasis and trafficking is of great importance because their imbalance leads to many pathologies. Reliable tools for cholesterol detection are in demand. This study presents the design and synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df46abdf38bfc35adfe92f0e493733
https://doi.org/10.1101/267948
https://doi.org/10.1101/267948