Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Jared E Toettcher"'
Autor:
Payam E Farahani, Xiaoyu Yang, Emily V Mesev, Kaylan A Fomby, Ellen H Brumbaugh-Reed, Caleb J Bashor, Celeste M Nelson, Jared E Toettcher
Publikováno v:
eLife, Vol 12 (2023)
Receptor tyrosine kinases (RTKs) are major signaling hubs in metazoans, playing crucial roles in cell proliferation, migration, and differentiation. However, few tools are available to measure the activity of a specific RTK in individual living cells
Externí odkaz:
https://doaj.org/article/d80e6707678348058feb76df9128ca69
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Biomolecular condensates are broadly implicated in both normal cellular regulation and disease. Consequently, several chemical biology and optogenetic approaches have been developed to induce phase separation of a protein of interest. Howeve
Externí odkaz:
https://doaj.org/article/2734a9f4aa924704ae35e1798669302a
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209301 (2018)
Cell populations across nearly all forms of life generally maintain a characteristic cell type-dependent size, but how size control is achieved has been a long-standing question. The G1/S boundary of the cell cycle serves as a major point of size con
Externí odkaz:
https://doaj.org/article/8d42d3a706ac48ea9bbf7fa026b54991
Autor:
Oliver Hoeller, Jared E Toettcher, Huaqing Cai, Yaohui Sun, Chuan-Hsiang Huang, Mariel Freyre, Min Zhao, Peter N Devreotes, Orion D Weiner
Publikováno v:
PLoS Biology, Vol 14, Iss 2, p e1002381 (2016)
For directional movement, eukaryotic cells depend on the proper organization of their actin cytoskeleton. This engine of motility is made up of highly dynamic nonequilibrium actin structures such as flashes, oscillations, and traveling waves. In Dict
Externí odkaz:
https://doaj.org/article/734dfa607efc4143957f29db080a679a
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 2, p e30 (2008)
Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. One challenge in model d
Externí odkaz:
https://doaj.org/article/fab8e059031a4b60914c1ca14447329d
Autor:
Anand P. Singh, Ping Wu, Sergey Ryabichko, João Raimundo, Michael Swan, Eric Wieschaus, Thomas Gregor, Jared E. Toettcher
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110543- (2022)
Summary: Developmental patterning networks are regulated by multiple inputs and feedback connections that rapidly reshape gene expression, limiting the information that can be gained solely from slow genetic perturbations. Here we show that fast opto
Externí odkaz:
https://doaj.org/article/d5a1f8deb97843fc8a767a3c1820c519
Autor:
Payam E Farahani, Xiaoyu Yang, Emily V Mesev, Kaylan A Fomby, Ellen H Brumbaugh-Reed, Caleb J Bashor, Celeste M Nelson, Jared E Toettcher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f8bb5a397cac25bdd0ff67b47d7d5c
https://doi.org/10.7554/elife.82863.sa2
https://doi.org/10.7554/elife.82863.sa2
Autor:
Emily K. Ho, Harrison R. Oatman, Sarah E. McFann, Liu Yang, Heath E. Johnson, Stanislav Y. Shvartsman, Jared E. Toettcher
Positional information in developing tissues often takes the form of stripes of gene expression that mark the boundaries of a particular cell type or morphogenetic process. How stripes form is still in many cases poorly understood. Here we use optoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9527b17962c611e710641234cb83ce8f
https://doi.org/10.1101/2023.03.09.531972
https://doi.org/10.1101/2023.03.09.531972
Autor:
Evan J. Underhill, Jared E. Toettcher
Fibroblast growth factor (FGF) dependent elongation along an anterior-posterior (A-P) axis is a conserved feature of vertebrate embryogenesis. A-P axis elongation can also be reproduced in 3D cell culture models termed gastruloids, enabling dissectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb9c0628cdb792ec3249bdd82eedb0f
https://doi.org/10.1101/2023.01.27.525895
https://doi.org/10.1101/2023.01.27.525895
Publikováno v:
Annual Review of Biomedical Engineering. 23:61-87
Cells receive enormous amounts of information from their environment. How they act on this information—by migrating, expressing genes, or relaying signals to other cells—comprises much of the regulatory and self-organizational complexity found ac