Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jared, Iacovelli"'
Autor:
Susanna Canali, Alexander W. Fischer, Mychael Nguyen, Karl Anderson, Lorna Wu, Anne-Renee Graham, Chiaowen Joyce Hsiao, Chinmayi Bankar, Nancy Dussault, Veronica Ritchie, Meagan Goodridge, Todd Sparrow, Allison Pannoni, Sze-Wah Tse, Vivienne Woo, Kaitlin Klovdahl, Jared Iacovelli, Eric Huang
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101965- (2024)
Objective: Interleukin (IL)-22 is a potential therapeutic protein for the treatment of metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its involvement in multiple cellular pathw
Externí odkaz:
https://doaj.org/article/1607d00e88f946c5834284e04933fa31
Autor:
Eric Yi-Chun Huang, Clayton Small, William Walker, Tal Zaks, Jared Iacovelli, Kristine Mckinney, Kristen Hopson, Sze-Wah Tse, Mychael Nguyen
Publikováno v:
Molecular Therapy. 29:2227-2238
mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e4ec0b2702e16425dfb445cc1bf7d6
https://doi.org/10.1016/j.ymthe.2021.03.002
https://doi.org/10.1016/j.ymthe.2021.03.002
Autor:
Yaman Lu, Krista L. Namminga, Howard E. Gendelman, Brian T. Wipke, Katherine E. Olson, Eric Huang, Clayton Small, Sze-Wah Tse, Jared Iacovelli, William Walker, Seymour De Picciotto, R. Lee Mosley, Mackenzie J. Thurston, Aaron D. Schwab
Publikováno v:
Biomaterials
Restoring numbers and function of regulatory T cells (Tregs) is a novel therapeutic strategy for neurodegenerative disorders. Whether Treg function is boosted by adoptive cell transfer, pharmaceuticals, or immune modulators, the final result is a rob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916fade2ee7b6c26fd6ef46efa15c50b
https://pubmed.ncbi.nlm.nih.gov/33839625
https://pubmed.ncbi.nlm.nih.gov/33839625
Autor:
Sze-Wah, Tse, Kristine, McKinney, William, Walker, Mychael, Nguyen, Jared, Iacovelli, Clayton, Small, Kristen, Hopson, Tal, Zaks, Eric, Huang
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 29(7)
mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e23022f09bfa23ca0de862cdeb5f9f3
https://pubmed.ncbi.nlm.nih.gov/33677092
https://pubmed.ncbi.nlm.nih.gov/33677092
Publikováno v:
Life Science Alliance
Sustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f827e97611db9c27fe1a48edee9189
https://pubmed.ncbi.nlm.nih.gov/31101737
https://pubmed.ncbi.nlm.nih.gov/31101737
Autor:
Magali Saint-Geniez, Zoltan Arany, Arogya Khadka, Daniel Diaz-Aguilar, Glenn C. Rowe, Jared Iacovelli, Carrie Spencer
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce32a8c4a78c59781e1518a675c08e5
http://europepmc.org/articles/PMC4788093
http://europepmc.org/articles/PMC4788093
Autor:
Yafeng Li, Arvydas Maminishkis, Jared Iacovelli, Joshua L. Dunaief, Oleg Alekseev, Natalie Wolkow, Ying Song, Jennifer C. Lee, Delu Song
Publikováno v:
Experimental Eye Research. 128:92-101
The purpose of our studies was to examine the relationship between iron and melanogenesis in retinal pigment epithelial cells, as prior observations had suggested that iron may promote melanogenesis. This relationship has potential clinical importanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed5ca3ea9a4d353b6864aefc224547b
https://doi.org/10.1016/j.exer.2014.09.010
https://doi.org/10.1016/j.exer.2014.09.010
Publikováno v:
Life Science Alliance. 2:e201800212
The retinal pigment epithelium (RPE) supports visual processing and photoreceptor homeostasis via energetically demanding cellular functions. Here, we describe the consequences of repressing peroxisome proliferator-activated receptor γ coactivator-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfb4bb5796482bc7b9fcb2acf67ee66
https://doi.org/10.26508/lsa.201800212
https://doi.org/10.26508/lsa.201800212
Autor:
Marga Bott, Nizam Uddin, Cristina Fernandez-Valle, Annette R. Khaled, Elizabeth Baldwin, Jared Iacovelli, Jorge Lopera
Publikováno v:
Glia. 55:1638-1647
Proliferation of Schwann cells in vitro, unlike most mammalian cells, is not induced by serum alone but additionally requires cAMP elevation and mitogenic stimulation. How these agents cooperate to promote progression through the G1 phase of the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a711ed62628d38eb7d1ceda8f780e
https://doi.org/10.1002/glia.20578
https://doi.org/10.1002/glia.20578
Autor:
Mina Massaro-Giordano, Robert W. Wong, Xining He, Joshua L. Dunaief, Chih King, Jared Iacovelli, Paul Hahn, Robert B. Bhisitkul
Publikováno v:
Progress in Retinal and Eye Research. 26:649-673
Iron is essential for many metabolic processes but can also cause damage. As a potent generator of hydroxyl radical, the most reactive of the free radicals, iron can cause considerable oxidative stress. Since iron is absorbed through diet but not exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae352ce5057781ec332cba28f7765625
https://doi.org/10.1016/j.preteyeres.2007.07.004
https://doi.org/10.1016/j.preteyeres.2007.07.004