Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jared A Delmar"'
Autor:
Hsiang-Ting Lei, Tsung-Han Chou, Chih-Chia Su, Jani Reddy Bolla, Nitin Kumar, Abhijith Radhakrishnan, Feng Long, Jared A Delmar, Sylvia V Do, Kanagalaghatta R Rajashankar, William M Shafer, Edward W Yu
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97475 (2014)
Active efflux of antimicrobial agents is one of the most important strategies used by bacteria to defend against antimicrobial factors present in their environment. Mediating many cases of antibiotic resistance are transmembrane efflux pumps, compose
Externí odkaz:
https://doaj.org/article/554d57ae66394b6cb2734f033b6ee06d
Autor:
Jani Reddy Bolla, Chih-Chia Su, Sylvia V Do, Abhijith Radhakrishnan, Nitin Kumar, Feng Long, Tsung-Han Chou, Jared A Delmar, Hsiang-Ting Lei, Kanagalaghatta R Rajashankar, William M Shafer, Edward W Yu
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97903 (2014)
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains
Externí odkaz:
https://doaj.org/article/34a340589890428cbd269a72a7133032
Autor:
Jared A. Delmar, Eugen Buehler, Ashwin K. Chetty, Agastya Das, Guillermo Miro Quesada, Jihong Wang, Xiaoyu Chen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 466-477 (2021)
Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins. Oxidation impacts all steps of protein production, manufacturi
Externí odkaz:
https://doaj.org/article/5ce2900605144a59996010831a42b91a
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 374- (2020)
Externí odkaz:
https://doaj.org/article/982148afa3674c68bb7b1d80ca42b247
Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder
Autor:
Yeqing Tao, Yuan Chen, Wesley Howard, Mariam Ibrahim, Sajal M. Patel, William P. McMahon, Yoen Joo Kim, Jared A. Delmar, Darryl Davis
Publikováno v:
Pharmaceutical Research.
Background Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug products are closely monit
Autor:
Xiaoyu Chen, Jared A. Delmar, Agastya Das, Eugen Buehler, Guillermo Miro Quesada, Jihong Wang, Ashwin K. Chetty
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 466-477 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins. Oxidation impacts all steps of protein production, manufacturi
Autor:
Jared A. Delmar, Claire Harris, Luigi Grassi, Nathaniel Macapagal, Jihong Wang, Diane Hatton, Weichen Xu
Publikováno v:
Journal of pharmaceutical sciences. 111(11)
During early stage development of a therapeutic IgG1 monoclonal antibody, high levels of low molecular weight (LMW) peaks were observed by high performance size-exclusion chromatography and capillary electrophoresis. Further characterization of the L
Autor:
Rushd Khalaf, Neil Mody, Bruno F. Marques, Steven M. Cramer, Christopher D. Afdahl, Richard C. Willson, Jennifer M. Pollard, Eike Zimmermann, Jan Griesbach, Divya Chandra, Charles A. Haynes, Kannan Sankar, Ujwal Patil, Jonathan Coffman, Hasan Mohammad, Joelle Khouri, Minni Aswath, Jasper C. Lin, Lars Pampel, Alexander Hanke, Siddharth Parimal, David J. Roush, Francis Insaidoo, Saeed Izadi, Raquel Orozco, Soundara Soundararajan, Nihal Tugcu, Gisela Ferreira, Tingting Cui, John P. Welsh, Jainik Panchal, Ambrose Williams, Stefan Hepbildikler, Xuan Hong, Julie Robinson, Marco A. Blanco, John E. Schiel, Jared A. Delmar, Benjamin T. Walters
Publikováno v:
Biotechnology and Bioengineering. 117:2100-2115
Biopharmaceutical product and process development do not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition (mu
Autor:
Yebin Zhou, Shao Huan Samuel Weng, Wen Yu, Dorothy Sims, Junmin Wang, Lisa H. Cazares, Jared A Delmar, Gary P. Sims, Michael A. Bowen, Raghothama Chaerkady, Shivangi Awasthi, Sonja Hess
Publikováno v:
Journal of proteome research. 20(6)
Citrullination is an important post-translational modification implicated in many diseases including rheumatoid arthritis (RA), Alzheimer's disease, and cancer. Neutrophil and mast cells have different expression profiles for protein-arginine deimina
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 374-(2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 264-274 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 264-274 (2019)
The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein degradation and is often seriously disruptive to biological systems. Deamidation has been shown to negatively affe