Výsledky vyhledávání - "Jared A. Sperling"

Autor: Siva SVP Sakamuri, Venkata N Sure, Lahari Kolli, Wesley R Evans, Jared A Sperling, Gregory J Bix, Xiaoying Wang, Dmitriy N Atochin, Walter L Murfee, Ricardo Mostany, Prasad VG Katakam

Publikováno v: J Cereb Blood Flow Metab

Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The goal of our study is to characterize the impact of aging on brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a3cd3c4663c1f8344099494ee62391
https://doi.org/10.1177/0271678x211069266

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Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells

Autor: Siva S. V. P. Sakamuri, Venkata N. Sure, Lahari Kolli, Ning Liu, Wesley R. Evans, Jared A. Sperling, David W. Busija, Xiaoying Wang, Sarah H. Lindsey, Walter L. Murfee, Ricardo Mostany, Prasad V. G. Katakam

Publikováno v: GeroScience

Alterations of mitochondrial and glycolytic energy pathways related to aging could contribute to cerebrovascular dysfunction. We studied the impact of aging on energetics of primary human brain microvascular endothelial cells (HBMECs) by comparing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446ede1af773c39096646ac6b5a3609d
https://europepmc.org/articles/PMC9616994/

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Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria

Autor: Jared A. Sperling, Wesley R. Evans, Siva S.V.P. Sakamuri, Aaron L. Albuck, Ricardo Mostany, Prasad V. G. Katakam, Monica H. Dholakia, Ryousuke Satou, Venkata N. Sure

Publikováno v: Am J Physiol Heart Circ Physiol

Nitric oxide (NO) is known to exert inhibitory control on mitochondrial respiration in the heart and brain. Evidence supports the presence of NO synthase (NOS) in the mitochondria (mtNOS) of cells; however, the functional role of mtNOS in the regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8ac313f9807694bacae8c00ed4bcef
https://doi.org/10.1152/ajpheart.00720.2019

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Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria

Autor: Jared A. Sperling, Ricardo Mostany, Wesley R. Evans, Aaron L. Albuck, Venkata N. Sure, Lahari Kolli, Prasad V. G. Katakam, Siva S.V.P. Sakamuri

Publikováno v: Am J Physiol Heart Circ Physiol

Peroxynitrite (PN), generated from the reaction of nitric oxide (NO) and superoxide, is implicated in the pathogenesis of ischemic and neurodegenerative brain injuries. Mitochondria produce NO from mitochondrial NO synthases and superoxide by the ele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26df3dac4e4b1851d07035589bd16056
https://pubmed.ncbi.nlm.nih.gov/33164581

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A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice

Autor: Jared A. Sperling, Siva S.V.P. Sakamuri, David W. Busija, Wesley R. Evans, Ivan Merdzo, Venkata N. Sure, Prasad V. G. Katakam, Walter L. Murfee, Ricardo Mostany

Publikováno v: GeroScience. 40:365-375

Cerebral blood flow (CBF) is uniquely regulated by the anatomical design of the cerebral vasculature as well as through neurovascular coupling. The process of directing the CBF to meet the energy demands of neuronal activity is referred to as neurova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc373dfaa650742f047ca668a5a9a114
https://doi.org/10.1007/s11357-018-0037-8

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Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research

Autor: Jared A. Sperling, Monica H. Dholakia, Ibolya Rutkai, Padmini S. Mahalingam, Venkata N. Sure, Nicholas R. Peterson, Ryosuke Satou, Siva S.V.P. Sakamuri, Prasad V. G. Katakam

Publikováno v: GeroScience. 40:347-356

Mitochondria play a critical role in the cardiomyocyte physiology by generating majority of the ATP required for the contraction/relaxation through oxidative phosphorylation (OXPHOS). Aging is a major risk factor for cardiovascular diseases (CVD) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a796254b0f6db86d4610d7b2d7e59b48
https://doi.org/10.1007/s11357-018-0021-3

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Measuring Respiration in Isolated Murine Brain Mitochondria: Implications for Mechanistic Stroke Studies

Autor: Ricardo Mostany, Venkata N. Sure, Nicholas R. Peterson, Prasad V. G. Katakam, Wesley R. Evans, Siva S.V.P. Sakamuri, Ibolya Rutkai, Jared A. Sperling, Aaron L. Albuck, Ryousuke Satou

Publikováno v: Neuromolecular Med

Measuring mitochondrial respiration in brain tissue is very critical in understanding the physiology and pathology of the central nervous system. Particularly, measurement of respiration in isolated mitochondria provides the advantage over the whole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601867633e0c0661ab4b9610d757e3f1
https://pubmed.ncbi.nlm.nih.gov/31172441

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