Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Jari, Koistinaho"'
Autor:
Sanni Peltonen, Tuuli-Maria Sonninen, Jonna Niskanen, Jari Koistinaho, Marika Ruponen, Šárka Lehtonen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson’s disease (PD). Still, there is a lack of studies on the impact of pericytes on neu
Externí odkaz:
https://doaj.org/article/40491bcb47914518b2652d7ebe326de0
Autor:
Naďa Majerníková, Alejandro Marmolejo-Garza, Casandra Salinas Salinas, Minh D. A. Luu, Yuequ Zhang, Marina Trombetta-Lima, Tamara Tomin, Ruth Birner-Gruenberger, Šárka Lehtonen, Jari Koistinaho, Justina C. Wolters, Scott Ayton, Wilfred F. A. den Dunnen, Amalia M. Dolga
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) affects millions of people worldwide and represents the most prevalent form of dementia. Treatment strategies aiming to interfere with the formation of amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs), t
Externí odkaz:
https://doaj.org/article/b3a270feb1264fceb2a93bf047d1b14d
Autor:
Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. P
Externí odkaz:
https://doaj.org/article/ff2355ab447b4ba585cb169fd9c26369
Autor:
Meike Hedwig Keuters, Velta Keksa-Goldsteine, Taisia Rõlova, Merja Jaronen, Pinja Kettunen, Aurora Halkoluoto, Gundars Goldsteins, Jari Koistinaho, Hiramani Dhungana
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Stroke is a leading cause of permanent disability worldwide. Despite intensive research over the last decades, key anti-inflammatory strategies that have proven beneficial in pre-clinical animal models have often failed in translation. The i
Externí odkaz:
https://doaj.org/article/e14cbe37fa6d42fea676aeada9103100
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-30 (2024)
Abstract Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger neuroinflammation which is considered integrally involved in neurodegenerative processes. In
Externí odkaz:
https://doaj.org/article/09f48696ee7d4fe1a343dcff230c3dcf
Autor:
Noora Räsänen, Jari Tiihonen, Marja Koskuvi, Šárka Lehtonen, Nelli Jalkanen, Nelli Karmila, Isabelle Weert, Olli Vaurio, Ilkka Ojansuu, Markku Lähteenvuo, Olli Pietiläinen, Jari Koistinaho
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 4, Pp 100313- (2024)
Background: Development of synaptic activity is a key neuronal characteristic that relies largely on interactions between neurons and astrocytes. Although astrocytes have known roles in regulating synaptic function and malfunction, the use of human-
Externí odkaz:
https://doaj.org/article/e7359c272ddf44e5beee97c07010e73c
Autor:
Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm, Paula Korhonen
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased
Externí odkaz:
https://doaj.org/article/2ffcedbcf3f049898ce5fdfb9dd94b96
Autor:
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract LRRK2-G2019S is one of the most common Parkinson’s disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/cbf0d639bf06480ebb4d53aab63905d3
Autor:
Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Asmaa Oun, Jasmijn Hunneman, Tingting Chen, Jari Koistinaho, Sarka Lehtonen, Arjan Kortholt, Justina C. Wolters, Barbara M. Bakker, Bart J. L. Eggen, Erik Boddeke, Amalia Dolga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other metabolic pathways. However
Externí odkaz:
https://doaj.org/article/84b22256347c40f5852d44e2ee2ceacc
Autor:
Samu N. Kurki, Tommi Ala-Kurikka, Arto Lipponen, Alexey S. Pospelov, Taisia Rolova, Jari Koistinaho, Juha Voipio, Kai Kaila
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Systemic inflammation triggers protective as well as pro-inflammatory responses in the brain based on neuronal and/or cytokine signaling, and it associates with acutely and protractedly disrupted cognition. However, the multiple mechanisms u
Externí odkaz:
https://doaj.org/article/376659392dc3419fb363aec0e9bb8365