Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jared J. Hartsock"'
Autor:
Jared J. Hartsock, Nils Prenzler, Christina L. Runge, Thomas Lenarz, Will Mclean, Jeffrey S. Rosenbloom, Ashley S. Hinton, Steven D. Rauch, René H. Gifford, George Atiee, Alec N. Salt, Susan King, Sam Wilson, Moraye Bear, Jeffrey M. Karp, Christopher R. Loose, Jenna T.J. Herby, Carl Lebel, David L. Lucchino, Lance E. Jackson, Daniel J. Lee, Robert Langer, Athanasia Warnecke, H Schmitt
Publikováno v:
Otology & Neurotology
Objectives There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been shown to regenerate mammalian cochlear hair cells ex vivo. The objectives were to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03811253e2a9a6476058ba969ed7f98d
http://europepmc.org/articles/PMC8279894
http://europepmc.org/articles/PMC8279894
Publikováno v:
Neuromethods ISBN: 9781071620212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1fb27c86096c3f5c0fcc5e214a2e889
https://doi.org/10.1007/978-1-0716-2022-9_12
https://doi.org/10.1007/978-1-0716-2022-9_12
Autor:
Choongheon Lee, Alec N. Salt, Mark A. Rutherford, Shawn S. Goodman, Jared J. Hartsock, Amit Walia, Roland E. Dolle, Jeffery T. Lichtenhan
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and Ca2+ perme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494d97236bcc999c367c83edde1afb78
https://www.frontiersin.org/articles/10.3389/fnsyn.2021.680621/full
https://www.frontiersin.org/articles/10.3389/fnsyn.2021.680621/full
Publikováno v:
Otology & Neurotology. 39:639-647
Measurements of perilymph concentration achieved after intratympanic (IT) drug applications typically find the perilymph concentration to be substantially lower than the applied concentration. Following IT steroid applications in guinea pigs, perilym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de356ceef1cb19055787a7b31b2c105
https://doi.org/10.1097/mao.0000000000001786
https://doi.org/10.1097/mao.0000000000001786
Publikováno v:
Audiology and Neurotology. 23:245-257
Dexamethasone phosphate is widely used for intratympanic therapy in humans. We assessed the pharmacokinetics of dexamethasone entry into perilymph when administered as a dexamethasone phosphate solution or as a micronized dexamethasone suspension, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44707f96cca76c99d3cc020e77ef3c51
https://doi.org/10.1159/000493846
https://doi.org/10.1159/000493846
Autor:
Robert Voss, Alec N. Salt, Cong Tian, Kenneth R. Johnson, Kevin K. Ohlemiller, Jared J. Hartsock, Jaclynn M. Lett, Peter S. Steyger
Publikováno v:
Hear Res
CACHD1 recently was shown to be an α2δ-like subunit that can modulate the activity of some types of voltage-gated calcium channels, including the low-voltage activated, T-type Ca(v)3 channels. CACHD1 is widely expressed in the central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d9e4bbaff1c3f613fca1d91d9ee2c3
https://doi.org/10.1016/j.heares.2021.108327
https://doi.org/10.1016/j.heares.2021.108327
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f398a984aa77b4389d7d6bf44827634
https://www.frontiersin.org/article/10.3389/fncel.2019.00347/full
https://www.frontiersin.org/article/10.3389/fncel.2019.00347/full
Publikováno v:
Audiology and Neurotology. 21:72-79
The goal of this study was to develop an appropriate methodology to apply drugs quantitatively to the perilymph of the ear. Intratympanic applications of drugs to the inner ear often result in variable drug levels in the perilymph and can only be use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5705181a0528a0de9a79680829fa5084
https://doi.org/10.1159/000442514
https://doi.org/10.1159/000442514
Autor:
Ruth M. Gill, Alec N. Salt, Kristien Verhoeven, Jared J. Hartsock, Daniel Smyth, Jonathon Kirk
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0183374 (2017)
PLoS ONE, Vol 12, Iss 8, p e0183374 (2017)
Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations. One way to apply drugs is to incorporate a cannula in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f622ae16c5c433222a5fe98bd2eb7333
https://pubmed.ncbi.nlm.nih.gov/28817653
https://pubmed.ncbi.nlm.nih.gov/28817653
Publikováno v:
Journal of the Association for Research in Otolaryngology. 15:707-719
The blood vessels that supply the inner ear form a barrier between the blood and the inner ear fluids to control the exchange of solutes, protein, and water. This barrier, called the blood-labyrinth barrier (BLB) is analogous to the blood-brain barri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec29f8316a08535658c126825ed4a15
https://doi.org/10.1007/s10162-014-0476-6
https://doi.org/10.1007/s10162-014-0476-6