Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jared L. Johnson"'
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113535- (2023)
Summary: The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found that the Hippo ki
Externí odkaz:
https://doaj.org/article/a5e7df93b0a7464587f421f871a959bf
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Boris Bonaventure, Andrew P. Kurland, Chengjin Ye, Tomer M. Yaron, Jared L. Johnson, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martínez-Sobrido, Benjamin tenOever, Jeffrey R. Johnson
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, drastically modifies infected cells to optimize virus replication. One such modification is the activation
Externí odkaz:
https://doaj.org/article/f4d8484e81a64893a39af20ce68f7785
Autor:
Thomas Robert, Jared L. Johnson, Roxane Guichaoua, Tomer M. Yaron, Stéphane Bach, Lewis C. Cantley, Pierre Colas
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Cyclin-dependent kinases (CDKs) constitute a family of 20 serine/threonine protein kinases that play pivotal roles in the regulation of numerous important molecular and cellular processes. CDKs have long been considered promising therapeutic targets
Externí odkaz:
https://doaj.org/article/035492ef7e2b4e65b050f4fe659638a0
Autor:
Ho-Soo Lee, Zhonghui Lin, Sunyoung Chae, Young-Suk Yoo, Byung-Gyu Kim, Youngsoo Lee, Jared L. Johnson, You-Sun Kim, Lewis C. Cantley, Chang-Woo Lee, Hongtao Yu, Hyeseong Cho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The chromatin remodeler RSF1 is enriched at mitotic centromeres but its function there is poorly understood. Here, the authors show that RSF1 regulates H2A phosphorylation and acetylation at mitotic centromeres and contributes to chromosome stability
Externí odkaz:
https://doaj.org/article/0bf89570019f4e5fb76ec6c3b0d31610
Autor:
Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Publikováno v:
Nature. 617:147-153
Pancreatic ductal adenocarcinoma (PDA) is characterized by aggressive local invasion and metastatic spread, leading to high lethality. Although driver gene mutations during PDA progression are conserved, no specific mutation is correlated with the di
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Publikováno v:
Nature. 613:759-766
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and se
Autor:
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V. Vinogradova, Tomer M. Yaron, Evanna L. Mills, Haopeng Xiao, Kristine Senkane, Emily M. Huntsman, Jared L. Johnson, Jianwei Che, Lewis C. Cantley, Benjamin F. Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S. Gray, Edward T. Chouchani
Publikováno v:
Nature Chemical Biology.
Autor:
Tomer M. Yaron, Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M. Liberatore, Danielle K. Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa N. Mercadante, Kripa Shobana-Ganesh, Long He, Robert E. Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, Cait E. Hamele, Ryan R. Chaparian, Alfred T. Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M. Smith, Anthony P. Possemato, Sasha L. Tkachev, Peter V. Hornbeck, Sean A. Beausoleil, Shankara K. Anand, François Aguet, Gad Getz, Andrew D. Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A. Matthews, Benjamin R. tenOever, Lewis C. Cantley, John Blenis, Nicholas S. Heaton
Publikováno v:
Science signaling, vol 15, iss 757
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f52febef82f67d02ed9c0d55e48f84
https://escholarship.org/uc/item/44d513nc
https://escholarship.org/uc/item/44d513nc
Autor:
Ting-Yu Lin, Shakti Ramsamooj, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves
SUMMARYThe phosphoinositide 3-kinase, p110α, is an essential mediator of insulin signaling and glucose homeostasis. We systematically interrogated the human serine, threonine, and tyrosine kinome to search for novel regulators of p110α and found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ba4d436ebb86a27446a3658dea59f6
https://doi.org/10.1101/2022.07.19.500601
https://doi.org/10.1101/2022.07.19.500601