Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jared M. Churko"'
Autor:
Rinku S. Skaria, Marissa A. Lopez‐Pier, Brij S. Kathuria, Christian J. Leber, Paul R. Langlais, Shravan G. Aras, Zain I. Khalpey, Pamela G. Hitscherich, Evangelia Chnari, Marc Long, Jared M. Churko, Raymond B. Runyan, John P. Konhilas
Publikováno v:
Physiological Reports, Vol 11, Iss 20, Pp n/a-n/a (2023)
Abstract Cardiac ischemic reperfusion injury (IRI) is paradoxically instigated by reestablishing blood‐flow to ischemic myocardium typically from a myocardial infarction (MI). Although revascularization following MI remains the standard of care, ef
Externí odkaz:
https://doaj.org/article/1914eda30e2946a1b3561fc74669f95e
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102944- (2022)
Pontocerebellar Hypoplasia 1B (PCH1B) is a severe autosomal recessive neurological disorder that is associated with mutations in the exosome complex component RRP40 (EXOSC3) gene. We generated and characterized an iPSC line from an individual with PC
Externí odkaz:
https://doaj.org/article/93233c957353401b8db66d295f7fa7eb
Autor:
Jayati Chakrabarti, Ritu Pandey, Jared M. Churko, Jennifer Eschbacher, Saptarshi Mallick, Yuliang Chen, Beth Hermes, Palash Mallick, Ben N. Stansfield, Kelvin W. Pond, Curtis A. Thorne, Kevin C. J. Yuen, Andrew S. Little, Yana Zavros
Publikováno v:
Cells, Vol 11, Iss 21, p 3344 (2022)
(1) Background: Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to
Externí odkaz:
https://doaj.org/article/654d70ac56184aceb382ca726ba56b25
Autor:
Jared M. Churko, Priyanka Garg, Barbara Treutlein, Meenakshi Venkatasubramanian, Haodi Wu, Jaecheol Lee, Quinton N. Wessells, Shih-Yu Chen, Wen-Yi Chen, Kashish Chetal, Gary Mantalas, Norma Neff, Eric Jabart, Arun Sharma, Garry P. Nolan, Nathan Salomonis, Joseph C. Wu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Human induced pluripotent stem cell derived cardiomyocytes are a powerful model for cardiogenesis and disease in vitro. Here the authors comprehensively map cardiac differentiation using multiple modalities, including single-cell RNA seq and CyTOF, i
Externí odkaz:
https://doaj.org/article/2ddb8b7790bb4652b885d858f26957c7
Autor:
Linda Berg Luecke, Matthew Waas, Jack Littrell, Melinda Wojtkiewicz, Chase Castro, Maria Burkovetskaya, Erin N. Schuette, Amanda Rae Buchberger, Jared M. Churko, Upendra Chalise, Michelle Waknitz, Shelby Konfrst, Roald Teuben, Justin Morrissette-McAlmon, Claudius Mahr, Daniel R. Anderson, Kenneth R. Boheler, Rebekah L. Gundry
Publikováno v:
Nature Cardiovascular Research. 2:76-95
Cardiac cell surface proteins are drug targets and useful biomarkers for discriminating among cellular phenotypes and disease states. Here we developed an analytical platform, CellSurfer, that enables quantitative cell surface proteome (surfaceome) p
Publikováno v:
Tissue Engineering Part B: Reviews. 28:891-911
Recent developments in applied developmental physiology have provided well-defined methodologies for producing human stem cell derived cardiomyocytes. The cardiomyocytes produced have become commonplace as cardiac physiology research models. Accessib
Autor:
Kate Huang, Mishal Ashraf, Leili Rohani, Yinhan Luo, Ardin Sacayanan, Haojun Huang, Anne Haegert, Stanislav Volik, Funda Sar, Stéphane LeBihan, Janet Liew, Jason D. Roberts, Glen F. Tibbits, Jared M. Churko, Shubhayan Sanatani, Colin Collins, Liam R. Brunham, Zachary W. Laksman
BackgroundProtein truncating mutations in the titin gene are associated with increased risk of atrial fibrillation (AF). However, little is known regarding the underlying pathophysiology.MethodsWe identified a heterozygous titin truncating variant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e683910296e17cbec11da9f3984e918c
https://doi.org/10.1101/2023.03.02.530843
https://doi.org/10.1101/2023.03.02.530843
Autor:
Michaela Yuen, Lisa Worgan, Jessika Iwanski, Christopher T. Pappas, Himanshu Joshi, Jared M. Churko, Susan Arbuckle, Edwin P. Kirk, Ying Zhu, Tony Roscioli, Carol C. Gregorio, Sandra T. Cooper
Publikováno v:
European journal of human genetics : EJHG. 30(4)
Dilated cardiomyopathy (DCM) is characterized by cardiac enlargement and impaired ventricular contractility leading to heart failure. A single report identified variants in leiomodin-2 (LMOD2) as a cause of neonatally-lethal DCM. Here, we describe tw
Autor:
John P. Konhilas, Jennifer L. Uhrlaub, Carol C. Gregorio, Samantha Perez-Miller, Samuel K. Campos, Janko Nikolich-Žugich, Jessika Iwanski, Tori T. Salem, Scott D. Lick, Jared M. Churko, Ben Stansfield, Lipsa Jena, Sobhi G. Kazmouz, May Khanna, Shuaizhi Li, Toshinobu Kazui
Publikováno v:
Stem Cell Reports
The pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily speculated that a
Autor:
Tony Chour, Mohamed Ameen, Howard Y. Chang, June-Wha Rhee, Xingqi Chen, Chi Keung Lam, Michael Snyder, Edward Lau, Timon Seeger, Paul J. Wang, Ioannis Karakikes, Joseph C. Wu, Sebastian Diecke, Isaac Perea Gil, Haodi Wu, Karim Sallam, Jared M. Churko, Vittavat Termglinchan, Ilanit Itzhaki, Jae Cheol Lee, Rinkal Chaudhary, Joe Z. Zhang, Matthew Greenhaw, Priyanka Garg
Publikováno v:
Nature. 572:335-340
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Her