Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jared D. Hoffman"'
Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice
Autor:
Lucille M. Yanckello, Lyndsay E. A. Young, Jared D. Hoffman, Robert P. Mohney, Mignon A. Keaton, Erin Abner, Ai-Ling Lin
Publikováno v:
Frontiers in Nutrition, Vol 6 (2019)
Caloric restriction (CR) has been shown to extend longevity and protect brain function in aging. However, the effects of CR in young adult mice remain largely unexplored. In addition to the fundamental, long-term changes, recent studies demonstrate t
Externí odkaz:
https://doaj.org/article/60c0b33376b64bbcb93538a33333c88f
Autor:
Jennifer Lee, Lucille M. Yanckello, David Ma, Jared D. Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M. S. Hartz, Fahmeed Hyder, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that include rapamycin and caloric restriction (CR).
Externí odkaz:
https://doaj.org/article/8a74dc9b9c6340bfb5d737225ecefe53
Autor:
Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain met
Externí odkaz:
https://doaj.org/article/bb227085d55c400fbb159dda0c3c7eff
Autor:
Lucille M. Yanckello, Stefan J. Green, George E. Chlipala, Penghui Lin, Anika M.S. Hartz, Andrew T. Yackzan, Scott McCulloch, Ya-Hsuan Chang, Andrew N. Lane, Tyler C. Hammond, Ai-Ling Lin, Geetika Nehra, Jared D. Hoffman
Publikováno v:
Nutritional Neuroscience. 25:1669-1679
The goal of the study was to identify the potential nutrigenetic effects to inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants. Specifically, we compared responses to inulin for the potential modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aaea5c4b10e59ae230160d0c915c1e
https://doi.org/10.1080/1028415x.2021.1889452
https://doi.org/10.1080/1028415x.2021.1889452
Autor:
Andrew N. Lane, George E. Chlipala, Jared D. Hoffman, Ya-Hsuan Chang, Ai-Ling Lin, Penghui Lin, Stefan J. Green, Lucille M. Yanckello, Scott McCulloch
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7ed19d7c25562a07bc8ece5f36c5da
https://doi.org/10.1002/alz.041175
https://doi.org/10.1002/alz.041175
Autor:
Penghui Lin, Lucille M. Yanckello, Ai-Ling Lin, George E. Chlipala, Scott McCulloch, Stefan J. Green, Andrew N. Lane, Ya-Hsuan Chang, Jared D. Hoffman
Publikováno v:
Curr Dev Nutr
OBJECTIVES: Apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD). Cognitively normal APOE4 carriers show an early decline in brain metabolic functions and gut microbiome dysbiosis before the onset of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b2273ab3f500e6eb01820fa69f844d
https://europepmc.org/articles/PMC7258715/
https://europepmc.org/articles/PMC7258715/
Autor:
Anika M.S. Hartz, M. Paul Murphy, Björn Bauer, David Ma, Amy C Wang, George E. Chlipala, Stefan J. Green, Ishita Parikh, Brent S. Sokola, Jared D. Hoffman, Ai-Ling Lin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major role in determining cognitive capability. Recent studies suggest that neurovascular integrity could be regulated by the gut microbiome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4272a3b2f1915827cd26c16298207aac
http://link.springer.com/article/10.1038/s41598-018-25190-5
http://link.springer.com/article/10.1038/s41598-018-25190-5
Publikováno v:
Current Nutrition Reports. 6:41-48
Non-invasive neuroimaging methods have been developed as powerful tools for identifying in vivo brain functions for studies in humans and animals. Here, we review the imaging biomarkers that are being used to determine the changes within brain metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfc0248f8f6b795cf1f4566a954b712
https://doi.org/10.1007/s13668-017-0187-9
https://doi.org/10.1007/s13668-017-0187-9
Autor:
Brittany N. Turba, Ai-Ling Lin, Lance A. Johnson, Rachel S.J. Maggard, Kyle Ritter, Christopher M. Calulot, Lydia E. Hager, Warren J. Alilain, Jared D. Hoffman
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afaad7f7995edf3a6942ca58a774fe9d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.450.5
https://doi.org/10.1096/fasebj.2019.33.1_supplement.450.5
Autor:
Anika M.S. Hartz, Ishita Parikh, Björn Bauer, Jared D. Hoffman, Ralf G. Rempe, Ai-Ling Lin, Rachel Armstrong, Kai-Hsiang Chuang, Yu Zhong, Janet Guo
Publikováno v:
Aging (Albany NY)
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging and reducing the risk for age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c44db593958bc668fb147742a84b2d6
https://doi.org/10.18632/aging.101094
https://doi.org/10.18632/aging.101094