Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jarkko Ketolainen"'
Autor:
Tuomas Ervasti, Hannes Niinikoski, Eero Mäki-Lohiluoma, Heidi Leppinen, Jarkko Ketolainen, Ossi Korhonen, Satu Lakio
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 279 (2020)
Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a homogenous mixture. The scope of the current work was to explore if a continuous direct compressio
Externí odkaz:
https://doaj.org/article/bd55dad6bdd843cc915431d0af531343
Autor:
Sergey Savenkov, Alexander Priezzhev, Yevgen Oberemok, Ivan Kolomiets, Pertti Silfsten, Tuomas Ervasti, Jarkko Ketolainen, Kai-Erik Peiponen
Publikováno v:
Journal of Biomedical Photonics & Engineering, Vol 3, Iss 1 (2017)
In this paper, we measured the Mueller matrices of the samples with different porosity in the visible range (the wavelength of the input radiation ) for the observation angles from to . The samples under study were the tablets made of microcrystallin
Externí odkaz:
https://doaj.org/article/4a069eaf6daa4435bf614f01410db525
Autor:
Tuomas Kilpeläinen, Tuomas Ervasti, Emilia Uurasjärvi, Arto Koistinen, Jarkko Ketolainen, Ossi Korhonen, Katja Pajula
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 180:161-169
Many active pharmaceutical ingredients (API) in development suffer from low aqueous solubilities. Instead of the crystal form, the amorphous state can be used to improve the API's apparent solubility. However, the amorphous state has a higher Gibb's
Autor:
Jenna Lyytikäinen, Pawel Stasiak, Tomáš Kubelka, Tino Olenius, Ossi Korhonen, Jarkko Ketolainen, Tuomas Ervasti
Publikováno v:
International journal of pharmaceutics. 628
Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to evaluate technology transfer from batch-based direct compression of a commercial tablet formulation to conti
Publikováno v:
International Journal of Pharmaceutics. 639:122969
Autor:
Pirjo Tajarobi, Satu Lakio, Jarkko Ketolainen, Anisa Sulemanji, Magnus Fransson, Håkan Wikström, Kaisa M. Kyttä
Publikováno v:
Powder Technology. 376:187-198
The aim of the study was to compare continuous twin-screw granulation (TSG) with batch-wise high-shear granulation (HSG). Two different formulations containing either microcrystalline cellulose (MCC) and mannitol or MCC and dibasic calcium phosphate
Autor:
Atte Junnila, Håkan Wikström, Andrew Megarry, Aida Gholami, Foteini Papathanasiou, Andreas Blomberg, Jarkko Ketolainen, Pirjo Tajarobi
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 172
In early development, when active pharmaceutical ingredient (API) is in short supply, it would be beneficial to reduce the number of experiments by predicting a suitable L/S ratio before starting the product development. The aim of the study was to d
Autor:
Tipu Sultan, Xiaochi Xu, Enamul Hasan Rozin, Joona Sorjonen, Jarkko Ketolainen, Håkan Wikström, Luis Martin de Juan, Pirjo Tajarobi, Cetin Cetinkaya
Publikováno v:
International Journal of Pharmaceutics. 624:121993
Despite a well-established process understanding, quality issues for compressed oral solid dosage forms are frequently encountered during various drug product development and production stages. In the current work, a non-destructive contact ultrasoni
Autor:
Susanna Abrahmsén-Alami, Håkan Wikström, Anders Sparén, Ossi Korhonen, Magnus Fransson, Anssi-Pekka Karttunen, Mariagrazia Marucci, Jarkko Ketolainen, Staffan Folestad, Pirjo Tajarobi
Publikováno v:
European Journal of Pharmaceutical Sciences. 133:40-53
There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line, in relation
Autor:
Ivo Laidmäe, Kalle Kirsimäe, Jemina Vesala, Laura Viidik, Ossi Korhonen, Riikka Laitinen, Jyrki Heinämäki, Jaan Aruväli, Tuomas Ervasti, Karin Kogermann, Jarkko Ketolainen
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 158
Hot-melt extruded (HME) filaments are an essential intermediate product for the three- dimensional (3D) printing of drug delivery systems (DDSs) by the fused deposition modelling (FDM) process. The aim of this study was to design novel polymeric 3D-p