Výsledky vyhledávání - "Jarig Darbes"

Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia

Autor: Erjia Wang, Frank D. Sistare, Katerina Vlasakova, Jude Ferraro, Yi-Zhong Gu, Jarig Darbes, Warren E. Glaab

Publikováno v: Toxicology. 439

Drug-induced kidney injury (DIKI) is a frequent occurrence in nonclinical drug development. It is well established that novel urine kidney safety biomarkers will outperform urea nitrogen (BUN) and serum creatinine (sCr) for monitoring direct drug inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82e91f2012dc73002a1d60b92e74360
https://pubmed.ncbi.nlm.nih.gov/32348786

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Regulatory Forum Commentary* Counterpoint

Autor: Jarig Darbes, Frank D. Sistare, Joseph J. DeGeorge

Publikováno v: Toxicologic Pathology. 43:621-627

High-dose selection for 6-month carcinogenicity studies of pharmaceutical candidates in Tg.rasH2-transgenic mice currently primarily relies on (1) estimation of a maximum tolerated dose (MTD) from the results of a 1-month range-finding study, (2) det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd68faa2d3d12641c3780098e963a8f
https://doi.org/10.1177/0192623315587722

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