Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jared W. Fennell"'
Autor:
Michael J. Burns, Ian X. Andrews, Jens-Christoph Baumann, Eric L. Elliott, Jared W. Fennell, Jeffrey M. Kallemeyn, Sebastien Lemaire, Natasha S. Murphy, Magali Palacio, Steven A. Raw, Alastair J. Roberts, Nayrton Flávio Moura Rocha, Didier Schils, Rolf Schulte Oestrich, Andrew L. Shannon-Little, Neil Stevenson, Pere Talavera, Andrew Teasdale, Michael W. Urquhart, Fernanda Waechter
Publikováno v:
Organic Process Research & Development.
Publikováno v:
Journal of Pharmaceutical Innovation. 16:302-316
Due to the exceptionally high standards for accuracy and data integrity in scientific regulatory reporting, it is vital that any tool that aims to streamline this process is as efficient or more in gathering data as a team of scientists, without high
Autor:
Jens-Christoph Baumann, Nathan D. Ide, Neil G. Stevenson, Didier Schils, Pere Talavera, Jared W. Fennell, Lucie E. Lovelle, David P. Elder, Vincent Antonucci, Michael J. Burns, Dirk Lauwers, Andrew Teasdale, Michael Urquhart, Tetsuji Itoh, Dennie S. Welch, Roland Brown, Rolf Schulte Oestrich, Susanne A. Stalford, Jeffrey M. Kallemeyn, Robert Molzahn, Varie David Lee, Elizabeth M. Covey-Crump, Gregory W. Sluggett, Fabrice Gallou, Guido Jordine, Martin A. Ott, Eric L. Elliott, Looker Adam
Publikováno v:
Organic Process Research & Development. 23:2470-2481
The ICH M7 guidance provides a series of flexible control options for the control of (potentially) mutagenic impurities (PMIs) that fully align with key risk-based principles. This includes option ...
Autor:
Yu Lu, David Mitchell, Jared W. Fennell, Todd D. Maloney, Ramesh Subbiah, Kevin P. Cole, Balakumar Ramadas
Publikováno v:
Organic Process Research & Development. 22:409-419
A new synthesis of a key indazole-containing building block for the MET kinase inhibitor merestinib was designed and demonstrated. Crucial to the successful construction of the challenging indazole is an SNAr reaction, which forges the heterocyclic r
Autor:
Dirk Lauwers, Guido Jordine, David P. Elder, Varie David Lee, Neil G. Stevenson, Mark McLaughlin, Eric L. Elliott, Jens-Christoph Baumann, Barber Christopher Gordon, Nathan D. Ide, Jeffrey M. Kallemeyn, Lucie E. Lovelle, Elizabeth M. Covey-Crump, Andrew Teasdale, Jared W. Fennell, Fabrice Gallou, Looker Adam, Pere Talavera, Martin A. Ott, Didier Schils, Roland Brown, Rolf Schulte Oestrich, Vincent Antonucci, Michael Urquhart, Robert Molzahn, Dennie S. Welch
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 90
The ICH M7 Option 4 control of (potentially) mutagenic impurities is based on the use of scientific principles in lieu of routine analytical testing. This approach can reduce the burden of analytical testing without compromising patient safety, provi
Autor:
Thomas M. Koenig, Hossam Moursy, Norma Scully, Utpal K. Singh, Neil J. Kallman, Jonas Y. Buser, Jeremy M. Merritt, Alison N. Campbell, Jared W. Fennell, Mark A. Pietz
Publikováno v:
Organic Process Research & Development. 18:246-256
A mechanistic approach was undertaken to understand the oxygen sensitivity of a Pd-catalyzed amination reaction used in the synthesis of an active pharmaceutical ingredient. FlowNMR and dissolved oxygen probes were used as process analytical technolo
Autor:
Edward W. Conder, Roger Ryan Rothhaar, Mark A. LaPack, Jared W. Fennell, Timothy M. Braden, R. Brian Scherer, Jeffrey Czarnik, Jeffrey Thomas Vicenzi, Mark D. Argentine, Jeffrey G. Wei, John Arnold Werner, Robert T. Roginski, Schmid Christopher Randall, Steven E. Dunlap
Publikováno v:
Organic Process Research & Development. 13:131-143
The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich e
Publikováno v:
Synthesis. 2006:2659-2664
An alternate synthesis of title compound (5) using N-(2-methoxycarbonyl-1-methylvinyl)-L-alanine sodium salt (6) and 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (1) was successfully completed. Incorporation of silyl ester protection and the use
Autor:
Harrie Straatman, David J. Ager, Jared W. Fennell, John Arnold Werner, Johannes G. de Vries, Kevin A. Sullivan, Mark D. Argentine, Natascha Sereinig, Todd D. Maloney, Roger B. Scherer, Laurent Lefort
Publikováno v:
Catalysis Science & Technology. 2:2077
A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline. An extensive screen using parallel reactors was conducted and led to the d
Autor:
Mark D. Argentine, Timothy M. Braden, Jeffrey Czarnik, Edward W. Conder, Steven E. Dunlap, Jared W. Fennell, Mark A. LaPack, Roger R. Rothhaar, R. Brian Scherer, Christopher R. Schmid, Jeffrey T. Vicenzi, Jeffrey G. Wei, John A. Werner, Robert T. Roginski
Publikováno v:
Organic Process Research & Development; Mar2009, Vol. 13 Issue 2, p131-143, 13p