Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jari Häkkinen"'
Autor:
Völundur Hafstað, Jari Häkkinen, Malin Larsson, Johan Staaf, Johan Vallon-Christersson, Helena Persson
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Genomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and non-coding RNAs. In some cancer types, fusions involving specific kinases are used as targets for t
Externí odkaz:
https://doaj.org/article/9ff2da0262514696b39df8415e9a8fba
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background In cancer, genomic rearrangements can create fusion genes that either combine protein-coding sequences from two different partner genes or place one gene under the control of the promoter of another gene. These fusion genes can ac
Externí odkaz:
https://doaj.org/article/5cdbaa78e4fc4c5bb2e5ba32e33d7122
Autor:
Sunniva Stordal Bjørklund, Miriam Ragle Aure, Jari Häkkinen, Johan Vallon-Christersson, Surendra Kumar, Katrine Bull Evensen, Thomas Fleischer, Jörg Tost, OSBREAC, Kristine K. Sahlberg, Anthony Mathelier, Gyan Bhanot, Shridar Ganesan, Xavier Tekpli, Vessela N. Kristensen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Long non-coding RNAs (lncRNAs) have been shown to be involved in breast cancer pathogenesis through regulation of multiple steps of gene expression. lncRNA expression patterns are also associated with breast cancer clinicopathological features in lar
Externí odkaz:
https://doaj.org/article/d578e026b6684471a4b2a49871d7ef32
Autor:
Johan Staaf, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Siker Kimbung, Ingrid Hedenfalk, Tonje Lien, Therese Sørlie, Bjørn Naume, Hege Russnes, Rachel Marcone, Ayyakkannu Ayyanan, Cathrin Brisken, Rebecka R. Malterling, Bengt Asking, Helena Olofsson, Henrik Lindman, Pär-Ola Bendahl, Anna Ehinger, Christer Larsson, Niklas Loman, Lisa Rydén, Martin Malmberg, Åke Borg, Johan Vallon-Christersson
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (
Externí odkaz:
https://doaj.org/article/d2e56c524d0b4a448d746df4499518bd
Autor:
Mattias Aine, Ceren Boyaci, Johan Hartman, Jari Häkkinen, Shamik Mitra, Ana Bosch Campos, Emma Nimeus, Anna Ehinger, Johan Vallon-Christersson, Åke Borg, Johan Staaf
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-19 (2021)
Abstract Background Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed
Externí odkaz:
https://doaj.org/article/4912f58ed9244a1e8245e5010d96291a
Autor:
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.
Externí odkaz:
https://doaj.org/article/364ce59486504bf6a831a413fa23b595
Autor:
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon‐Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony M George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Åke Borg, Lao H Saal
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective
Externí odkaz:
https://doaj.org/article/36861d41d6c2406c82e4c1a71682a95f
Autor:
Mattias Aine, Ceren Boyaci, Johan Hartman, Jari Häkkinen, Shamik Mitra, Ana Bosch Campos, Emma Nimeus, Anna Ehinger, Johan Vallon-Christersson, Åke Borg, Johan Staaf
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-2 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/3660aa64683849c0a47efc9eaf8c9b40
Autor:
Helena Persson, Rolf Søkilde, Jari Häkkinen, Anna Chiara Pirona, Johan Vallon-Christersson, Anders Kvist, Fredrik Mertens, Åke Borg, Felix Mitelman, Mattias Höglund, Carlos Rovira
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Fusion gene research traditionally focuses on fusions that result in hybrid proteins or promoter switching events. Here, the authors demonstrate enrichment of fusions in miRNA host genes in breast cancer, highlighting that disparate fusions could hav
Externí odkaz:
https://doaj.org/article/1df00dd412b84dc780810f851b6a2ebb
Autor:
Bengt Phung, Maciej Cieśla, Adriana Sanna, Nicola Guzzi, Giulia Beneventi, Phuong Cao Thi Ngoc, Martin Lauss, Rita Cabrita, Eugenia Cordero, Ana Bosch, Frida Rosengren, Jari Häkkinen, Klaus Griewank, Annette Paschen, Katja Harbst, Håkan Olsson, Christian Ingvar, Ana Carneiro, Hensin Tsao, Dirk Schadendorf, Kristian Pietras, Cristian Bellodi, Göran Jönsson
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3573-3586.e7 (2019)
Summary: The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how DDX3X dysfunction specifically rewires gene
Externí odkaz:
https://doaj.org/article/f9c312bb787c493281030071690d30e4