Výsledky vyhledávání - "Jared A. Hammernik"

Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

Autor: Jared A. Hammernik, Marta Marin-Argany, Luis M. Blancas-Mejia, Marina Ramirez-Alvarado

Publikováno v: Journal of Biological Chemistry. 290:4953-4965

Amyloid light chain (AL) amyloidosis is a protein misfolding disease where immunoglobulin light chains sample partially folded states that lead to misfolding and amyloid formation, resulting in organ dysfunction and death. In vivo, amyloid deposits a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b2e9719a341302c97846bf75726b8
https://doi.org/10.1074/jbc.m114.615401

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Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2–lipid bilayer interactions

Autor: Javier L. Baylon, Emad Tajkhorshid, Aditi Das, Yelena V. Grinkova, Jared A. Hammernik, Daryl D. Meling, Daniel R. McDougle, Amogh Kambalyal

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. (10):2460-2470

CYP2J2 epoxygenase is an extrahepatic, membrane bound cytochrome P450 (CYP) that is primarily found in the heart and mediates endogenous fatty acid metabolism. CYP2J2 interacts with membranes through an N-terminal anchor and various non-contiguous hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c728f4945af213046c659b6c27c6bb24

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