Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jared T, Hammill"'
Autor:
Aditya H. Gaur, John C. Panetta, Amber M. Smith, Ronald H. Dallas, Burgess B. Freeman, III, Tracy B. Stewart, Li Tang, Elizabeth John, Kristen C. Branum, Nehali D. Patel, Shelley Ost, Ryan N. Heine, Julie L. Richardson, Jared T. Hammill, Lidiya Bebrevska, Fabian Gusovsky, Noritsugu Maki, Toshiharu Yanagi, Patricia M. Flynn, James S. McCarthy, Stephan Chalon, R. Kiplin Guy
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104065- (2022)
Summary: Background: SJ733, a newly developed inhibitor of P. falciparum ATP4, has a favorable safety profile and rapid antiparasitic effect but insufficient duration to deliver a single-dose cure of malaria. We investigated the safety, tolerability,
Externí odkaz:
https://doaj.org/article/d8cb0aafdaa14141ac20c3e2254e7c3d
Autor:
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006157 (2017)
Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the ne
Externí odkaz:
https://doaj.org/article/fd582fbd68d94e90b34293f3995c292e
Autor:
Kristin L. Begley, Amy L. Rice, Jean-Claude Dujardin, Jonah Rector, Vivek M. Rangnekar, Corinne M. Fargo, David S. Watt, Yizhe Chen, Diana Ortiz, Liliia M. Kril, Vitaliy M. Sviripa, Ho Shin Kim, Scott M. Landfear, Malgorzata A. Domagalska, Jared T. Hammill, Chunming Liu, R. Kiplin Guy
Publikováno v:
Journal of Medicinal Chemistry
Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a
Autor:
Kathleen O’Loughlin, Yizhe Chen, Lei Yang, Fangyi Zhu, Jared T. Hammill, Karen L. White, Gloria Holbrook, David M. Shackleford, Susan A. Charman, Jon C. Mirsalis, R. Kiplin Guy, Burgess B. Freeman
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
Malaria Journal
Malaria Journal
Background The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical ca
Autor:
Marc O. Anderson, Martina Sigal, Ashley Cheung, Jared T. Hammill, Anna S Kashtanova, Korina Eribez, Lauren Loop, Horacio Lazaro, Irene García-Barbazán, Cory A. Chaplan, Kenya Yniguez, Benigno Crespo, Alisje Churchyard, Mofolusho O. Falade, Grant Koch, Briana Belanger, Celine DiBernardo, Jake Baum, Julia E Tryhorn, Amy L. Rice, Katie Kim, Joshua J. Kimball, R. Kiplin Guy, Steven Wilkinson, Benoît Laleu, Nimisha Mittal, Rei Takahashi, Elizabeth A. Winzeler, Francisco-Javier Gamo, Scott Eagon, Kevin J Ahn
Publikováno v:
Journal of Medicinal Chemistry. 63:11902-11919
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines
Autor:
Jared T. Hammill, John R. Lloyd, Carole A. Bewley, Peter Wipf, Alberto Plaza, Jessica L. Keffer
Publikováno v:
Marine Drugs, Vol 10, Iss 5, Pp 1103-1125 (2012)
Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including c
Externí odkaz:
https://doaj.org/article/062a74ba013e475981dc668d76163fc5
Autor:
Brandon Nguyen, Julia Elizabeth Glidden, Scott Eagon, Kasey Fitzsimmons, Jared T. Hammill, Kara Thompson, Jarvis Law, Mofolusho O. Falade, Steven Wilkinson, Amy L. Rice, Celine DiBernardo, Natalie Sienko, R. Kiplin Guy, Aashrita Manjunath, Joshua J. Kimball
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
Malaria remains one of the deadliest diseases on the planet, infecting an estimated 229 million individuals in 2019 with more than 400,000 associated deaths, primarily in young children and pregnant women. 1 Malaria is caused by Plasmodium parasite i
Autor:
Bhuvanesh Singh, Yizhe Chen, William Pistel, R. Kiplin Guy, Amy L. Rice, Daniel C. Scott, Jared T. Hammill, Ho Shin Kim, Brenda A. Schulman
Publikováno v:
Journal of medicinal chemistry. 64(9)
The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction
Autor:
Bhuvanesh Singh, Jonah Rector, Jaeki Min, Brenda A. Schulman, R. Kiplin Guy, Jared T. Hammill, Ho Shin Kim, Daniel C. Scott, Yizhe Chen
Publikováno v:
J Med Chem
Chemical control of cullin neddylation is attracting increased attention based largely on the successes of the NEDD8-activating enzyme (E1) inhibitor Pevonedistat. Recently reported chemical probes enable selective and time-dependent inhibition of do
Autor:
Jordan Bach, Jared T. Hammill, Mofolusho O. Falade, R. Kiplin Guy, Scott Eagon, Nikalet Everson, Amy L. Rice
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
A virtual screen was performed to identify anti-malarial compounds targeting Plasmodium falciparum heat shock 90 protein by applying a series of drug-like and commercial availability filters to compounds in the ZINC database, resulting in a virtual l