Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jared L. Clever"'
Autor:
Jared L Clever, Saipiroon M Tam, Victor Lira, Victor Martin, EstherFatehi, Subhagya Wadekar, Sateesh Apte, Koen Ka Van Rompay, Audrey M. Gutierrez
Publikováno v:
Journal of HIV & Retro Virus.
The effect of a live nef-deleted SIVmac 239 construct (SIVΔ nef) was evaluated in rhesus macaques infected with wild-type SIVmac 239 . Rhesus macaques were inoculated by intravenous administration of 100 tissue culture infectious doses 50% (TCID 50
Autor:
Stanley B. Prusiner, Essia Bouzamondo-Bernstein, Jared L. Clever, Erik Samayoa, Eric J. Huang, Nako Ishikura, Stephen J. DeArmond
Publikováno v:
Proceedings of the National Academy of Sciences. 102:886-891
In addition to neuronal vacuolation and astrocytic hypertrophy, dendritic atrophy is a prominent feature of prion disease. Because increased Notch-1 expression and cleavage releasing its intracellular domain (NICD) inhibit both dendrite growth and ma
Publikováno v:
Journal of Virology. 74:541-546
Retroviral RNA encapsidation depends on the specific binding of Gag proteins to packaging (ψ) signals in genomic RNA. We investigated whether an in vitro-selected, high-affinity RNA ligand for the nucleocapsid (NC) portion of the Gag protein from hu
Publikováno v:
Journal of Virology. 73:101-109
The efficient packaging of genomic RNA into virions of human immunodeficiency virus type 1 (HIV-1) is directed by cis -acting encapsidation signals, which have been mapped to particular RNA stem-loop structures near the 5′ end of the genome. Earlie
Publikováno v:
Nature Structural Biology. 5:432-436
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stab
Autor:
Sheela Waugh, Jared L. Clever, Tristram G. Parslow, Michael A. Lochrie, Barry Polisky, Dickson G. Pratt
Publikováno v:
Nucleic Acids Research. 25:2902-2910
RNA ligands that bind to the human immunodeficiency virus type-1 (HIV-1) gag polyprotein with 10(-9) M affinity were isolated from a complex pool of RNAs using an in vitro selection method. The ligands bind to two different regions within gag, either
Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation
Autor:
Jared L. Clever, Tristram G. Parslow
Publikováno v:
Journal of Virology. 71:3407-3414
Retrovirus particles each contain two copies of the viral genome in the form of a noncovalently linked RNA dimer. Earlier studies have mapped a cis-acting region near the 5' end of the human immunodeficiency virus type 1 (HIV-1) genome, termed the ps
Publikováno v:
Journal of Virology. 69:2101-2109
The selective encapsidation of retroviral RNA requires sequences in the Gag protein, as well as a cis-acting RNA packaging signal (psi site) near the 5' end of the genomic transcript. Gag protein of human immunodeficiency virus type 1 (HIV-1) has rec
Autor:
Tristram G. Parslow, Andrew C. Chan, Thomas J. Hope, Melissa E. Elder, Dong Lin, Arthur Weiss, Jared L. Clever
Publikováno v:
Science. 264:1596-1599
A homozygous mutation in the kinase domain of ZAP-70, a T cell receptor-associated protein tyrosine kinase, produced a distinctive form of human severe combined immunodeficiency. Manifestations of this disorder included profound immunodeficiency, abs
Publikováno v:
American journal of physiology. Cell physiology. 298(5)
The bone morphogenetic protein (BMP) pathway is known to be involved in limb myogenesis during development, but whether it is involved in postnatal muscle regeneration is unclear. We have found that adult inhibitor of differentiation (Id)-mutant (Id1