Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jared T, Nordman"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010682 (2023)
Histones are essential for chromatin packaging, and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histo
Externí odkaz:
https://doaj.org/article/208f99fe5eba4b14988d2025e4bfd5eb
Autor:
Alexander Munden, Madison T. Wright, Dongsheng Han, Reyhaneh Tirgar, Lars Plate, Jared T. Nordman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Replication of the eukaryotic genome requires the formation of thousands of replication forks that must work in concert to accurately replicate the genetic and epigenetic information. Defining replication fork-associated proteins is a key st
Externí odkaz:
https://doaj.org/article/bf3c61eb9a554ecd80c35d1ef55d5ddc
Autor:
Dongsheng Han, Samantha H. Schaffner, Jonathan P. Davies, Mary Lauren Benton, Lars Plate, Jared T. Nordman
Publikováno v:
bioRxiv
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modifications likely contributes to disease states and cancer. Depletion of the chromatin-binding protein BRWD3, a known substrate-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d606dc4598f484180b51c6c3f6809
https://europepmc.org/articles/PMC10081218/
https://europepmc.org/articles/PMC10081218/
Publikováno v:
eLife, Vol 7 (2018)
Control of DNA copy number is essential to maintain genome stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-domain-containing SUUR protein inhibits replication fork progression within specific regions of t
Externí odkaz:
https://doaj.org/article/a87f4d63fb7f45cf9f60ab32581ca0e8
Histones are essential for chromatin packaging and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27fcd363501b23ed42b83345de184d
https://doi.org/10.1101/2022.09.16.508322
https://doi.org/10.1101/2022.09.16.508322
Autor:
Jared T. Nordman, Elena N. Kozhevnikova, C. Peter Verrijzer, Alexey V. Pindyurin, Evgeniya N. Andreyeva, Victor V. Shloma, Igor F. Zhimulev, Terry L. Orr-Weaver
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 841-849 (2014)
Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level
Externí odkaz:
https://doaj.org/article/cc7040ae1ade46059c2951a32cdf234f
Publikováno v:
Genetics
Replication initiation in eukaryotic cells occurs asynchronously throughout S phase, yielding early and late replicating regions of the genome, a process known as replication timing (RT). RT changes during development to ensure accurate genome duplic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b26ac35d225c223bc0c2a10c6a1f2da
https://doi.org/10.1534/genetics.120.303155
https://doi.org/10.1534/genetics.120.303155
Publikováno v:
Genes. 13(3)
Successful duplication of the genome requires the accurate replication of billions of base pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome results in genomic instability and a host of diseases. To faithfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdacd04d150e961d5ed7af6852c56b2
https://pubmed.ncbi.nlm.nih.gov/35328102
https://pubmed.ncbi.nlm.nih.gov/35328102
R-loops are involved in transcriptional regulation, DNA and histone post-translational modifications, genome replication and genome stability. To what extent R-loop abundance and genome-wide localization is actively regulated during metazoan embryoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dc8354140b4dcf805f969abf8bb269
https://doi.org/10.1101/2021.10.29.465954
https://doi.org/10.1101/2021.10.29.465954