'Glyco-sulfo barcodes' regulate chemokine receptor function

Autor: Lisa Verhallen, Jarkko J. Lackman, Rikke Wendt, Martin Gustavsson, Zhang Yang, Yoshiki Narimatsu, Daniel M. Sørensen, Kato Mac Lafferty, Mieke Gouwy, Pedro E. Marques, Gertrud M. Hjortø, Mette M. Rosenkilde, Paul Proost, Christoffer K. Goth

Publikováno v: Verhallen, L, Lackman, J J, Wendt, R, Gustavsson, M, Yang, Z, Narimatsu, Y, Sørensen, D M, Lafferty, K M, Gouwy, M, Marques, P E, Hjortø, G M, Rosenkilde, M M, Proost, P & Goth, C K 2023, ' “Glyco-sulfo barcodes” regulate chemokine receptor function ', Cellular and Molecular Life Sciences, vol. 80, no. 2, 55 . https://doi.org/10.1007/s00018-023-04697-9

Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including O-glycosylation and tyrosine sulfation have been reported to regulate ligand binding and resulting sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6526cd97ea1fe546f51b09c8129a33f
https://doi.org/10.1007/s00018-023-04697-9

Site-specific O -glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane

Autor: Christoffer K. Goth, Sergey Y. Vakhrushev, Adnan Halim, Ulla E. Petäjä-Repo, Jarkko J. Lackman, Henrik Clausen

Publikováno v: Cellular Signalling. 42:184-193

G protein-coupled receptors (GPCRs) are an important protein family of signalling receptors that govern a wide variety of physiological functions. The capacity to transmit extracellular signals and the extent of cellular response are largely determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996e0f749631e7d5a3bd0a8bfa8c30e4
https://doi.org/10.1016/j.cellsig.2017.10.016

The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated

Autor: Inderjeet Kaur, Jarkko J. Lackman, Petri Kursula, Valerio Izzi, Ulla E. Petäjä-Repo, Salla Ruskamo, Ritva Heljasvaara, Taina Pihlajaniemi, Jarkko Koivunen

Publikováno v: The Biochemical journal. 475(22)

Collagen XVIII (ColXVIII) is a non-fibrillar collagen and proteoglycan that exists in three isoforms: short, medium and long. The medium and long isoforms contain a unique N-terminal domain of unknown function, DUF959, and our sequence-based secondar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41a435b0c06efb0aa670bc13e97b795
https://pubmed.ncbi.nlm.nih.gov/30327321

β-Adrenergic Agonists Mediate Enhancement of β1-Adrenergic Receptor N-terminal Cleavage and Stabilization In Vivo and In Vitro

Autor: Johanna Ulvila, Hamayun Khan, Anna E. Hakalahti, Miia M. Vierimaa, Emilia H. Pekkala, Risto Kerkelä, Ulla E. Petäjä-Repo, Jarkko J. Lackman

Publikováno v: Molecular Pharmacology. 83:129-141

The β(1)-adrenergic receptor (β(1)AR) is the predominant βAR in the heart and is the main target for β-adrenergic antagonists, widely used in the treatment of cardiovascular diseases. Previously, we have shown that the human (h) β(1)AR is cleave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78314c3182c2247858d84d025c89407d
https://doi.org/10.1124/mol.112.080440

Targeting opioid receptors with pharmacological chaperones

Autor: Jarkko J. Lackman, Ulla E. Petäjä-Repo

Publikováno v: Pharmacological research. 83

G protein-coupled receptors (GPCRs) are polytopic membrane proteins that have a pivotal role in cellular signaling. Like other membrane proteins, they fold in the endoplasmic reticulum (ER) before they are transported to the plasma membrane. The ER q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d5a6e82ad7cf71ecbced89acb563e9
https://pubmed.ncbi.nlm.nih.gov/24355364