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Autor:
Hui K. Gan, Sagun Parakh, F. T. Lee, Niall C. Tebbutt, Malaka Ameratunga, Sze Ting Lee, Graeme J. O’Keefe, Sylvia J. Gong, Christine Vanrenen, Jaren Caine, Mara Giovannetti, Carmel Murone, Fiona E. Scott, Nancy Guo, Ingrid J. G. Burvenich, Cameron Paine, Mary J. Macri, Masakatsu Kotsuma, Giorgio Senaldi, Ralph Venhaus, Andrew M. Scott
Publikováno v:
Investigational new drugs. 40(4)
Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and biodistribution study of DS-8895a, an anti-EphA2 antibody, in patients with advanced EphA2 positive cancers. DS-8895a was