Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jared E. Lopes"'
Autor:
Lukas W Pfannenstiel, Brian R Gastman, Jennifer S Ko, Marc S Ernstoff, Pauline Funchain, Yee Peng Phoon, Jared E Lopes, Heather C Losey, Claudia Marcela Diaz-Montero, Ye F Tian, Raymond Winquist, Jan Joseph Melenhorst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Despite recent advances in immunotherapy, a substantial population of late-stage melanoma patients still fail to achieve sustained clinical benefit. Lack of translational preclinical models continues to be a major challenge in the field of
Externí odkaz:
https://doaj.org/article/be91f26ce0d14a72a9d770e7782a5e38
Autor:
Jared E Lopes, Anje Cauwels, Niko Kley, Lennart Zabeau, Alexander Van Parys, Sylvie Taveirne, Erik Depla
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/475be55bc8db427ebeed963bf99410c1
Autor:
Hua Zhang, Ting Chen, Vamsidhar Velcheti, Kwok-Kin Wong, Jared E Lopes, Heather C Losey, Elaine Shum, Han Han, Hai Hu, Yuanwang Pan, Yuan Hao, Hailin Ding, Kristen E Labbe, Kayla Guidry, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Raymond J Winquist
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Small cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highli
Externí odkaz:
https://doaj.org/article/5f4845cac4494148a2dafe15454c9d88
Autor:
Marc S Ernstoff, Jan L Fisher, Jared E Lopes, Heather L Flick, Chunhua Wang, Lei Sun, Juan C Alvarez, Heather C Losey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Interleukin-2 (IL-2) plays a pivotal role in immune homeostasis due to its ability to stimulate numerous lymphocyte subsets including natural killer (NK) cells, effector CD4+ and CD8+ T cells, and regulatory T cells (Tregs). Low concentrat
Externí odkaz:
https://doaj.org/article/45f0eb598bd6444ebc023bb0ce491ca9
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:203-210
Nemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel cytokine created by the fusion of circularly permuted interleukin-2 (IL-2) to the IL-2Rα subunit of the IL-2 receptor (IL-2R) complex that confers selectivity for the intermediate-affinity IL-2R e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b501d2d3f4ee59904207fb6219c8c2a
https://doi.org/10.1124/jpet.121.000612
https://doi.org/10.1124/jpet.121.000612
Autor:
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E Lopes, Heather C Losey, Raymond J Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong
Publikováno v:
Journal for immunotherapy of cancer. 10(9)
BackgroundSmall cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highlig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066777967055bb157d69269f541db5b
https://pubmed.ncbi.nlm.nih.gov/36472839
https://pubmed.ncbi.nlm.nih.gov/36472839
Autor:
Yee Peng Phoon, Jared E. Lopes, Lukas W. Pfannenstiel, C. Marcela Diaz-Montero, Ye F. Tian, Marc S. Ernstoff, Pauline Funchain, XiaoXia Li, Heather C. Losey, Raymond J. Winquist, Brian R. Gastman
Publikováno v:
Cancer Research. 83:1818-1818
Introduction: The development and FDA approval of drugs targeting the PD-1/PD-L1 axis has greatly shifted the paradigm of immunotherapy and has improved the clinical outcome for patients diagnosed with advanced melanoma. Despite the recent advancemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69baa6a476e073733a257791a114a416
https://doi.org/10.1158/1538-7445.am2023-1818
https://doi.org/10.1158/1538-7445.am2023-1818
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::6c9f64ea594454da097f3cbf41303f9f
https://jitc.bmj.com/content/8/1/e000157corr1.full
https://jitc.bmj.com/content/8/1/e000157corr1.full
Autor:
Ulka N. Vaishampayan, Shipra Gandhi, Seth David Rosen, Anna Spreafico, Debora S. Bruno, Quincy S. Chu, Aman Chauhan, Olivier Dumas, Hal W. Hirte, Jared E. Lopes, Heather Losey, Yan Wang, Lei Sun, Monali Bhardwaj Desai, Rita P. Dalal, Yangchun Du, Julie R. Graham, Jameel Muzaffar, Ira Seth Winer
Publikováno v:
Journal of Clinical Oncology. 40:659-659
659 Background: Nemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel engineered cytokine that selectively binds to the intermediate-affinity IL-2 receptor, preferentially activating and expanding antitumor CD8+ T and NK cells, with minimal expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea5161a3a47fef34b15c6f663931f2b
https://doi.org/10.1200/jco.2022.40.4_suppl.659
https://doi.org/10.1200/jco.2022.40.4_suppl.659
Autor:
Yuanwang Pan, Ting Chen, H.C. Losey, S. Nguyen, Raymond J. Winquist, H. Ding, C. Almonte, K.E. Labbe, H. Han, Hua Zhang, K-K. Wong, Jared E. Lopes
Publikováno v:
Annals of Oncology. 32:S1169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4255e40fc55153dfbc5f89cf927d9ceb
https://doi.org/10.1016/j.annonc.2021.08.245
https://doi.org/10.1016/j.annonc.2021.08.245