Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jari E. Heikkilä"'
Publikováno v:
Pharmaceuticals, Vol 5, Iss 6, Pp 665-673 (2012)
Cholera remains a serious health problem, especially in developing countries where basic hygiene standards are not met. The symptoms of cholera are caused by cholera toxin, an enterotoxin, which is produced by the bacterium Vibrio cholerae. We have r
Externí odkaz:
https://doaj.org/article/23bf1fc7ffcc4523a7f16123e02a7c05
Autor:
Ari E. Hinkkanen, Veli-Matti Kähäri, Markku A. Kallajoki, Vasily A. Zakhartchenko, Jari E. Heikkilä, Linda C. Jansson, Janne P. Kallio, Markus J.V. Vähä-Koskela
Supplementary Figures 1-3 from Oncolytic Capacity of Attenuated Replicative Semliki Forest Virus in Human Melanoma Xenografts in Severe Combined Immunodeficient Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bacb9be06f26228d5cb84f9ba8af168
https://doi.org/10.1158/0008-5472.22364163
https://doi.org/10.1158/0008-5472.22364163
Autor:
Ari E. Hinkkanen, Veli-Matti Kähäri, Markku A. Kallajoki, Vasily A. Zakhartchenko, Jari E. Heikkilä, Linda C. Jansson, Janne P. Kallio, Markus J.V. Vähä-Koskela
Oncolytic viruses have gained attention as a novel form of cancer treatment. Many viral vectors in use today have been rendered safe by deletion of genes encoding viral structural proteins, thus making them unable to spread beyond the first infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b8163a62003ca28ae80e63346e988
https://doi.org/10.1158/0008-5472.c.6494040.v1
https://doi.org/10.1158/0008-5472.c.6494040.v1
Autor:
Kati M Tarkkonen, Emeli M Nilsson, Tiina E Kähkönen, Julien H Dey, Jari E Heikkilä, Johanna M Tuomela, Qing Liu, Nancy E Hynes, Pirkko L Härkönen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49970 (2012)
Fibroblast growth factors (FGFs) regulate the growth and progression of breast cancer. FGF signaling is transduced through FGF receptors 1-4, which have oncogenic or anti-oncogenic roles depending on the ligand and the cellular context. Our aim was t
Externí odkaz:
https://doaj.org/article/f9b86713200448d0bd2888a412913140
Autor:
Jari E Heikkilä, Markus J V Vähä-Koskela, Janne J Ruotsalainen, Miika W Martikainen, Marianne M Stanford, J Andrea McCart, John C Bell, Ari E Hinkkanen
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8603 (2010)
VA7 is a neurotropic alphavirus vector based on an attenuated strain of Semliki Forest virus. We have previously shown that VA7 exhibits oncolytic activity against human melanoma xenografts in immunodeficient mice. The purpose of this study was to de
Externí odkaz:
https://doaj.org/article/9e3d7804e4a04a5ba6d78d9f1539f147
Autor:
Janne Ruotsalainen, Jari E. Heikkilä, Pirkko Härkönen, Johanna Tuomela, Miika Martikainen, Ari Hinkkanen, Magnus Essand
Publikováno v:
British Journal of Cancer
Background: Despite recent therapeutic and diagnostic advances, prostate cancer remains the second leading cause of cancer-related deaths among men in the Western world. Oncolytic viruses that replicate selectively in tumour cells represent a novel t
Autor:
Tytti Aaltonen, Ari Hinkkanen, Minna Niittykoski, Tuulia Huhtala, Janne Ruotsalainen, John C. Bell, Markus Vähä-Koskela, Miika Martikainen, Jari E. Heikkilä
Publikováno v:
Molecular Therapy. 20:1529-1539
In our recent study, replicative alphaviral vector VA7 was found to be effective against orthotopic human U87-glioma xenografts in an athymic mouse model eradicating the tumors with single intravenous (i.v.) injection. Here, we tested the efficacy of
Publikováno v:
Pharmaceuticals
Pharmaceuticals; Volume 5; Issue 6; Pages: 665-673
Pharmaceuticals, Vol 5, Iss 6, Pp 665-673 (2012)
Pharmaceuticals; Volume 5; Issue 6; Pages: 665-673
Pharmaceuticals, Vol 5, Iss 6, Pp 665-673 (2012)
Cholera remains a serious health problem, especially in developing countries where basic hygiene standards are not met. The symptoms of cholera are caused by cholera toxin, an enterotoxin, which is produced by the bacterium Vibrio cholerae. We have r
Autor:
Sonja Balthasar, Nina Bergelin, Christoffer Löf, J. P. Slotte, Kid Törnquist, Tomas Blom, Jari E. Heikkilä, C. Alam, Ari Hinkkanen
Publikováno v:
Endocrinology. 150:2055-2063
Sphingosine 1-phosphate (S1P) induces migration of the human thyroid follicular carcinoma cell line ML-1 by activation of S1P1 and S1P3 receptors, Gi proteins, and the phosphatidylinositol 3-kinase-Akt pathway. Because sphingosine kinase isoform 1 (S
Autor:
Tiina I. Kuusinen, Markus Vähä-Koskela, Jari E. Heikkilä, Petra T. Furu, Jeanette C. Holmlund-Hampf, Ari Hinkkanen
Publikováno v:
Biochemical and Biophysical Research Communications. 355:776-781
Cytokine immunomodulation of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, has remained a formidable treatment option, but access into the CNS is hampered due to the impermeability of the blood–brain barrier. In t