Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jarl E.S. Wikberg"'
Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking
Autor:
Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Publikováno v:
PeerJ, Vol 4, p e2322 (2016)
Alzheimer’s disease (AD) is a chronic neurodegenerative disease which leads to the gradual loss of neuronal cells. Several hypotheses for AD exists (e.g., cholinergic, amyloid, tau hypotheses, etc.). As per the cholinergic hypothesis, the deficienc
Externí odkaz:
https://doaj.org/article/e05fc79b75b54bce9a0f26ba671337ed
Autor:
Saw Simeon, Ola Spjuth, Maris Lapins, Sunanta Nabu, Nuttapat Anuwongcharoen, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Publikováno v:
PeerJ, Vol 4, p e1979 (2016)
Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel
Externí odkaz:
https://doaj.org/article/eabc57ca9294419c8c5caeff264fbe6f
Autor:
Jarl E.S. Wikberg, Edvards Liepinsh, Aleh Yahorau, Sviatlana Yahorava, Ilze Mutule, Adolf Gogoll, Felikss Mutulis
Publikováno v:
Molecules, Vol 13, Iss 8, Pp 1846-1863 (2008)
Abstract: Two molecules of indole derivative, e.g. indole-5-carboxylic acid, reacted with one molecule of thiol, e.g. 1,2-ethanedithiol, in the presence of trifluoroacetic acid to yield adducts such as 3-[2-(2-amino-5-carboxyphenyl)-1-(2-mercaptoethy
Externí odkaz:
https://doaj.org/article/0bb3a025ccd24693918b1512fa783c82
Autor:
Jarl E.S. Wikberg, Larisa Borisova-Jan, Aleh Yahorau, Sviatlana Yahorava, Jana Kreicberga, Ilze Mutule, Máté Erdélyi, Felikss Mutulis
Publikováno v:
Molecules, Vol 8, Iss 10, Pp 728-734 (2003)
Treatment of carboxylated Wang polymer attached to a 2-unsubstituted indole derivative with a trifluoroacetic acid based mixture resulted in a side reaction: p-hydroxybenzylation at the 2-position of the indole ring. The structure of the resulting N-
Externí odkaz:
https://doaj.org/article/af693dee24d54461bb1c4865d904d612
Autor:
Bashir Akhlaq Akhoon, Marta E. Alarcón-Riquelme, Lucas N. Alberca, Juan I. Alice, Nuttapat Anuwongcharoen, Kazim Yalcin Arga, Carolina L. Belllera, Vladimir P. Berishvili, Anshu Bhardwaj, Vijaya Lakshmi Bodiga, Sreedhar Bodiga, Michal Brylinski, Pedro Carmona-Sáez, Sohini Chakraborti, Vaishali Chaudhry, Lixia Chen, Mohane Selvaraj Coumar, Daniel Toro-Domínguez, Nikolas Dietis, Noelie Douanne, Dmitry Druzhilovskiy, K. Eurídice Juárez-Mercado, Christopher Fernández-Prada, Pankaj Gautam, Indira Ghosh, C. Gopi Mohan, Shozeb Haider, Li Hua, Jameel Iqbal, Nivya James, Bani Jolly, Prashant S. Kharkar, Se-Min Kim, Shivani Kumar, Suresh Kumar, Pawan Kumar, Lukasz Kurgan, Yu-Chen Lo, Edgar López-López, Janvhi S. Machhar, K. Manzoor, José L. Medina-Franco, Anu R. Melge, George Minadakis, Aida Minguez-Menendez, Makedonka Mitreva, Rubens L. Monte-Neto, Gurusamy Muneeswaran, Selvaraman Nagamani, Shantikumar V. Nair, Chanin Nantasenamat, G. Narahari Sastry, Amit Nargotra, Anastasia A. Nikitina, Alexey A. Orlov, Dmitry I. Osolodkin, Anastasis Oulas, Manoj Kumar Pal, Vladimir A. Palyulin, Ashma Pandya, Anurag Passi, Joan Pena, Chuleeporn Phanus-umporn, Douglas E.V. Pires, Vladimir Poroikov, Fernando D. Prieto-Martínez, Eugene V. Radchenko, Gayatri Ramakrishnan, K. Ramanathan, Bruce A. Rosa, Rosaleen Sahoo, Niteshkumar U. Sahu, Pemra Ozbek Sarica, Sailu Sarvagalla, Kyriaki Savva, María L. Sbaraglini, Nalini Schaduangrat, Onur Serçinoğlu, Chetan P. Shah, V. Shanthi, Tina Sharma, Kleitos Sokratous, George M. Spyrou, Narayanaswamy Srinivasan, Nagaya Sriwanichpoom, Li Sun, Safiulla Basha Syed, Alan Talevi, Harshita Tiwari, Jorge Z. Torres, Luiza G. Tunes, Beste Turanli, Rahul Tyagi, Chen Wang, Jarl E.S. Wikberg, Xuhua Xia, Tony Yuen, Margarita Zachariou, Neeha Zaidi, Samir Zaidi, Mone Zaidi, Alberta Zallone, Mengzhu Zheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d63436a8d351c25d0256d3c54b8fd0
https://doi.org/10.1016/b978-0-12-816125-8.09992-2
https://doi.org/10.1016/b978-0-12-816125-8.09992-2
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 78:143-149
Publikováno v:
Biochemical Pharmacology. 32:3171-3178
An improved method for the solubilization of the alpha1-adrenergic receptors in rat liver, utilizing digitonin, glycerol and sonication, is described. The yield of solubilized receptors was approximately 20%. The soluble receptors showed characterist
Autor:
Robert J. Lefkowitz, Jarl E.S. Wikberg
Publikováno v:
Life Sciences. 31:2899-2905
We provide direct evidence that alpha 2 -receptors in the guinea pig small intestine are localized prejunctionally in neurons of the Auerbach's plexus. The alpha 2 -agonist ligand [ 3 H]clonidine bound to a single saturable class of sites with a K d
Autor:
David L. Arendsen, John F. DeBernardis, L. M. Fredrik Leeb-Lundberg, Jarl E.S. Wikberg, Marty Winn, Kenneth E. J. Dickinson, Sarah L. Heald, Marc G. Caron, Robert J. Lefkowitz
Publikováno v:
Biochemical and Biophysical Research Communications. 115:946-951
A novel high affinity radioiodinated photoaffinity probe, 4-amino-6,7-dimethoxy-2[4-[5(3-[125I]iodo-4-azidophenyl)pentanoyl]-1- piperazinyl]-quinazoline, structurally related to the potent alpha 1-adrenergic antagonist prazosin, was developed and use
Publikováno v:
PEDS: Protein Engineering, Design & Selection; Jun2007, Vol. 20 Issue 6, p301-301, 1p