Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification

Autor: Uma Mahesh R. Avula, Lea Melki, Jared S. Kushner, Stephanie Liang, Elaine Y. Wan

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Reentrant cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF) are common cardiac arrhythmias that account for substantial morbidity and mortality throughout the world. However, the mechanisms and optimal ablation tr

Externí odkaz: https://doaj.org/article/bc2607a4535e4db495b844bb4d5b098f

Rad regulation of Ca

Autor: Arianne, Papa, Sergey I, Zakharov, Alexander N, Katchman, Jared S, Kushner, Bi-Xing, Chen, Lin, Yang, Guoxia, Liu, Alejandro Sanchez, Jimenez, Robyn J, Eisert, Gary A, Bradshaw, Wen, Dun, Shah R, Ali, Aaron, Rodriques, Karen, Zhou, Veli, Topkara, Mu, Yang, John P, Morrow, Emily J, Tsai, Arthur, Karlin, Elaine, Wan, Marian, Kalocsay, Geoffrey S, Pitt, Henry M, Colecraft, Manu, Ben-Johny, Steven O, Marx

Publikováno v: Nature cardiovascular research. 1(11)

Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart's innate contractile reserve. We show that four protein kinase A (PKA)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::098eb2ff6d51588c62d0ba69760229f2
https://pubmed.ncbi.nlm.nih.gov/36424916

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

Autor: Till Milde, Sergey V. Shmelkov, Andrew J. Murphy, Kevin G. Bath, Muhamed Baljevic, David M. Valenzuela, Francis S. Lee, Nicholas W. Gale, Evgeny Shmelkov, Deqiang Jing, Ipe Ninan, Jared S Kushner, George D. Yancopoulos, Iva Dincheva, Adilia Hormigo, Shahin Rafii, Catia C. Proenca

Publikováno v: Nature Medicine. 16:598-602

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions, and it often encompasses anxiety and depressive symptoms1,2. Recently, the corticostriatal circuitry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1c792c2332bb6b390a12c48c310a49
https://doi.org/10.1038/nm.2125

Rad regulation of Ca V 1.2 channels controls cardiac fight-or-flight response.

Autor: Papa A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Zakharov SI; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Katchman AN; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Kushner JS; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; These authors contributed equally: Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner., Chen BX; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Yang L; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Liu G; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Jimenez AS; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Eisert RJ; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Bradshaw GA; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Dun W; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Ali SR; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Rodriques A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Zhou K; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Topkara V; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Yang M; Institute for Genomic Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Morrow JP; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Tsai EJ; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Karlin A; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA., Wan E; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Kalocsay M; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Present address: Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pitt GS; Cardiovascular Research Institute and Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Colecraft HM; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology and Molecular Signaling, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA., Marx SO; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology and Molecular Signaling, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Nov; Vol. 1 (11), pp. 1022-1038. Date of Electronic Publication: 2022 Nov 14.