Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jarmila Kralova"'
Autor:
Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionAutoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One of the well-established animal models of this group of disorders is the mouse strain Pstpip2cmo. In this
Externí odkaz:
https://doaj.org/article/26500fa665154620ac4ba6875d226417
Autor:
Matej Fabisik, Jolana Tureckova, Nataliia Pavliuchenko, Jarmila Kralova, Jana Balounova, Kristina Vicikova, Tereza Skopcova, Frantisek Spoutil, Jana Pokorna, Pavla Angelisova, Bernard Malissen, Jan Prochazka, Radislav Sedlacek, Tomas Brdicka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved
Externí odkaz:
https://doaj.org/article/cffacaa3019449b9b6eb6f98e9a28e44
Autor:
Radovan Krejcir, Lucie Krcova, Pavlina Zatloukalova, Tomas Briza, Philip J. Coates, Martin Sterba, Petr Muller, Jarmila Kralova, Pavel Martasek, Vladimir Kral, Borivoj Vojtesek
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4208 (2019)
Cancer cells preferentially utilize glycolysis for ATP production even in aerobic conditions (the Warburg effect) and adapt mitochondrial processes to their specific needs. Recent studies indicate that altered mitochondrial activities in cancer repre
Externí odkaz:
https://doaj.org/article/a4061855bf9147c78bc91e93094358ca
Autor:
Irena Moserova, Jarmila Kralova
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32972 (2012)
We have analyzed the molecular mechanisms of photoinduced cell death using porphyrins with similar structure differing only in the position of the ethylene glycol (EG) chain on the phenyl ring. Meta- and para-positioned EG chains targeted porphyrins
Externí odkaz:
https://doaj.org/article/282e11c7158049349df680560bff8fdf
Autor:
Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Nemanja Stanojevic, Ido Amit, Uri Alon, Valery Krizhanovsky
The accumulation of senescent cells promotes aging, but a molecular mechanism that senescent cells use to evade immune clearance and accumulate remains to be elucidated. Here, we report that p16-positive senescent cells upregulate the immune checkpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4e2f7227e83507ed7a204748568db2
https://doi.org/10.1101/2023.01.30.524522
https://doi.org/10.1101/2023.01.30.524522
Publikováno v:
The Journal of Immunology. 206:97.03-97.03
PSTPIP2 is an adaptor protein, which binds multiple regulators of neutrophil signaling to suppress inflammation. The compete loss of PSTPIP2 protein in the mouse strain Pstpip2cmo results in the development of autoinflammatory disease chronic multifo
Autor:
Robert Kaplánek, Vladimír Král, Pavel Martásek, Tomáš Bříza, Martin Havlík, Ivan Mikula, Jarmila Kralova, Zdeněk Kejík, Milan Jakubek
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2295-2306
Modifications of DNA cytosine bases and histone posttranslational modifications play key roles in the control of gene expression and specification of cell states. Such modifications affect many important biological processes and changes to these impo
Autor:
Robert Kaplánek, Vladimír Král, Pavel Martásek, Jarmila Kralova, Tomáš Bříza, Bohumil Dolenský, Martin Havlík, Ivan Mikula, Zdeněk Kejík
Publikováno v:
Dyes and Pigments. 134:212-218
Symmetric Troger’s base derivatives with quinolinium substitution, 7 and 8, were prepared, and their structures were confirmed by 1H and 13C NMR, 2D NMR and NOE NMR techniques and elemental analysis. These compounds were studied as specific ligands
Autor:
Lucie Krčová, Veronika Talianová, Bohumil Dolenský, Martin Havlík, Vladimír Král, Pavel Martásek, Jarmila Kralova, Tomáš Bříza
Publikováno v:
Bioorganic chemistry. 94
The fluorescent probes based on Troger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four dif
Autor:
Jarmila Kralova, Vladimír Král, Pavel Martásek, Zdeněk Kejík, Milan Jakubek, Ivan Mikula, Robert Kaplánek
Publikováno v:
Future medicinal chemistry. 10(9)
In the last decade, epigenetic drugs (such as inhibitors of DNA methyltransferases and histone deacetylases) have been intensively used for cancer treatment. Their applications have shown high anticancer effectivity and tolerable side effects. Howeve