The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Autor: Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Gerbal-Chaloin, Sabine, Gondeau, Claire, Vo, Dang-Nghiem, Belkahla, Sana, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Bozic, Milica, Valdivielso, Jose M., Bejjani, Fabienne, Jariel, Isabelle, Lopez-Mejia, Isabel C., Fajas, Lluis, Lecellier, Charles-Henri, Hernandez, Javier, Daujat, Martine, Villalba, Martin

Publikováno v: Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Scientific reports, vol. 7, no. 1, pp. 10654
Repositorio Abierto de la UdL
Universitad de Lleida

Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism can also modify lipid metabolism and hence cholesterol plasma levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bbeed3fffbef84478d27734b17774dee
http://europepmc.org/articles/PMC5587676