Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jarkko, Koivunen"'
Autor:
Riitta Kaarteenaho, Oula Norman, Jarkko Koivunen, Antti M Salo, Joni M Mäki, Johanna Myllyharju, Taina Pihlajaniemi, Anne Heikkinen
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usu
Externí odkaz:
https://doaj.org/article/ac36a204554a4f418330e724704750ba
Autor:
Guillermo A. Martínez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petäistö, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Mäki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in vario
Externí odkaz:
https://doaj.org/article/a42f98c2b506481b89f70daf56c95400
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276215 (2022)
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with a poor prognosis and few treatment options. In the most widely used experimental model for this disease, bleomycin is administered into the lungs of mice, causing a reaction of inflamm
Externí odkaz:
https://doaj.org/article/53ad385b25ea4a57afa6042d55f2ba6a
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Matrix Biology Plus, Vol 1, Iss , Pp - (2019)
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome. Stud
Externí odkaz:
https://doaj.org/article/fe32c318bc4f4fda961b345e4f936469
Autor:
Juho Kontio, Valeria Rolle Soñora, Vilma Pesola, Rijuta Lamba, Annalena Dittmann, Ander Diaz Navarro, Jarkko Koivunen, Taina Pihlajaniemi, Valerio Izzi
Publikováno v:
Scopus
The extracellular matrix (ECM) is a three-dimensional network of proteins of diverse nature, whose interactions are essential to provide tissues with the correct mechanical and biochemical cues they need for proper development and homeostasis. Change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a686b769d5dd7a4ae8cba8eaec004
https://doi.org/10.1016/j.matbio.2022.05.006
https://doi.org/10.1016/j.matbio.2022.05.006
Autor:
Taina Pihlajaniemi, Mari Aikio, Mikko A. J. Finnilä, Tiina Petäistö, Raman Devarajan, David Vicente, Sanna-Maria Karppinen, Ilkka Miinalainen, Jérôme Thevenot, Kari A. Mäkelä, Ritva Heljasvaara, Jarkko Koivunen, Valerio Izzi, Karl-Heinz Herzig
Publikováno v:
Journal of Physiology
Key points Extracellular matrix is highly remodelled in obesity and associates with the development of metabolic disorders, such as insulin resistance. Previously, we have shown that the lack of specific collagen XVIII isoforms impairs adipocyte diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774c133f646324e8264a6311be6191a3
https://doi.org/10.1113/jp279559
https://doi.org/10.1113/jp279559
Autor:
Valerio Izzi, Taina Pihlajaniemi, Ritva Heljasvaara, Jarkko Koivunen, Anne Heikkinen, Sanna-Maria Karppinen
Publikováno v:
Seminars in Cancer Biology. 62:134-148
The extracellular matrix (ECM) is ubiquitously involved in neoplastic transformation, tumour growth and metastatic dissemination, and the interplay between tumour and stromal cells and the ECM is now considered crucial for the formation of a tumour-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae36ae7ad43043b939a82b286e0ba9f
https://doi.org/10.1016/j.semcancer.2019.08.033
https://doi.org/10.1016/j.semcancer.2019.08.033
Autor:
Heli Ruotsalainen, Kaur I, Taina Pihlajaniemi, Ronkainen, Akram Su, Florence Naillat, Jarkko Koivunen, Seppo Vainio, Ilkka Pietilä, Aki Manninen, Rinta-Jaskari Mm, Sasaki T, Izzi, Harri Elamaa
Collagen XVIII (ColXVIII) is a component of the extracellular matrix implicated in embryogenesis and control of homeostasis. We provide evidence that ColXVIII has a specific role in kidney ontogenesis by regulating the interaction between mesenchymal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1483a7953ba1b8b8c2c90b959e4a7595
https://doi.org/10.1101/2021.03.08.434365
https://doi.org/10.1101/2021.03.08.434365
Autor:
Elisa Holstein, Jarkko Koivunen, Vilma Pesola, Alexandra Naba, Anni Kääriäinen, Annalena Dittmann, Taina Pihlajaniemi, Valerio Izzi
Publikováno v:
Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1081, p 1081 (2021)
Volume 13
Issue 5
Cancers, Vol 13, Iss 1081, p 1081 (2021)
Background: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b329c2469a3105dcb152fb3d67a4c9a
Autor:
Jarkko Koivunen, Anne Heikkinen, Mikko A. J. Finnilä, Padmanabhan Anbazhagan, André H. Juffer, Hongmin Tu, Donald Gullberg, Jarmo Käpylä, Antti Kemppainen, Jyrki Heino, Ning Lu, Simo Saarakkala, Taina Pihlajaniemi
Publikováno v:
Cell and Tissue Research
Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors that mediate signals from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c3bc7a4efd89e69237844b1855f3d
https://static-content.springer.com/esm/art:10.1007/s00441-020-03300-y/MediaObjects/441_2020_3300_MOESM1_ESM.pdf
https://static-content.springer.com/esm/art:10.1007/s00441-020-03300-y/MediaObjects/441_2020_3300_MOESM1_ESM.pdf