Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jared T, Winkelman"'
Autor:
Gong Chen, Georgia Fanouraki, Aathmaja Anandhi Rangarajan, Bradford T. Winkelman, Jared T. Winkelman, Christopher M. Waters, Sampriti Mukherjee
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT The human pathogen Pseudomonas aeruginosa, a leading cause of hospital-acquired infections, inhabits and forms sessile antibiotic-resistant communities called biofilms in a wide range of biotic and abiotic environments. In this study, we exa
Externí odkaz:
https://doaj.org/article/40d99e9ad8044d7a875115e5e4dc326f
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections and formation of sessile antibiotic-resistant communities called biofilms is required for virulence in this pathogen. Biofilm formation is modulated by various environmental st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18357d79b4ed717511719034d889f56d
https://doi.org/10.1101/2022.09.27.509822
https://doi.org/10.1101/2022.09.27.509822
Autor:
Libing Yu, Jared T Winkelman, Chirangini Pukhrambam, Terence R Strick, Bryce E Nickels, Richard H Ebright
Publikováno v:
eLife, Vol 6 (2017)
During transcription initiation, RNA polymerase (RNAP) binds to promoter DNA, unwinds promoter DNA to form an RNAP-promoter open complex (RPo) containing a single-stranded ‘transcription bubble,’ and selects a transcription start site (TSS). TSS
Externí odkaz:
https://doaj.org/article/2d49093760cc467685caa7eb25216807
Autor:
Chirangini Pukhrambam, Vadim Molodtsov, Mahdi Kooshkbaghi, Ammar Tareen, Hoa Vu, Kyle S. Skalenko, Min Su, Zhou Yin, Jared T. Winkelman, Justin B. Kinney, Richard H. Ebright, Bryce E. Nickels
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(23)
In σ-dependent transcriptional pausing, the transcription initiation factor σ, translocating with RNA polymerase (RNAP), makes sequence-specific protein-DNA interactions with a promoter-like sequence element in the transcribed region, inducing paus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9ce08beed7340bc479f97b438c74d1
https://pubmed.ncbi.nlm.nih.gov/35653571
https://pubmed.ncbi.nlm.nih.gov/35653571
Autor:
Richard H. Ebright, Chirangini Pukhrambam, Jason T. Kaelber, Jared T. Winkelman, Bryce E. Nickels, Emre Firlar, Yu Liu, Yu Zhang, Libing Yu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(5)
Reiterative transcription initiation, observed at promoters that contain homopolymeric sequences at the transcription start site, generates RNA products having 5’ sequences non-complementary to the DNA template. Here, using crystallography and cryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24847d76bc2230de9439d52728470c38
https://pubmed.ncbi.nlm.nih.gov/35082149
https://pubmed.ncbi.nlm.nih.gov/35082149
Autor:
Kyle S, Skalenko, Lingting, Li, Yuanchao, Zhang, Irina O, Vvedenskaya, Jared T, Winkelman, Alexander L, Cope, Deanne M, Taylor, Premal, Shah, Richard H, Ebright, Justin B, Kinney, Yu, Zhang, Bryce E, Nickels
Publikováno v:
Proc Natl Acad Sci U S A
Chemical modifications of RNA 5′-ends enable “epitranscriptomic” regulation, influencing multiple aspects of RNA fate. In transcription initiation, a large inventory of substrates compete with nucleoside triphosphates for use as initiating enti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a83e90107ae3e84ab3625e339457735d
https://pubmed.ncbi.nlm.nih.gov/34187896
https://pubmed.ncbi.nlm.nih.gov/34187896
Autor:
Lingting Li, Yuanchao Zhang, Irina O. Vvedenskaya, Bryce E. Nickels, Deanne Taylor, Kyle S. Skalenko, Premal Shah, Yu Zhang, Richard H. Ebright, Jared T. Winkelman, Justin B. Kinney, Alexander L. Cope
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Chemical modifications of RNA 5'-ends enable "epitranscriptomic" regulation, influencing multiple aspects of RNA fate. In transcription initiation, a large inventory of substrates compete with nucleoside triphosphates for use as initiating entities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d673f5619b1c52f0f2ad2c28c4e13fec
https://doi.org/10.1073/pnas.2106388118
https://doi.org/10.1073/pnas.2106388118
Autor:
Justin B. Kinney, Richard H. Ebright, Alexander L. Cope, Kyle S. Skalenko, Deanne Taylor, Bryce E. Nickels, Lingting Li, Yuanchao Zhang, Irina O. Vvedenskaya, Yu Zhang, Premal Shah, Jared T. Winkelman
Chemical modifications of RNA 5′ ends enable “epitranscriptomic” regulation, influencing multiple aspects of RNA fate. In transcription initiation, a large inventory of substrates compete with nucleoside triphosphates (NTPs) for use as initiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29451834a976c4596784163bb392168
https://doi.org/10.1101/2021.04.06.438613
https://doi.org/10.1101/2021.04.06.438613
Publikováno v:
RNA Polymerases as Molecular Motors ISBN: 9781788013659
RNA Polymerases as Molecular Motors
RNA Polymerases as Molecular Motors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df78b5b424325c2fa06b10801ab33e9
https://doi.org/10.1039/9781839160561-00001
https://doi.org/10.1039/9781839160561-00001
Autor:
Albert Y. Chen, Ruth M. Saecker, Michael F. Maloney, Brian T. Chait, C.E. Chiu, Seth A. Darst, Richard L. Gourse, Paul Dominic B. Olinares, Saumya Gopalkrishnan, Jared T. Winkelman, Wilma Ross, James Chen, Elizabeth A. Campbell
Publikováno v:
Mol Cell
Transcription initiation requires formation of the open promoter complex, RPo. To generate RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DNA into the RNAP active site. RPo formation is a multi-step p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6490d89602f04f825e9fad4e7f8eb7ab
https://europepmc.org/articles/PMC7166197/
https://europepmc.org/articles/PMC7166197/