Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jared M Cregg"'
Autor:
Alicia N Vagnozzi, Kiran Garg, Carola Dewitz, Matthew T Moore, Jared M Cregg, Lucie Jeannotte, Niccolò Zampieri, Lynn T Landmesser, Polyxeni Philippidou
Publikováno v:
eLife, Vol 9 (2020)
The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown. Phrenic MNs integrate multiple inputs to me
Externí odkaz:
https://doaj.org/article/8012e740220a4b9193c80bdb0b4cac01
Autor:
Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mo
Externí odkaz:
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury
Autor:
Jared M. Cregg, Kevin A. Chu, Lydia E. Hager, Rachel S.J. Maggard, Daimen R. Stoltz, Michaela Edmond, Warren J. Alilain, Polyxeni Philippidou, Lynn T. Landmesser, Jerry Silver
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 654-665 (2017)
Spinal cord injury (SCI) above cervical level 4 disrupts descending axons from the medulla that innervate phrenic motor neurons, causing permanent paralysis of the diaphragm. Using an ex vivo preparation in neonatal mice, we have identified an excita
Externí odkaz:
https://doaj.org/article/994ec695c1454270848206c7b3bfa16f
Autor:
Carola Dewitz, Matthew T Moore, Lynn T. Landmesser, Niccolò Zampieri, Jared M. Cregg, Polyxeni Philippidou, Lucie Jeannotte, Alicia N Vagnozzi, Kiran Garg
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown. Phrenic MNs integrate multiple inputs to me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c7af20d117c859c1c323c39442a02e
https://doi.org/10.7554/elife.52859
https://doi.org/10.7554/elife.52859
Autor:
Jared M. Cregg, Matthew T Moore, Niccolò Zampieri, Polyxeni Philippidou, Alicia N Vagnozzi, Carola Dewitz, Kiran Garg, Lynn T. Landmesser, Lucie Jeannotte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b386843015ea2d7271f6348a7728306a
https://doi.org/10.7554/elife.52859.sa2
https://doi.org/10.7554/elife.52859.sa2
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12815-12820
Central neural networks operate continuously throughout life to control respiration, yet mechanisms regulating ventilatory frequency are poorly understood. Inspiration is generated by the pre-Botzinger complex of the ventrolateral medulla, where it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516246210666e7bd18c37a7a7d457a65
https://doi.org/10.1073/pnas.1711536114
https://doi.org/10.1073/pnas.1711536114
Descending command neurons instruct spinal networks to execute basic locomotor functions, such as which gait and what speed. The command functions for gait and speed are symmetric, implying that a separate unknown system directs asymmetric movements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1720f848a42e6a37c42dead1bac28f40
https://doi.org/10.1101/754812
https://doi.org/10.1101/754812
Autor:
Jared M. Cregg, Madeline A. Howarth, Richard E. Zigmond, Alicia DeFrancesco-Lisowitz, Jon P. Niemi
Publikováno v:
Experimental Neurology. 275:25-37
Neuroinflammation plays a critical role in the regeneration of peripheral nerves following axotomy. An injury to the sciatic nerve leads to significant macrophage accumulation in the L5 DRG, an effect not seen when the dorsal root is injured. We rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d64f93b29000c5f025fc6d3bf03e456
https://doi.org/10.1016/j.expneurol.2015.09.018
https://doi.org/10.1016/j.expneurol.2015.09.018
Autor:
Jared M. Cregg, Benjamin L.L. Clayton, Olivia Corradin, Angela M. Lager, Mayur Madhavan, H. Elizabeth Shick, Kevin C. Allan, Paul J. Tesar, Hannah E. Olsen, Matthew S. Elitt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba808321f8673eb923826fd9adceee21
https://doi.org/10.1038/s41467-018-06102-7
https://doi.org/10.1038/s41467-018-06102-7
Autor:
Cregg, Jared M., Cregg
A fundamental goal in systems neuroscience is to understand how behaviors are executed by the nervous system. Respiration is an essential behavior which we perform hundreds of millions of times over our lifespan. Given that deficits in respiration un