Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jared S. Mackenzie"'
Autor:
Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death
Externí odkaz:
https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b
Autor:
Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB diseas
Externí odkaz:
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
Autor:
Tafara T. R. Kunota, Md. Aejazur Rahman, Barry E. Truebody, Jared S. Mackenzie, Vikram Saini, Dirk A. Lamprecht, John H. Adamson, Ritesh R. Sevalkar, Jack R. Lancaster, Michael Berney, Joel N. Glasgow, Adrie J. C. Steyn
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1285 (2021)
H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S has been shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role in Mtb phys
Externí odkaz:
https://doaj.org/article/fec3048b30624ab090468cbae2579f5b
Autor:
Asaf Stein, Jack R. Lancaster, Tafara T.R. Kunota, Shannon M. Bailey, Jared S. Mackenzie, Dirk A. Lamprecht, Adrie J. C. Steyn, Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Barry E. Truebody, Douglas R. Moellering, Md. Aejazur Rahman, John H. Adamson, Joel N. Glasgow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Hydrogen sulfide (H2S) is involved in numerous pathophysiological processes and shares overlapping functions with CO and •NO. However, the importance of host-derived H2S in microbial pathogenesis is unknown. Here we show that Mtb-infected mice defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa427814c223c5b5ff6ca38726388540
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
Autor:
Vikram Saini, Jared S. Mackenzie, Michael Berney, Md. Aejazur Rahman, Ritesh R. Sevalkar, Barry E. Truebody, John H. Adamson, Joel N. Glasgow, Jack R. Lancaster, Dirk A. Lamprecht, Tafara T.R. Kunota, Adrie J. C. Steyn
H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S has been shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role in Mtb phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83078bac349cca4be8f4514dcde0b9a7
https://doi.org/10.1101/2021.06.02.446746
https://doi.org/10.1101/2021.06.02.446746
Autor:
Sylvie Alonso, John Chan, Ekaterina N. Sviriaeva, Gerhard Grüber, Marvin J. Miller, Garrett C. Moraski, Vanessa Hui Qi Koh, Michael Berney, Jiayong Xu, Bei Shi Lee, Malathy Sony Subramanian Manimekalai, Dirk Schnappinger, Jared S. Mackenzie, Curtis A. Engelhart, Adrie J. C. Steyn, Kiel Hards, Kevin Pethe, Sherilyn Shi Min Chong, Erik J. Hasenoehrl, Nitin Pal Kalia, Gregory M. Cook
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules targeting other component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be61bb23a16a2d5337b93d0307834cf
https://doi.org/10.15252/emmm.202013207
https://doi.org/10.15252/emmm.202013207
Autor:
Adrie J. C. Steyn, Joel N. Glasgow, Dirk A. Lamprecht, Simon Rousseau, Khushboo Borah, John H. Adamson, Rukaya Asmal, Dany J. V. Beste, James C. Sacchettini, Bei Shi Lee, Inna Krieger, Kevin Pethe, Jared S. Mackenzie
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is not known precisely how BDQ triggers cell death in Mycobacterium tubercul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b25c4459dc9cdcf4168b39de95ebaec
https://doi.org/10.1038/s41467-020-19959-4
https://doi.org/10.1038/s41467-020-19959-4
Autor:
K. G. Papavinasasundaram, Jared S. Mackenzie, Eleni Jaecklein, Andrew J. Olive, Christopher M. Sassetti, Xinchun Chen, Yi Cai, Adrie J. C. Steyn
In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9171fea6beb3330e14cbda7fa4701422
https://doi.org/10.1101/2020.08.21.260737
https://doi.org/10.1101/2020.08.21.260737
Autor:
Yi Cai, Xinchun Chen, Eleni Jaecklein, Christopher M. Sassetti, K. G. Papavinasasundaram, Adrie J. C. Steyn, Jared S. Mackenzie, Andrew J. Olive
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1008911 (2021)
PLoS Pathogens, Vol 17, Iss 7, p e1008911 (2021)
In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd9e2a1c63902e0c43ae01e30f9c532
https://pubmed.ncbi.nlm.nih.gov/34320028
https://pubmed.ncbi.nlm.nih.gov/34320028
Autor:
Ian M. Mbano, Tafara T.R. Kunota, Manormoney Pillay, Tawanda Mandizvo, Jared S. Mackenzie, Frederick K. Balagaddé, Jerome Rogich
Publikováno v:
The journal of applied laboratory medicine. 5(3)
Background There is a well-documented lack of rapid, low-cost tuberculosis (TB) drug resistance diagnostics in low-income settings across the globe. It is these areas that are plagued with a disproportionately high disease burden and in greatest need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db26d0286061390184c5a884db17ffd
https://pubmed.ncbi.nlm.nih.gov/32445350
https://pubmed.ncbi.nlm.nih.gov/32445350