Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jared S. Bee"'
Autor:
Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang, Methal Albarghouthi
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
When two therapeutic agents are combined in a single formulation, i.e., coformulated, the quality and safety of the individual agents must be preserved. Here we describe an approach to evaluate the quality attributes of two individual monoclonal anti
Externí odkaz:
https://doaj.org/article/c401e00aa0004b988ffc64c379fc550f
Autor:
Jared S. Bee, Yu Zhang, Sheyla Finkner, Kristin O'Berry, Akanksha Kaushal, Megan Kuhn Phillippi, Roberto A. DePaz, Keith Webber, Tristan Marshall
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1868-1878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0551e5f55dd4f70c2b573e46271cbb97
https://doi.org/10.1016/j.xphs.2022.03.018
https://doi.org/10.1016/j.xphs.2022.03.018
Publikováno v:
Pharmaceutical Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da320722361a9123c0f889d8b8662f64
https://doi.org/10.1007/s11095-023-03485-1
https://doi.org/10.1007/s11095-023-03485-1
Publikováno v:
Pharmaceutical Research. 38:243-255
Reversible self-association (RSA) remains a challenge in the development of therapeutic monoclonal antibodies (mAbs). We recently analyzed the energetics of RSA for five IgG mAbs (designated as A-E) under matched conditions and using orthogonal metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c82c59f98abd5913b9b5c75f259b12
https://doi.org/10.1007/s11095-021-02987-0
https://doi.org/10.1007/s11095-021-02987-0
Autor:
Lu Shan, Magali Colazet, Kim L Rosenthal, Xiang-Qing Yu, Jared S Bee, Andrew Ferguson, Melissa M Damschroder, Herren Wu, William F Dall'Acqua, Ping Tsui, Vaheh Oganesyan
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160345 (2016)
The immunoglobulin Fc region is a homodimer consisted of two sets of CH2 and CH3 domains and has been exploited to generate two-arm protein fusions with high expression yields, simplified purification processes and extended serum half-life. However,
Externí odkaz:
https://doaj.org/article/91d568f9c0f24ee8beba1b700261d04c
Autor:
Bram Slütter, Jared S. Bee, Samuel A. Korman, Wim Jiskoot, Mark A. Schenerman, Yuling Wu, Grzegorz Kijanka
Publikováno v:
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, 109(1), 730-738
Journal of Pharmaceutical Sciences, 109(1), 730-738
The presence of protein aggregates is commonly believed to be an important risk factor for immunogenicity of therapeutic proteins. Among all types of aggregates, dimers are relatively abundant in most commercialized monoclonal antibody (mAb) products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7fc929162e616ebfb10a734232c12b
https://doi.org/10.1016/j.xphs.2019.04.021
https://doi.org/10.1016/j.xphs.2019.04.021
Autor:
Jared S, Bee, Yu, Zhang, Sheyla, Finkner, Kristin, O'Berry, Akanksha, Kaushal, Megan Kuhn, Phillippi, Roberto A, DePaz, Keith, Webber, Tristan, Marshall
Publikováno v:
Journal of pharmaceutical sciences. 111(7)
Gene therapies delivered using adeno-associated virus (AAV) vectors are showing promise for many diseases. Frozen AAV drug products are exposed to freeze-thaw (F/T) cycles during manufacturing, storage, and distribution. In this work we studied the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b88214ceab46d0dbf2b658c5db0f947
https://pubmed.ncbi.nlm.nih.gov/35351496
https://pubmed.ncbi.nlm.nih.gov/35351496
Autor:
Jared S. Bee, Yu (Zoe) Zhang, Megan Kuhn Phillippi, Sheyla Finkner, Tesfu Mezghebe, Keith Webber, Win Den Cheung, Tristan Marshall
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
There are an increasing number of clinical studies evaluating different adeno-associated virus (AAV) serotypes as vectors for gene therapy. Long-term frozen storage can maximize the stability of AAV. Freeze-thaw (F/T) cycles and exposures to room tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea2d47e2decad6afd915def76befa9c
https://pubmed.ncbi.nlm.nih.gov/34999092
https://pubmed.ncbi.nlm.nih.gov/34999092
Autor:
Swarnim Ranjan, David Robbins, Wai Keen Chung, Limin Zhang, Steven M. Cramer, Romina V. Hofele, Jared S. Bee, Jenny Heidbrink Thompson
Publikováno v:
Biotechnology and Bioengineering. 116:1684-1697
Cathepsin D has been identified as a challenge to remove in downstream bioprocessing of monoclonal antibodies (mAbs) due to interactions with some mAbs. This study focused on investigating the mechanisms of interaction between cathepsin D and two ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a06e55ee8d4fad8369b06b3fe3b607
https://doi.org/10.1002/bit.26968
https://doi.org/10.1002/bit.26968
Publikováno v:
International journal of pharmaceutics. 606
Adeno-associated viruses (AAV) are among the most actively investigated vectors for gene therapy. Supply of early clinical studies with frozen drug product (DP) can accelerate timelines and minimize degradation risks. In the long-term, logistical cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c087dd881b8ca9b258583d6755ac2fd
https://pubmed.ncbi.nlm.nih.gov/34298099
https://pubmed.ncbi.nlm.nih.gov/34298099