Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jared S Rosenblum"'
Autor:
LaYow C. Yu, Danielle D. Dang, Sophie Zhuang, Shuran Chen, Zhengping Zhuang, Jared S. Rosenblum
Publikováno v:
Cancer Pathogenesis and Therapy, Vol 1, Iss 2, Pp 111-115 (2023)
Carrimycin is a synthetic macrolide antibiotic that has been shown to have anti-cancer activity; however, its exact mechanism of action and molecular target were previously unknown. It was recently elucidated that Isovalerylspiramycin I (ISP I), the
Externí odkaz:
https://doaj.org/article/9651752da30841468a61fc6288919109
Autor:
Danielle D. Dang, Vikram Chandrashekhar, Vibhu Chandrashekhar, Nagela Ghabdanzanluqui, Russell H. Knutsen, Matthew A. Nazari, Likitha Nimmagadda, Danielle R. Donahue, Dorian B. McGavern, Beth A. Kozel, John D. Heiss, Karel Pacak, Zhengping Zhuang, Jared S. Rosenblum
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102367- (2023)
Summary: Mapping cranial vasculature and adjacent neurovascular interfaces in their entirety will enhance our understanding of central nervous system function in any physiologic state. We present a workflow to visualize in situ murine vasculature and
Externí odkaz:
https://doaj.org/article/ae9471c45db847b68da91dbec8d63a83
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 10, Pp 1428-1439 (2022)
Protein phosphatases play essential roles as negative regulators of kinases and signaling cascades involved in cytoskeletal organization. Protein phosphatase 2A (PP2A) is highly conserved and is the predominant serine/threonine phosphatase in the ner
Externí odkaz:
https://doaj.org/article/1be5051d52924dcb9bdfbfbf386153f3
Autor:
Danielle D. Dang, Jared S. Rosenblum, Ashish H. Shah, Zhengping Zhuang, Tara T. Doucet-O’Hare
Publikováno v:
Cancers, Vol 15, Iss 9, p 2511 (2023)
Originally approved in 1979, a specific grading classification for central nervous system (CNS) tumors was devised by the World Health Organization (WHO) in an effort to guide cancer treatment and better understand prognosis. These “blue books” h
Externí odkaz:
https://doaj.org/article/3cfeb11b98ab4ddf83663d4a181d1f66
Autor:
Tara T. Doucet-O’Hare, Brianna L. DiSanza, Catherine DeMarino, Abigail L. Atkinson, Jared S. Rosenblum, Lisa J. Henderson, Kory R. Johnson, Jeffrey Kowalak, Marta Garcia-Montojo, Sariah J. Allen, Brent A. Orr, Mariarita Santi, Tongguang Wang, Saeed Fathi, Myoung Hwa Lee, Kevon Sampson, Wenxue Li, Zhengping Zhuang, Avindra Nath
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 regulates Human Endogenous Retro
Externí odkaz:
https://doaj.org/article/b606f3bbb7b5473bafc41a2148c765eb
Autor:
Chuzhong Li, Weiyan Xie, Jared S. Rosenblum, Jianyu Zhou, Jing Guo, Yazhou Miao, Yutao Shen, Hongyun Wang, Lei Gong, Mingxuan Li, Sida Zhao, Sen Cheng, Haibo Zhu, Tao Jiang, Shiying Ling, Fei Wang, Hongwei Zhang, Mingshan Zhang, Yanming Qu, Qi Zhang, Guilin Li, Junmei Wang, Jun Ma, Zhengping Zhuang, Yazhuo Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The genetic basis of prolactinomas remains poorly understood. Here, the authors find a recurrent hotspot somatic mutation in the splicing factor 3 subunit B1 (SF3B1 R625H ) in prolactinomas, and show that this mutation causes aberrant splicing of ESR
Externí odkaz:
https://doaj.org/article/03819aa8e3fa4e1cb3bc7de1641abf1b
Autor:
Pashayar P. Lookian, Vikram Chandrashekhar, Anthony Cappadona, Jean-Paul Bryant, Vibhu Chandrashekhar, Jessa M. Tunacao, Danielle R. Donahue, Jeeva P. Munasinghe, James G. Smirniotopoulos, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
We recently described a transtentorial venous system (TTVS), which to our knowledge was previously unknown, connecting venous drainage throughout the brain in humans. Prior to this finding, it was believed that the embryologic tentorial plexus regres
Externí odkaz:
https://doaj.org/article/46cce3d79ee9495b897955b0b09be5fb
Autor:
Jean-Paul Bryant, Vikram Chandrashekhar, Anthony J. Cappadona, Pashayar P. Lookian, Vibhu Chandrashekhar, Danielle R. Donahue, Jeeva B. Munasinghe, H. Jeffrey Kim, Alexander O. Vortmeyer, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves. Development of this structure from neural crest beg
Externí odkaz:
https://doaj.org/article/8e0e50e78d7248fd90cfb3fe0597bb72
Publikováno v:
Cancers, Vol 14, Iss 9, p 2285 (2022)
Pediatric medulloblastoma (MB) is the most common pediatric brain tumor with varying prognoses depending on the distinct molecular subtype. The four consensus subgroups are WNT, Sonic hedgehog (SHH), Group 3, and Group 4, which underpin the current 2
Externí odkaz:
https://doaj.org/article/fcb2b4dcbb534a67b2a973c6c8a1deee
Autor:
Jared S. Rosenblum, Herui Wang, Pauline M. Dmitriev, Anthony J. Cappadona, Panagiotis Mastorakos, Chen Xu, Abhishek Jha, Nancy Edwards, Danielle R. Donahue, Jeeva Munasinghe, Matthew A. Nazari, Russell H. Knutsen, Bruce R. Rosenblum, James G. Smirniotopoulos, Alberto Pappo, Robert F. Spetzler, Alexander Vortmeyer, Mark R. Gilbert, Dorian B. McGavern, Emily Chew, Beth A. Kozel, John D. Heiss, Zhengping Zhuang, Karel Pacak
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Mutations in EPAS1, encoding hypoxia-inducible factor-2α (HIF-2α), were previously identified in a syndrome of multiple paragangliomas, somatostatinoma, and polycythemia. HIF-2α, when dimerized with HIF-1β, acts as an angiogenic transcription fac
Externí odkaz:
https://doaj.org/article/13982532d1b84ab7917970578fa07532